2005
Influence of Psychiatric Comorbidity on Recovery and Recurrence in Generalized Anxiety Disorder, Social Phobia, and Panic Disorder: A 12-Year Prospective Study
Bruce SE, Yonkers KA, Otto MW, Eisen JL, Weisberg RB, Pagano M, Shea MT, Keller MB. Influence of Psychiatric Comorbidity on Recovery and Recurrence in Generalized Anxiety Disorder, Social Phobia, and Panic Disorder: A 12-Year Prospective Study. American Journal Of Psychiatry 2005, 162: 1179-1187. PMID: 15930067, PMCID: PMC3272761, DOI: 10.1176/appi.ajp.162.6.1179.Peer-Reviewed Original ResearchConceptsComorbid psychiatric disordersClinical courseAnxiety disordersPanic disorderPsychiatric disordersHarvard/Brown Anxiety Disorders Research ProgramLong-term clinical courseProportional hazards regression analysisOverall clinical courseChronic clinical courseHazards regression analysisSocial phobiaComorbid psychiatric conditionsStandard survival analysis methodsGeneralized anxiety disorderLikelihood of recoveryChronic courseProspective studyMulticenter studyPsychiatric comorbidityRisk ratioMajor depressionRecurrencePsychiatric predictorsSurvival analysis
2003
Chronicity, relapse, and illness—course of panic disorder, social phobia, and generalized anxiety disorder: Findings in men and women from 8 years of follow‐up
Yonkers KA, Bruce SE, Dyck IR, Keller MB. Chronicity, relapse, and illness—course of panic disorder, social phobia, and generalized anxiety disorder: Findings in men and women from 8 years of follow‐up. Depression And Anxiety 2003, 17: 173-179. PMID: 12768651, DOI: 10.1002/da.10106.Peer-Reviewed Original ResearchConceptsHarvard/Brown Anxiety Research ProgramClinical courseRelapse rateUncomplicated panic disorderPanic disorderAnxiety disordersRelapse eventsSex differencesSocial phobiaCumulative remission rateMajority of menFrequent remissionsRemission ratePrognostic implicationsChronic illnessRelapse statusRemissionYears of observationPatientsEnduring illnessSame cohortSignificant sex differencesMonth intervalsIllnessObservation period
2001
An Eight-Year Longitudinal Comparison of Clinical Course and Characteristics of Social Phobia Among Men and Women
Yonkers KA, Dyck IR, Keller MB. An Eight-Year Longitudinal Comparison of Clinical Course and Characteristics of Social Phobia Among Men and Women. Psychiatric Services 2001, 52: 637-643. PMID: 11331798, DOI: 10.1176/appi.ps.52.5.637.Peer-Reviewed Original ResearchConceptsHealth-related qualityHarvard/Brown Anxiety Research ProgramSuicide attemptsSocial phobiaComorbid substance use disorderPoorer baseline functioningLower Global AssessmentPercent of menPercent of womenSubstance use disordersPotential sex differencesComplete remissionRemission rateClinical courseChronic courseEight-year study periodChronic disordersHigh prevalenceObservational studyFunctioning scoresUse disordersBaseline functioningConcurrent agoraphobiaGreater chronicityGlobal assessment