2023
Using the ear photoplethysmographic waveform as an early indicator of central hypovolemia in healthy volunteers utilizing LBNP induced hypovolemia model
Eid A, Elgamal M, Gonzalez-Fiol A, Shelley K, Wu H, Alian A. Using the ear photoplethysmographic waveform as an early indicator of central hypovolemia in healthy volunteers utilizing LBNP induced hypovolemia model. Physiological Measurement 2023, 44: 055008. PMID: 37116503, DOI: 10.1088/1361-6579/acd165.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureHealthy VolunteersHemodynamicsHumansHypovolemiaLower Body Negative PressureOximetryConceptsLower body negative pressureCentral hypovolemiaHealthy volunteersNon-invasive cardiac output monitorProgressive lower body negative pressureNoninvasive blood pressure monitorBody negative pressureCardiac output monitorBlood pressure monitorPhotoplethysmographic waveformPulse oximetry probeHypoperfusion symptomsSymptomatic subjectsHemodynamic indicesLBNP stageStroke volumeEarly predictorLT groupHypovolemiaEarly stagesPressure monitorWaveform indicesEarly indicatorWaveform morphologySymptoms
2018
Using support vector machines on photoplethysmographic signals to discriminate between hypovolemia and euvolemia
Reljin N, Zimmer G, Malyuta Y, Shelley K, Mendelson Y, Blehar DJ, Darling CE, Chon KH. Using support vector machines on photoplethysmographic signals to discriminate between hypovolemia and euvolemia. PLOS ONE 2018, 13: e0195087. PMID: 29596477, PMCID: PMC5875841, DOI: 10.1371/journal.pone.0195087.Peer-Reviewed Original ResearchConceptsBlood lossTrauma patientsTraditional vital signsLast time pointBlood pressureHemorrhagic shockCombat casualty careBlood withdrawalHealthy volunteersPhotoplethysmographic recordingsHeart rateBlood volumeEuvolemiaVital signsHypovolemiaPercentage changeTime pointsAbsolute changeCasualty carePatientsBattlefield settingsEarly stagesHemorrhageRecordingsHospital
2016
Ventilation-Induced Modulation of Pulse Oximeter Waveforms
Alian AA, Atteya G, Gaal D, Golembeski T, Smith BG, Dai F, Silverman DG, Shelley K. Ventilation-Induced Modulation of Pulse Oximeter Waveforms. Anesthesia & Analgesia 2016, 123: 346-356. PMID: 27284998, DOI: 10.1213/ane.0000000000001377.Peer-Reviewed Original ResearchConceptsSystolic blood pressureArterial pressure waveformBlood volumeFluid resuscitationBlood pressureOnly systolic blood pressurePressure waveformAirway pressure waveformFinger pulse oximetrySubstantial blood lossDynamic preload indicesVenous blood volumeArterial pressure measurementsArterial waveform parametersP-valuePulse oximeter waveformWilcoxon signed-rank testArterial pressureBlood lossBlood transfusionEarly bleedingPediatric patientsPreload indexHemodynamic dataScoliosis surgery
2014
Photoplethysmography
Alian AA, Shelley KH. Photoplethysmography. Best Practice & Research Clinical Anaesthesiology 2014, 28: 395-406. PMID: 25480769, DOI: 10.1016/j.bpa.2014.08.006.Peer-Reviewed Original ResearchImpact of lower body negative pressure induced hypovolemia on peripheral venous pressure waveform parameters in healthy volunteers
Alian AA, Galante NJ, Stachenfeld NS, Silverman DG, Shelley KH. Impact of lower body negative pressure induced hypovolemia on peripheral venous pressure waveform parameters in healthy volunteers. Physiological Measurement 2014, 35: 1509-1520. PMID: 24901895, DOI: 10.1088/0967-3334/35/7/1509.Peer-Reviewed Original ResearchConceptsLower body negative pressureBlood pressureBody negative pressureCardiac modulationHeart ratePulse pressurePVP waveformsProgressive lower body negative pressureArterial systolic blood pressureFinger arterial blood pressurePeripheral venous pressure waveformsMmHg lower body negative pressureMean blood pressureDiastolic blood pressureSystolic blood pressureArterial blood pressureArterial BP valuesPressure waveformSignificant reductionMild hypovolemiaVenous pressureHemodynamic changesIntravenous siteRespiratory modulationBP values
2012
Using Time-Frequency Analysis of the Photoplethysmographic Waveform to Detect the Withdrawal of 900 mL of Blood
Scully CG, Selvaraj N, Romberg FW, Wardhan R, Ryan J, Florian JP, Silverman DG, Shelley KH, Chon KH. Using Time-Frequency Analysis of the Photoplethysmographic Waveform to Detect the Withdrawal of 900 mL of Blood. Anesthesia & Analgesia 2012, 115: 74-81. PMID: 22543068, DOI: 10.1213/ane.0b013e318256486c.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureBlood Pressure DeterminationBlood Transfusion, AutologousBlood VolumeBlood Volume DeterminationCluster AnalysisConnecticutElectrocardiographyHeart RateHumansHypovolemiaInfrared RaysMalePhotoplethysmographyPredictive Value of TestsRespiratory MechanicsSensitivity and SpecificitySignal Processing, Computer-AssistedTime FactorsConceptsML of bloodArterial blood pressureBlood lossBlood pressureHeart rateHeart rate frequencyBlood withdrawalML blood lossMean percent decreaseBlood volume lossHeart rate componentSignificant changesPhotoplethysmographic waveformSpontaneous breathingTrauma settingCuff measurementsPPG waveformBlood reinfusionHealthy volunteersStandard electrocardiogramBloodEarly detectionEar PPG signalsBaselineConfidence intervals