Mediation of nonerosive arthritis in a mouse model of lupus by interferon‐α–stimulated monocyte differentiation that is nonpermissive of osteoclastogenesis
Mensah KA, Mathian A, Ma L, Xing L, Ritchlin CT, Schwarz EM. Mediation of nonerosive arthritis in a mouse model of lupus by interferon‐α–stimulated monocyte differentiation that is nonpermissive of osteoclastogenesis. Arthritis & Rheumatism 2010, 62: 1127-1137. PMID: 20131244, PMCID: PMC2854832, DOI: 10.1002/art.27312.Peer-Reviewed Original ResearchConceptsMyeloid dendritic cellsSystemic lupus erythematosusSerum-induced arthritisNZB xBone erosionDendritic cellsOsteoclast precursorsAntibody titersMouse modelAnti-dsDNA antibody titersDNA antibody titersMicrofocal computed tomographyCytokine interferon-alphaEffects of IFNalphaJaccoud's arthritisNonerosive arthritisSLE diseaseJoint inflammationLupus erythematosusAutoimmune diseasesNZW miceSerum administrationInterferon alphaFocal erosionsSLE monocytesCD16 (FcRγIII) as a potential marker of osteoclast precursors in psoriatic arthritis
Chiu YG, Shao T, Feng C, Mensah KA, Thullen M, Schwarz EM, Ritchlin CT. CD16 (FcRγIII) as a potential marker of osteoclast precursors in psoriatic arthritis. Arthritis Research & Therapy 2010, 12: r14. PMID: 20102624, PMCID: PMC2875642, DOI: 10.1186/ar2915.Peer-Reviewed Original ResearchConceptsCD16 expressionOC precursorsInflammatory arthritisHealthy controlsMethodsPeripheral blood mononuclear cellsNuclear factor kappa-B ligandCD16-positive monocytesSubset of CD14Chronic inflammatory arthritisBlood mononuclear cellsHuman peripheral bloodCD16 surface expressionColony-stimulating factorPsA patientsPsoriatic arthritisBone erosionDendritic cellsPsoriasis subjectsMononuclear cellsPeripheral bloodTumor necrosisCD16Receptor activatorBone wafersArthritis