2024
Mechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model
Lagier D, Zeng C, Kaczka D, Zhu M, Grogg K, Gerard S, Reinhardt J, Ribeiro G, Rashid A, Winkler T, Vidal Melo M. Mechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model. Science Translational Medicine 2024, 16: eado1097. PMID: 39141699, DOI: 10.1126/scitranslmed.ado1097.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureMechanical ventilationFour-dimensional computed tomographyParenchymal strainsVentilator-induced lung injuryAcute respiratory distress syndromeRespiratory system driving pressureManagement of mechanical ventilationPositive end-expiratory pressure valuesRespiratory distress syndromeTidal overdistensionEnd-expiratory pressureAssociated with mortalityPulmonary complicationsLung biomechanicsLung massDistress syndromeClinical outcomesLung injuryComputed tomographyClinical managementGeneral anesthesiaLung collapseDriving pressureLung
2020
Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep.
Zeng C, Motta-Ribeiro G, Hinoshita T, Lessa M, Winkler T, Grogg K, Kingston N, Hutchinson J, Sholl L, Fang X, Varelas X, Layne M, Baron R, Vidal Melo M. Lung Atelectasis Promotes Immune and Barrier Dysfunction as Revealed by Transcriptome Sequencing in Female Sheep. Anesthesiology 2020, 133: 1060-1076. PMID: 32796202, PMCID: PMC7572680, DOI: 10.1097/aln.0000000000003491.Peer-Reviewed Original ResearchConceptsAlveolar-capillary barrier functionInterferon-stimulated genesImmune responseLung atelectasisAerated lungBarrier functionAerated lung regionsPulmonary transcriptomeSystemic lipopolysaccharideYes-associated protein signalingPulmonary atelectasisGene set enrichment analysisSystemic inflammationBronchial blockerLung injuryRight lungBarrier dysfunctionComputed tomographyLipopolysaccharide exposureAtelectasisLipopolysaccharide infusionAbsolute fold changeYes-associated proteinAtelectatic lungLung