2022
Association of depression and anxiety disorders with outcomes after revascularization in chronic limb-threatening ischemia hospitalizations nationwide
Harris KM, Mena-Hurtado C, Burg MM, Vriens PW, Heyligers J, Smolderen KG. Association of depression and anxiety disorders with outcomes after revascularization in chronic limb-threatening ischemia hospitalizations nationwide. Journal Of Vascular Surgery 2022, 77: 480-489. PMID: 36115521, DOI: 10.1016/j.jvs.2022.09.008.Peer-Reviewed Original ResearchConceptsLength of stayChronic limb-threatening ischemiaAnxiety disorder diagnosisAssociation of depressionRevascularization cohortMajor amputationDisorder diagnosisSurgical revascularizationEndovascular revascularizationHigher oddsLonger median LOSMedian LOSLonger LOSAnxiety disordersDocumentation of depressionPeripheral artery diseaseLimb-threatening ischemiaRisk of amputationNational Inpatient SamplePatients' sociodemographic dataHigher median costArtery diseaseIllness severityPsychiatric comorbidityComorbid depression
2021
Increasing Prevalence of Critical Limb Ischemia Hospitalizations With Distinct Mental Health Burden Among Younger Adults
Harris KM, Mena-Hurtado C, Arham A, Burg MM, Freedland KE, Sinha R, Alabi O, Smolderen KG. Increasing Prevalence of Critical Limb Ischemia Hospitalizations With Distinct Mental Health Burden Among Younger Adults. Journal Of The American College Of Cardiology 2021, 78: 2126-2128. PMID: 34794693, DOI: 10.1016/j.jacc.2021.09.025.Peer-Reviewed Original ResearchContemporary Trends in Hospital Admissions and Outcomes in Patients With Critical Limb Ischemia
Anantha-Narayanan M, Doshi RP, Patel K, Sheikh AB, Llanos-Chea F, Abbott JD, Shishehbor MH, Guzman RJ, Hiatt WR, Duval S, Mena-Hurtado C, Smolderen KG. Contemporary Trends in Hospital Admissions and Outcomes in Patients With Critical Limb Ischemia. Circulation Cardiovascular Quality And Outcomes 2021, 14: e007539. PMID: 33541110, DOI: 10.1161/circoutcomes.120.007539.Peer-Reviewed Original ResearchConceptsLength of stayMajor amputationCost of hospitalizationHospital mortalitySurgical interventionEndovascular interventionBlack raceHigh-risk patient profileNational Inpatient Sample dataHigher major amputationMore endovascular interventionsRisk patient profileCritical limb ischemiaOpen surgical interventionMultivariable regression analysisHierarchical multivariable regression analysisCLI cohortHospital admissionLimb ischemiaPrimary outcomeRevascularization proceduresSecondary outcomesAtherosclerotic diseaseMale sexFemale sex
2015
Risk Factors for Rehospitalization for Acute Coronary Syndromes and Unplanned Revascularization Following Acute Myocardial Infarction
Arnold SV, Smolderen KG, Kennedy KF, Li Y, Shore S, Stolker JM, Wang TY, Jones PG, Zhao Z, Spertus JA. Risk Factors for Rehospitalization for Acute Coronary Syndromes and Unplanned Revascularization Following Acute Myocardial Infarction. Journal Of The American Heart Association 2015, 4: e001352. PMID: 25666368, PMCID: PMC4345868, DOI: 10.1161/jaha.114.001352.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeAcute myocardial infarctionCoronary syndromeMyocardial infarctionRisk factorsHospital percutaneous coronary interventionCoronary artery bypass graftSecondary prevention therapiesArtery bypass graftRisk of rehospitalizationMortality risk scorePercutaneous coronary interventionPredictors of rehospitalizationRate of rehospitalizationBare metal stentsStrongest predictorMultivessel diseaseUnplanned revascularizationCause readmissionCoronary revascularizationCoronary interventionSubsequent revascularizationPrevention therapyRevascularization proceduresAMI registry
2011
Two-year Vascular Hospitalisation Rates and Associated Costs in Patients at Risk of Atherothrombosis in France and Germany: Highest Burden for Peripheral Arterial Disease
Smolderen KG, Wang K, de Pouvourville G, Brüggenjürgen B, Röther J, Zeymer U, Parhofer KG, Steg PG, Bhatt DL, Magnuson EA, Investigators R. Two-year Vascular Hospitalisation Rates and Associated Costs in Patients at Risk of Atherothrombosis in France and Germany: Highest Burden for Peripheral Arterial Disease. European Journal Of Vascular And Endovascular Surgery 2011, 43: 198-207. PMID: 22001145, DOI: 10.1016/j.ejvs.2011.09.016.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseCoronary artery diseaseHospitalisation ratesCerebrovascular diseaseArterial diseaseMultiple risk factorsRisk of atherothrombosisMRF groupPAD subgroupsREACH RegistryCardiovascular eventsPeripheral revascularizationArtery diseaseHospitalisation costsAtherothrombotic diseasePeripheral proceduresRisk factorsRisk groupsHigh burdenEconomic burdenPatientsDiseaseAtherothrombosisEvaluated groupAssociated costs
2010
Vascular Hospitalization Rates and Costs in Patients With Peripheral Artery Disease in the United States
Mahoney EM, Wang K, Keo HH, Duval S, Smolderen KG, Cohen DJ, Steg G, Bhatt DL, Hirsch AT. Vascular Hospitalization Rates and Costs in Patients With Peripheral Artery Disease in the United States. Circulation Cardiovascular Quality And Outcomes 2010, 3: 642-651. PMID: 20940249, DOI: 10.1161/circoutcomes.109.930735.Peer-Reviewed Original ResearchConceptsAsymptomatic peripheral artery diseasePeripheral artery diseaseAnkle-brachial indexArtery diseaseSymptomatic peripheral artery diseaseAtherothrombotic risk factorsContinued Health (REACH) RegistryCumulative hospitalization costsHistory of claudicationLimb ischemic eventsLower limb revascularizationReduction of AtherothrombosisInternational prospective registryAbsence of symptomsRisk of atherothrombosisLower limb amputationREACH cohortIntermittent claudicationProspective registryIschemic eventsPeripheral interventionsRevascularization proceduresArterial diseaseFirst admissionUS patientsOne-year costs associated with cardiovascular disease in Canada: Insights from the REduction of Atherothrombosis for Continued Health (REACH) registry
Smolderen KG, Bell A, Lei Y, Cohen EA, Steg PG, Bhatt DL, Mahoney EM, investigators O. One-year costs associated with cardiovascular disease in Canada: Insights from the REduction of Atherothrombosis for Continued Health (REACH) registry. Canadian Journal Of Cardiology 2010, 26: e297-e305. PMID: 20931098, PMCID: PMC2954538, DOI: 10.1016/s0828-282x(10)70437-2.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseContinued Health (REACH) RegistryReduction of AtherothrombosisCardiovascular risk factorsCoronary artery diseaseArterial bedMedication useHospitalization costsAtherothrombotic diseaseArtery diseaseMedication costsCerebrovascular diseaseHealth registriesRisk factorsEconomic burdenMore cardiovascular risk factorsAnnual hospitalization costsCardiovascular-related hospitalizationsMean hospitalization costOne-year followOne-year costsCardiovascular eventsPolyvascular diseaseAnnual hospitalizationsClinical factors
2009
The Association of Cognitive and Somatic Depressive Symptoms With Depression Recognition and Outcomes After Myocardial Infarction
Smolderen KG, Spertus JA, Reid KJ, Buchanan DM, Krumholz HM, Denollet J, Vaccarino V, Chan PS. The Association of Cognitive and Somatic Depressive Symptoms With Depression Recognition and Outcomes After Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2009, 2: 328-337. PMID: 20031858, PMCID: PMC2779543, DOI: 10.1161/circoutcomes.109.868588.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCognitive depressive symptomsSomatic depressive symptomsDepressive symptomsSomatic symptomsAMI patientsMyocardial infarctionCognitive symptomsUnadjusted Cox regression analysisPatient Health Questionnaire scoresDepression recognitionLong-term prognosisCox regression analysisLong-term outcomesRecognition of depressionAssociation of CognitiveCause mortalityCause rehospitalizationIndex hospitalizationMultivariable adjustmentAMI registrySymptom scoresClinical recognitionIndependent associationMedical records