2020
Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep.
Zeng C, Motta-Ribeiro G, Hinoshita T, Lessa M, Winkler T, Grogg K, Kingston N, Hutchinson J, Sholl L, Fang X, Varelas X, Layne M, Baron R, Vidal Melo M. Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep. Anesthesiology 2020, 133: 1060-1076. PMID: 32796202, PMCID: PMC7572680, DOI: 10.1097/aln.0000000000003491.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleImmunity, CellularLung Volume MeasurementsPulmonary AtelectasisSheepTranscriptomeConceptsAlveolar-capillary barrier functionInterferon-stimulated genesImmune responseLung atelectasisAerated lungBarrier functionAerated lung regionsPulmonary transcriptomeSystemic lipopolysaccharideYes-associated protein signalingPulmonary atelectasisGene set enrichment analysisSystemic inflammationBronchial blockerLung injuryRight lungBarrier dysfunctionComputed tomographyLipopolysaccharide exposureAtelectasisLipopolysaccharide infusionAbsolute fold changeYes-associated proteinAtelectatic lungLung
2018
Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury
Motta-Ribeiro G, Hashimoto S, Winkler T, Baron R, Grogg K, Paula L, Santos A, Zeng C, Hibbert K, Harris R, Bajwa E, Vidal Melo M. Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury. American Journal Of Respiratory And Critical Care Medicine 2018, 198: 891-902. PMID: 29787304, PMCID: PMC6173064, DOI: 10.1164/rccm.201710-2038oc.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAnalysis of VarianceAnimalsBiopsy, NeedleBlood Gas AnalysisDisease Models, AnimalEndotoxemiaEndotoxinsFemaleFluorodeoxyglucose F18HumansImmunohistochemistryInfusions, IntravenousLinear ModelsMultivariate AnalysisPositron-Emission TomographyPulmonary AtelectasisRandom AllocationRespiration, ArtificialRespiratory Distress SyndromeRespiratory Function TestsRisk FactorsSheepTidal VolumeTime FactorsTomography, X-Ray ComputedConceptsLung injurySupine lungConsistent with clinical practiceBlood volumeF-FDG phosphorylation rateLocal neutrophilic inflammationAssociated with increased inflammationF-FDG uptakeEarly mechanical ventilationClinical practiceEarly lung injuryPositive end-expiratory pressureLung strainEnd-expiratory pressurePositron emission tomographyF-FDGUninjured lungsImaging findingsRegional inflammationNeutrophilic inflammationSystemic endotoxemiaProne positionComputed tomographyVentilated patientsIntravenous endotoxin