2016
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals
Marchetto M, Belinson H, Tian Y, Freitas B, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo C, Mendes A, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes C, Courchesne E, Geschwind D, Gage F, Wynshaw-Boris A, Muotri A. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Molecular Psychiatry 2016, 22: 820-835. PMID: 27378147, PMCID: PMC5215991, DOI: 10.1038/mp.2016.95.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsInsulin growth factor-1Pluripotent stem cellsTranscriptional cascadeNeuronal networksAutism spectrum disorderGrowth factor-1Human cell modelsNormal brain sizeEarly brain overgrowthPotential cellular mechanismsMolecular mechanismsGenetic studiesClinical trialsIGF-1Therapeutic effectBrain pathologyAbnormal neurogenesisΒ-cateninCellular mechanismsStem cellsBrain overgrowthProgenitor cellsNeural cellsAltered proliferation
2011
Rapid Cellular Turnover in Adipose Tissue
Rigamonti A, Brennand K, Lau F, Cowan C. Rapid Cellular Turnover in Adipose Tissue. PLOS ONE 2011, 6: e17637. PMID: 21407813, PMCID: PMC3047582, DOI: 10.1371/journal.pone.0017637.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipose TissueAnimalsBromodeoxyuridineCell CycleCell ProliferationHumansKi-67 AntigenMiceObesityConceptsCellular turnoverAdipocyte populationsRapid cellular turnoverGreen fluorescent proteinIndependent experimental approachesIncorporation of BrdUFluorescent proteinMurine adipose tissueRapid turnoverTissue turnoverPossible new avenuesTurnoverAdipose tissueExperimental approachNew avenuesHistones
2008
Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics
Szotek P, Chang H, Brennand K, Fujino A, Pieretti-Vanmarcke R, Celso C, Dombkowski D, Preffer F, Cohen K, Teixeira J, Donahoe P. Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 12469-12473. PMID: 18711140, PMCID: PMC2527935, DOI: 10.1073/pnas.0805012105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBromodeoxyuridineCell ProliferationEpithelial CellsEstrous CycleFemaleGreen Fluorescent ProteinsMiceOvaryRegenerationStem CellsConceptsLabel-retaining cell populationStem/progenitor cellsSomatic stem/progenitor cellsEpithelial label-retaining cellsCoelomic epitheliumProgenitor cellsCell populationsCell-mediated processStem/progenitor cell characteristicsLabel-retaining cellsEstrous cyclingAdult miceProgenitor cell characteristicsMouse ovariesCytoprotective mechanismsSide population
2007
All β Cells Contribute Equally to Islet Growth and Maintenance
Brennand K, Huangfu D, Melton D. All β Cells Contribute Equally to Islet Growth and Maintenance. PLOS Biology 2007, 5: e163. PMID: 17535113, PMCID: PMC1877817, DOI: 10.1371/journal.pbio.0050163.Peer-Reviewed Original ResearchMeSH KeywordsAdult Stem CellsAnimalsCell DifferentiationCell ProliferationFemaleGenes, ReporterGenetic MarkersGreen Fluorescent ProteinsHistonesIn Vitro TechniquesInsulin-Secreting CellsIslets of LangerhansMaleMiceMice, Inbred C57BLMice, TransgenicModels, BiologicalMosaicismRecombinant Fusion ProteinsTetracyclineConceptsBeta-cell populationBeta cellsBeta-cell replicationHealthy adult miceBeta-cell poolCell populationsDifferentiated beta cellsStem cellsReplacement therapyCell replacement therapyAdult miceIslet growthΒ-cellsProtein expressionCell poolReplicative capacityCell replicationHepatocyte populationAdult stem cellsClonal analysisCellsLevel of fluorescenceFluorescent protein expressionPopulationDiabetes