2021
Variability in utilization of diagnostic imaging tests in patients with symptomatic peripheral artery disease
Derbas LA, Patel KK, Muskula PR, Wang J, Gosch K, Fitridge R, Spertus JA, Smolderen KG. Variability in utilization of diagnostic imaging tests in patients with symptomatic peripheral artery disease. International Journal Of Cardiology 2021, 330: 200-206. PMID: 33581177, DOI: 10.1016/j.ijcard.2021.02.014.Peer-Reviewed Original ResearchMeSH KeywordsDiagnostic ImagingHumansLogistic ModelsOdds RatioPeripheral Arterial DiseaseReferral and ConsultationConceptsPeripheral arterial diseaseMedian odds ratioImaging testsSymptomatic peripheral artery diseaseSymptomatic peripheral arterial diseaseInvasive imaging testsPAQ summary scoreVascular specialty clinicsPatient-level factorsPeripheral artery diseaseDiagnostic imaging testsHierarchical logistic regression modelsLogistic regression modelsMean ABIPAD diagnosisNew onsetPAD symptomsPatient demographicsArtery diseasePatient characteristicsVascular clinicArterial diseaseDisease characteristicsRecent exacerbationReferral rates
2014
Peripheral arterial disease, gender, and depression in the Heart and Soul Study
Grenon SM, Cohen BE, Smolderen K, Vittinghoff E, Whooley MA, Hiramoto J. Peripheral arterial disease, gender, and depression in the Heart and Soul Study. Journal Of Vascular Surgery 2014, 60: 396-403. PMID: 24661811, PMCID: PMC4199228, DOI: 10.1016/j.jvs.2014.02.013.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseRisk factorsArterial diseaseDevelopment of PADStable coronary artery diseaseGender-specific risk factorsNontraditional risk factorsProspective cohort studyWorse lipid profileHistory of smokingTraditional risk factorsCoronary artery diseaseStrongest independent factorRole of depressionLogistic regression modelsSoul StudyCohort studyInflammatory biomarkersArtery diseaseDiabetes mellitusElevated fibrinogenSimilar prevalenceLipid profileHigh prevalenceIndependent factorsDeterminants of invasive treatment in lower extremity peripheral arterial disease
van Zitteren M, Vriens PW, Burger DH, de Fijter WM, Gerritsen GP, Heyligers JM, Nooren MJ, Smolderen KG. Determinants of invasive treatment in lower extremity peripheral arterial disease. Journal Of Vascular Surgery 2014, 59: 400-408.e2. PMID: 24461863, DOI: 10.1016/j.jvs.2013.08.045.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnkle Brachial IndexChi-Square DistributionDecision Support TechniquesEndovascular ProceduresFemaleHealth StatusHumansLower ExtremityMaleMiddle AgedNetherlandsOdds RatioPatient SelectionPeripheral Arterial DiseasePredictive Value of TestsProspective StudiesReferral and ConsultationRisk FactorsTreatment OutcomeUltrasonography, Doppler, DuplexVascular Surgical ProceduresConceptsPeripheral arterial diseaseLower extremity peripheral arterial diseasePhysical component scaleInvasive treatmentLesion locationHealth statusArterial diseaseTreatment referralSymptomatic lower extremity peripheral arterial diseaseProspective observational cohort studyVascular surgery outpatient clinicProximal lesion locationAnkle-brachial indexObservational cohort studySurgery outpatient clinicShort Form-12Poor health statusPatients' health statusPoisson regression analysisPAD diagnosisCohort studyPAD symptomsIndependent predictorsAmbulatory patientsForm-12
2013
Preoperative Anxiety as a Predictor of Mortality and Major Morbidity in Patients Aged >70 Years Undergoing Cardiac Surgery
Williams JB, Alexander KP, Morin JF, Langlois Y, Noiseux N, Perrault LP, Smolderen K, Arnold SV, Eisenberg MJ, Pilote L, Monette J, Bergman H, Smith PK, Afilalo J. Preoperative Anxiety as a Predictor of Mortality and Major Morbidity in Patients Aged >70 Years Undergoing Cardiac Surgery. The American Journal Of Cardiology 2013, 111: 137-142. PMID: 23245838, PMCID: PMC3677723, DOI: 10.1016/j.amjcard.2012.08.060.Peer-Reviewed Original ResearchConceptsMajor morbidityCardiac surgeryHigh preoperative anxietyPreoperative anxietyHospital AnxietyDepression ScaleThoracic surgeonsProspective multicenter cohort studyMultivariable logistic regression analysisPatient-reported anxietyMulticenter cohort studyPredictors of mortalityTertiary care hospitalType of surgeryMain outcome measuresRisk of mortalityDepression Scale scoresPrimary predictor variableLogistic regression analysisPatients AgedPostoperative mortalityCause mortalityFrailty assessmentIndex hospitalizationCohort study
2012
Self-reported symptoms on questionnaires and anatomic lesions on duplex ultrasound examinations in patients with peripheral arterial disease
van Zitteren M, Vriens PW, Heyligers JM, Burger DH, Nooren MJ, de Fijter WM, Denollet J, Smolderen KG. Self-reported symptoms on questionnaires and anatomic lesions on duplex ultrasound examinations in patients with peripheral arterial disease. Journal Of Vascular Surgery 2012, 55: 1025-1034.e2. PMID: 22244858, DOI: 10.1016/j.jvs.2011.10.115.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsCross-Sectional StudiesFemaleFollow-Up StudiesHumansIntermittent ClaudicationLogistic ModelsLower ExtremityMaleMultivariate AnalysisOdds RatioPain MeasurementPeripheral Arterial DiseaseRisk FactorsSelf ReportSeverity of Illness IndexSurveys and QuestionnairesUltrasonography, Doppler, DuplexConceptsPeripheral arterial diseaseCardiovascular risk factorsDuplex ultrasound examinationDistal lesionsProximal lesionsLesion locationLeg symptomsPatient characteristicsSelf-reported symptomsArterial diseaseRisk factorsUltrasound examinationLower extremity peripheral arterial diseaseVascular surgery outpatient clinicMultivariable logistic regression analysisExertional leg symptomsNew-onset symptomsCardiovascular risk profileSurgery outpatient clinicMain outcome measuresCross-sectional studyFurther diagnostic imagingLogistic regression analysisTailor-made managementPAD subgroups
2010
Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms
Smolderen KG, Spertus JA, Vriens PW, Kranendonk S, Nooren M, Denollet J. Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms. Journal Of Vascular Surgery 2010, 52: 637-644. PMID: 20576397, DOI: 10.1016/j.jvs.2010.04.025.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAnkle Brachial IndexDepressionFemaleHealth Status DisparitiesHumansIncidenceLogistic ModelsMaleMiddle AgedNetherlandsOdds RatioPeripheral Vascular DiseasesProspective StudiesPsychiatric Status Rating ScalesRegistriesRisk AssessmentRisk FactorsSex FactorsTime FactorsConceptsPeripheral arterial diseaseSignificant depressive symptomsDepressive symptomsGender-age groupsYoung womenArterial diseaseSymptomatic peripheral arterial diseaseEpidemiological Studies Depression ScaleFourfold greater oddsVascular outpatient clinicAnkle-brachial indexPatients' depressive symptomsTime of diagnosisLogistic regression modelsImportant comorbidityPAD diagnosisPAD patientsClinical factorsDepression screeningOutpatient clinicCardiovascular diseaseDepression riskDepression ScaleAdditional adjustmentGreater odds
2009
Impact of peripheral arterial disease on health status: A comparison with chronic heart failure
Smolderen KG, Pelle AJ, Kupper N, Mols F, Denollet J. Impact of peripheral arterial disease on health status: A comparison with chronic heart failure. Journal Of Vascular Surgery 2009, 50: 1391-1398. PMID: 19958988, DOI: 10.1016/j.jvs.2009.07.109.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAmbulatory Care FacilitiesChronic DiseaseCost of IllnessCross-Sectional StudiesEducational StatusFemaleHeart DiseasesHeart FailureHumansLogistic ModelsMaleMarital StatusMental HealthMiddle AgedNetherlandsOdds RatioPeripheral Vascular DiseasesPropensity ScoreRisk AssessmentRisk FactorsSickness Impact ProfileConceptsPeripheral arterial diseaseChronic heart failurePhysical health statusMental health statusCHF patientsHealth statusPAD patientsCardiac historyDiabetes mellitusHeart failureArterial diseaseMedical recordsMedical conditionsImpact of PADLow ankle-brachial indexPatients' physical health statusYounger ageWorse physical health statusCross-sectional observational studyMental health status scoresComorbid diabetes mellitusAnkle-brachial indexClinical risk factorsHealth status scoresShort Form-12Lower-leg symptoms in peripheral arterial disease are associated with anxiety, depression, and anhedonia
Smolderen KG, Hoeks SE, Pedersen SS, van Domburg RT, de Liefde II, Poldermans D. Lower-leg symptoms in peripheral arterial disease are associated with anxiety, depression, and anhedonia. Vascular Medicine 2009, 14: 297-304. PMID: 19808714, DOI: 10.1177/1358863x09104658.Peer-Reviewed Original ResearchConceptsAtypical leg symptomsPeripheral arterial diseaseExertional leg symptomsAnkle-brachial indexLeg symptomsIntermittent claudicationDepressive symptomsPAD patientsClinical factorsArterial diseaseAnkle-brachial index screeningSan Diego Claudication QuestionnaireClassic intermittent claudicationConsecutive PAD patientsLower leg symptomsDiverse clinical manifestationsErasmus Medical CenterMood statesSub-threshold symptomsCardiovascular historyMedication useTwofold riskClinical manifestationsPoor prognosisHospital AnxietyPreoperative Cardiac Risk Index Predicts Long-term Mortality and Health Status
Hoeks SE, Reimer W, van Gestel YR, Smolderen KG, Verhagen H, van Domburg RT, van Urk H, Poldermans D. Preoperative Cardiac Risk Index Predicts Long-term Mortality and Health Status. The American Journal Of Medicine 2009, 122: 559-565. PMID: 19376487, DOI: 10.1016/j.amjmed.2008.10.041.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiovascular DiseasesCerebrovascular DisordersConfidence IntervalsData CollectionDiabetes Mellitus, Type 1FemaleFollow-Up StudiesHealth StatusHealth SurveysHumansMaleMiddle AgedNetherlandsOdds RatioPerioperative CarePeripheral Vascular DiseasesPredictive Value of TestsPreoperative CarePrognosisRegression AnalysisRenal InsufficiencyRisk AdjustmentRisk AssessmentRisk FactorsSurveys and QuestionnairesSurvival AnalysisVascular Surgical ProceduresConceptsPeripheral Artery QuestionnaireImpaired health statusPeripheral arterial disease patientsArterial disease patientsInsulin-dependent diabetesLate mortalityPrognostic factorsHealth statusVascular surgeryRenal insufficiencyCerebrovascular diseaseDisease patientsDisease-specific Peripheral Artery QuestionnaireLong-term health statusPAQ summary scorePerioperative cardiac riskCardiac risk factorsCardiac Risk IndexLong-term mortalityPeripheral arterial diseaseImportant prognostic factorIndependent prognostic factorIschemic heart diseaseMultivariable regression analysisRisk index score