Featured Publications
Inaccuracy of pulse oximetry with dark skin pigmentation: clinical implications and need for improvement
Kyriacou PA, Charlton PH, Al-Halawani R, Shelley KH. Inaccuracy of pulse oximetry with dark skin pigmentation: clinical implications and need for improvement. British Journal Of Anaesthesia 2022, 130: e33-e36. PMID: 35430087, DOI: 10.1016/j.bja.2022.03.011.Peer-Reviewed Original ResearchCOVID-19: Pulse oximeters in the spotlight
Michard F, Shelley K, L’Her E. COVID-19: Pulse oximeters in the spotlight. Journal Of Clinical Monitoring And Computing 2020, 35: 11-14. PMID: 32578070, PMCID: PMC7308445, DOI: 10.1007/s10877-020-00550-7.Peer-Reviewed Original ResearchConceptsPeripheral perfusion indexAcute respiratory failureManagement of patientsIntensive care unitCoronavirus disease 2019Preload-modifying maneuverPulse oximetry waveformRespiratory failureCare unitFluid therapyPreload responsivenessPerfusion indexRespiratory effortDisease 2019Oxygen saturationPulse oximetryHospital wardsPulse oximeterSpO2PatientsTherapyOximetryWards
2023
Improving pulse oximetry accuracy in dark-skinned patients: technical aspects and current regulations
Cabanas A, Martín-Escudero P, Shelley K. Improving pulse oximetry accuracy in dark-skinned patients: technical aspects and current regulations. British Journal Of Anaesthesia 2023, 131: 640-644. PMID: 37544838, DOI: 10.1016/j.bja.2023.07.005.Peer-Reviewed Original ResearchUsing the ear photoplethysmographic waveform as an early indicator of central hypovolemia in healthy volunteers utilizing LBNP induced hypovolemia model
Eid A, Elgamal M, Gonzalez-Fiol A, Shelley K, Wu H, Alian A. Using the ear photoplethysmographic waveform as an early indicator of central hypovolemia in healthy volunteers utilizing LBNP induced hypovolemia model. Physiological Measurement 2023, 44: 055008. PMID: 37116503, DOI: 10.1088/1361-6579/acd165.Peer-Reviewed Original ResearchConceptsLower body negative pressureCentral hypovolemiaHealthy volunteersNon-invasive cardiac output monitorProgressive lower body negative pressureNoninvasive blood pressure monitorBody negative pressureCardiac output monitorBlood pressure monitorPhotoplethysmographic waveformPulse oximetry probeHypoperfusion symptomsSymptomatic subjectsHemodynamic indicesLBNP stageStroke volumeEarly predictorLT groupHypovolemiaEarly stagesPressure monitorWaveform indicesEarly indicatorWaveform morphologySymptoms
2021
Tribute to Dr. Takuo Aoyagi, inventor of pulse oximetry
Miyasaka K, Shelley K, Takahashi S, Kubota H, Ito K, Yoshiya I, Yamanishi A, Cooper JB, Steward DJ, Nishida H, Kiani J, Ogino H, Sata Y, Kopotic RJ, Jenkin K, Hannenberg A, Gawande A. Tribute to Dr. Takuo Aoyagi, inventor of pulse oximetry. Journal Of Anesthesia 2021, 35: 671-709. PMID: 34338865, PMCID: PMC8327306, DOI: 10.1007/s00540-021-02967-z.Peer-Reviewed Original Research
2020
Should We Monitor Pulsus Paradoxus via Pulse Oximetry in Patients with COVID-19 and Acute Respiratory Failure?
Michard F, Shelley K. Should We Monitor Pulsus Paradoxus via Pulse Oximetry in Patients with COVID-19 and Acute Respiratory Failure? American Journal Of Respiratory And Critical Care Medicine 2020, 202: 770-771. PMID: 32492351, PMCID: PMC7462392, DOI: 10.1164/rccm.202004-1504le.Peer-Reviewed Original Research
2016
Ventilation-Induced Modulation of Pulse Oximeter Waveforms
Alian AA, Atteya G, Gaal D, Golembeski T, Smith BG, Dai F, Silverman DG, Shelley K. Ventilation-Induced Modulation of Pulse Oximeter Waveforms. Anesthesia & Analgesia 2016, 123: 346-356. PMID: 27284998, DOI: 10.1213/ane.0000000000001377.Peer-Reviewed Original ResearchConceptsSystolic blood pressureArterial pressure waveformBlood volumeFluid resuscitationBlood pressureOnly systolic blood pressurePressure waveformAirway pressure waveformFinger pulse oximetrySubstantial blood lossDynamic preload indicesVenous blood volumeArterial pressure measurementsArterial waveform parametersP-valuePulse oximeter waveformWilcoxon signed-rank testArterial pressureBlood lossBlood transfusionEarly bleedingPediatric patientsPreload indexHemodynamic dataScoliosis surgery
2014
Photoplethysmography
Alian AA, Shelley KH. Photoplethysmography. Best Practice & Research Clinical Anaesthesiology 2014, 28: 395-406. PMID: 25480769, DOI: 10.1016/j.bpa.2014.08.006.Peer-Reviewed Original Research
2013
Is pulse oximetry an essential tool or just another distraction? The role of the pulse oximeter in modern anesthesia care
Shah A, Shelley KH. Is pulse oximetry an essential tool or just another distraction? The role of the pulse oximeter in modern anesthesia care. Journal Of Clinical Monitoring And Computing 2013, 27: 235-242. PMID: 23314807, DOI: 10.1007/s10877-013-9428-7.Peer-Reviewed Original ResearchConceptsPulse oximetryOutcome studiesAnesthesia carePulse oximeterStandard of careAnesthetic agentsClinical careClinical monitoringPatient careFirst operationCardiovascular monitoringOximetryAvailable evidenceAnesthesiologistsCareOutcomes researchAmerican SocietyFurther studiesPatientsOximeterPatient monitoringRare eventUnambiguous roleNoninvasive cardiovascular monitoringVast majority
2012
Modulation of finger photoplethysmographic traces during forced respiration: Venous blood in motion?
Phillips J, Belhaj A, Shafqat K, Langford R, Shelley K, Kyriacou P. Modulation of finger photoplethysmographic traces during forced respiration: Venous blood in motion? Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2012, 2012: 3644-3647. PMID: 23366717, DOI: 10.1109/embc.2012.6346756.Peer-Reviewed Original ResearchConceptsVenous oxygen saturationOxygen saturationBlood volumeNegative airway pressureAirway pressureVenous bloodArterial saturationRespiratory modulationHealthy volunteersRespiratory frequencyTissue bedsPilot studyResultant modulationArteryModulationFingerBloodPhotoplethysmographic signalsVolunteersRespiratory Physiology and the Impact of Different Modes of Ventilation on the Photoplethysmographic Waveform
Alian AA, Shelley KH. Respiratory Physiology and the Impact of Different Modes of Ventilation on the Photoplethysmographic Waveform. Sensors 2012, 12: 2236-2254. PMID: 22438762, PMCID: PMC3304164, DOI: 10.3390/s120202236.Peer-Reviewed Original Research
2006
What Is the Best Site for Measuring the Effect of Ventilation on the Pulse Oximeter Waveform?
Shelley KH, Jablonka DH, Awad AA, Stout RG, Rezkanna H, Silverman DG. What Is the Best Site for Measuring the Effect of Ventilation on the Pulse Oximeter Waveform? Anesthesia & Analgesia 2006, 103: 372-377. PMID: 16861419, DOI: 10.1213/01.ane.0000222477.67637.17.Peer-Reviewed Original ResearchConceptsPositive pressure ventilationPulse oximeter waveformPressure ventilationPlethysmographic waveformEffect of ventilationBlood lossRenal dialysisSpontaneous breathingPlethysmographic dataSurgical proceduresTidal volumeBlood volumeRespiratory rateVentilationPatientsSignificant correlationRespiratory signalPredominant featureImpact of ventilationCardiac pulseSurgeryFingerBreathingDialysis
2001
How Does the Plethysmogram Derived from the Pulse Oximeter Relate to Arterial Blood Pressure in Coronary Artery Bypass Graft Patients?
Awad A, Ghobashy M, Stout R, Silverman D, Shelley K. How Does the Plethysmogram Derived from the Pulse Oximeter Relate to Arterial Blood Pressure in Coronary Artery Bypass Graft Patients? Anesthesia & Analgesia 2001, 93: 1466-1471. PMID: 11726424, DOI: 10.1097/00000539-200112000-00022.Peer-Reviewed Original ResearchConceptsMean blood pressureSystolic blood pressureBlood pressurePulse pressurePulse oximeter waveformCoronary artery bypass graft surgeryCoronary artery bypass graft patientsArtery bypass graft surgeryBypass graft surgeryCoronary artery bypassBypass graft patientsRadial artery blood pressure waveformArterial blood pressureBlood pressure waveformArtery bypassGraft patientsGraft surgeryArterial linePatientsFinger oximeterMean differenceClinical applicabilityPulse oximeterPressure waveformOximeterDifferent Responses of Ear and Finger Pulse Oximeter Wave Form to Cold Pressor Test
Awad A, Ghobashy M, Ouda W, Stout R, Silverman D, Shelley K. Different Responses of Ear and Finger Pulse Oximeter Wave Form to Cold Pressor Test. Anesthesia & Analgesia 2001, 92: 1483-1486. PMID: 11375830, DOI: 10.1097/00000539-200106000-00026.Peer-Reviewed Original ResearchConceptsCold pressor testVasoconstrictive responsePressor testIce water immersionPlethysmographic amplitudeVasoconstrictive effectSympathetic toneContralateral handHealthy volunteersSystemic circulationIRB approvalCold stimuliClinical settingEarSignificant disparitiesSignificant changesSuitable monitorFingerResponseEar signalsWater immersionPlethysmography
1997
Arterial–Pulse Oximetry Loops: A New Method of Monitoring Vascular Tone
Shelley K, Bosseau Murray W, Chang D. Arterial–Pulse Oximetry Loops: A New Method of Monitoring Vascular Tone. Journal Of Clinical Monitoring 1997, 13: 223-228. PMID: 9269615, DOI: 10.1023/a:1007361020825.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-AgonistsAnesthesia, IntravenousArteriesBlood PressureBlood VolumeCalibrationCephalometryDose-Response Relationship, DrugEphedrineFemaleFingersForecastingHeart RateHumansHypotensionIntraoperative ComplicationsMeningiomaMiddle AgedMonitoring, PhysiologicOnline SystemsOximetryPhenylephrinePlethysmographySignal Processing, Computer-AssistedVascular ResistanceVasoconstrictor AgentsVasomotor SystemConceptsPulse oximeter waveformVascular resistanceVascular toneVascular compliancePeripheral vascular complianceVascular compliance changesPeripheral vascular resistanceDose-response curveArterial pressureCase reportArterial waveformClinical informationCompliance changesRelative complianceComplianceTonePhenylephrineOff-line calculation
1993
The detection of peripheral venous pulsation using the pulse oximeter as a plethysmograph
Shelley K, Dickstein M, Shulman S. The detection of peripheral venous pulsation using the pulse oximeter as a plethysmograph. Journal Of Clinical Monitoring 1993, 9: 283-287. PMID: 8301336, DOI: 10.1007/bf02886699.Peer-Reviewed Original Research