2022
A Narrative Review of the Association Between Depression and Heart Disease Among Women: Prevalence, Mechanisms of Action, and Treatment
Rome D, Sales A, Leeds R, Usseglio J, Cornelius T, Monk C, Smolderen KG, Moise N. A Narrative Review of the Association Between Depression and Heart Disease Among Women: Prevalence, Mechanisms of Action, and Treatment. Current Atherosclerosis Reports 2022, 24: 709-720. PMID: 35751731, PMCID: PMC9398966, DOI: 10.1007/s11883-022-01048-0.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesCoronary DiseaseDepressionFemaleHumansMalePrevalenceRisk FactorsSex FactorsConceptsCoronary heart diseaseCardiovascular diseaseMechanism of actionHeart diseaseNarrative reviewManagement of depressionPrevalence of depressionRecent FindingsWomenCardiovascular outcomesAutonomic factorsDepression treatmentComorbid depressionTreatment inertiaGreater prevalenceTherapeutic targetPrevalenceStrong associationWomenDepressionDiseaseGreater mortalityTreatment effectsAssociationMenTreatment
2020
Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences
Jelani Q, Mena‐Hurtado C, Burg M, Soufer R, Gosch K, Jones PG, Spertus JA, Safdar B, Smolderen KG. Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences. Journal Of The American Heart Association 2020, 9: e014583. PMID: 32781883, PMCID: PMC7660812, DOI: 10.1161/jaha.119.014583.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseDepressive symptomsHealth statusArtery diseaseEQ-5D visual analog scale scoresEQ-5D visual analog scaleVisual analog scale scoreGeneric health statusPeripheral Artery QuestionnaireVascular specialty clinicsAnalog scale scoreHealth status scoresPatient Health QuestionnaireSevere depressive symptomsVisual analog scaleHealth status outcomesWorse health statusAdjusted general linear modelSex differencesPORTRAIT registryPAD diagnosisPAD symptomsAnalog scaleConclusions WomenMean age
2019
Psychosocial Factors and Recovery After Acute Myocardial Infarction in Younger Women
Smolderen KG, Brush A, Dreyer RP. Psychosocial Factors and Recovery After Acute Myocardial Infarction in Younger Women. Current Cardiology Reports 2019, 21: 50. PMID: 31020453, DOI: 10.1007/s11886-019-1140-x.Peer-Reviewed Original ResearchConceptsYoung womenAMI outcomesAMI carePsychosocial factorsPsychosocial stressorsAcute myocardial infarction riskAcute myocardial infarctionMyocardial infarction riskPurpose of ReviewToPotential psychosocial factorsAMI riskMyocardial infarctionCare pathwayOutpatient careWorse outcomesAMI incidenceInfarction riskEquitable careMortality ratePsychosocial interventionsCareWomenOutcomesRiskIncidence
2018
Association between health status and sociodemographic, clinical and treatment disparities in the Patient-centered Outcomes Related to TReatment Practices in Peripheral Arterial Disease: Investigating Trajectories (PORTRAIT) registry
Noyes AM, Abbott JD, Gosch K, Smolderen K, Spertus JA, Hyder O, Soukas P, Shishehbor MH, Aronow HD. Association between health status and sociodemographic, clinical and treatment disparities in the Patient-centered Outcomes Related to TReatment Practices in Peripheral Arterial Disease: Investigating Trajectories (PORTRAIT) registry. Vascular Medicine 2018, 23: 32-38. PMID: 29338591, DOI: 10.1177/1358863x17747047.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePoor health statusIntermittent claudicationHealth statusPatient characteristicsDisease-specific health status measuresNon-vascular factorsPeripheral arterial diseaseChronic lung diseaseSpecialty care visitsTime of presentationHealth status measuresMultivariable linear regressionPatients' health statusQuality of lifeCare visitsArtery diseaseInitial presentationArterial diseaseBack painExercise programTreatment disparitiesLung diseaseFemale sexFunctional status
2017
Depression Treatment and Health Status Outcomes in Young Patients With Acute Myocardial Infarction
Smolderen KG, Spertus JA, Gosch K, Dreyer RP, D'Onofrio G, Lichtman JH, Geda M, Beltrame J, Safdar B, Bueno H, Krumholz HM. Depression Treatment and Health Status Outcomes in Young Patients With Acute Myocardial Infarction. Circulation 2017, 135: 1762-1764. PMID: 28461419, PMCID: PMC5755692, DOI: 10.1161/circulationaha.116.027042.Peer-Reviewed Original ResearchSex differences in disease-specific health status measures in patients with symptomatic peripheral artery disease: Data from the PORTRAIT study
Roumia M, Aronow HD, Soukas P, Gosch K, Smolderen KG, Spertus JA, Abbott JD. Sex differences in disease-specific health status measures in patients with symptomatic peripheral artery disease: Data from the PORTRAIT study. Vascular Medicine 2017, 22: 103-109. PMID: 28429659, DOI: 10.1177/1358863x16686408.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnkle Brachial IndexAustraliaChi-Square DistributionCost of IllnessFemaleHealth Status DisparitiesHealth Status IndicatorsHumansIntermittent ClaudicationLinear ModelsLogistic ModelsMaleMental HealthMiddle AgedMultivariate AnalysisNetherlandsPatient SatisfactionPeripheral Arterial DiseasePrognosisProspective StudiesQuality of LifeRisk FactorsSeverity of Illness IndexSex FactorsSocial BehaviorSocioeconomic FactorsSurveys and QuestionnairesUnited StatesConceptsPeripheral artery diseasePeripheral Artery QuestionnaireHealth statusArtery diseaseSymptoms of PADAnkle-brachial index valuesPAD-specific health statusSymptomatic peripheral artery diseaseDisease-specific health status measuresPAQ scoresPeripheral arterial diseaseSex differencesHealth status domainsInternational prospective studyPoor health statusHealth status measuresMultivariable linear regressionLower PAQ scoresBaseline characteristicsClinical characteristicsPAD symptomsTreatment satisfactionArterial diseaseProspective studyFemale sexSex Differences in 1-Year All-Cause Rehospitalization in Patients After Acute Myocardial Infarction
Dreyer RP, Dharmarajan K, Kennedy KF, Jones PG, Vaccarino V, Murugiah K, Nuti SV, Smolderen KG, Buchanan DM, Spertus JA, Krumholz HM. Sex Differences in 1-Year All-Cause Rehospitalization in Patients After Acute Myocardial Infarction. Circulation 2017, 135: 521-531. PMID: 28153989, PMCID: PMC5312975, DOI: 10.1161/circulationaha.116.024993.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAge-sex interactionHigh riskRehospitalization ratesClinical factorsMyocardial infarctionCox proportional hazards modelSignificant age-sex interactionCause rehospitalization rateSex differencesMedical record abstractionProportional hazards modelYears of ageFirst yearTRIUMPH studyCause rehospitalizationRecord abstractionPatient interviewsRehospitalizationUS CentersHazards modelPsychosocial factorsPhysician panelHealth statusPsychosocial state
2015
Depressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study
Smolderen KG, Strait KM, Dreyer RP, D'Onofrio G, Zhou S, Lichtman JH, Geda M, Bueno H, Beltrame J, Safdar B, Krumholz HM, Spertus JA. Depressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study. Journal Of The American Heart Association 2015, 4: e001424. PMID: 25836055, PMCID: PMC4579927, DOI: 10.1161/jaha.114.001424.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionDepressive symptomsLifetime historyMyocardial infarctionRisk factorsYoung acute myocardial infarctionYoung AMI Patients (VIRGO) studyMore cardiovascular risk factorsYoung womenCardiovascular risk factorsTime of admissionAdverse medical outcomesMore depressive symptomsLow socioeconomic profileAMI severityVIRGO StudyCardiovascular riskChart abstractionYounger patientsClinical profileRelevant sex differencesPatient profilesAMI admissionsMedical outcomesPatientsGender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis
Dreyer RP, Smolderen KG, Strait KM, Beltrame JF, Lichtman JH, Lorenze NP, D’Onofrio G, Bueno H, Krumholz HM, Spertus JA. Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2015, 5: 43-54. PMID: 25681487, PMCID: PMC4658311, DOI: 10.1177/2048872615568967.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrior coronary artery diseaseCoronary artery diseaseHealth statusMyocardial infarctionYounger patientsArtery diseaseCoronary artery disease historyDisease-specific health statusAcute myocardial infarction patientsAggressive symptom controlCornerstone of careWorse physical functionBaseline health statusMedical record abstractionVisual analog scaleHealth status outcomesMyocardial infarction patientsDisease-specific measuresMean health scoresLogistic regression analysisQuality of lifeHealth status informationGender differencesSymptom controlRisk Factors for Rehospitalization for Acute Coronary Syndromes and Unplanned Revascularization Following Acute Myocardial Infarction
Arnold SV, Smolderen KG, Kennedy KF, Li Y, Shore S, Stolker JM, Wang TY, Jones PG, Zhao Z, Spertus JA. Risk Factors for Rehospitalization for Acute Coronary Syndromes and Unplanned Revascularization Following Acute Myocardial Infarction. Journal Of The American Heart Association 2015, 4: e001352. PMID: 25666368, PMCID: PMC4345868, DOI: 10.1161/jaha.114.001352.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeAcute myocardial infarctionCoronary syndromeMyocardial infarctionRisk factorsHospital percutaneous coronary interventionCoronary artery bypass graftSecondary prevention therapiesArtery bypass graftRisk of rehospitalizationMortality risk scorePercutaneous coronary interventionPredictors of rehospitalizationRate of rehospitalizationBare metal stentsStrongest predictorMultivessel diseaseUnplanned revascularizationCause readmissionCoronary revascularizationCoronary interventionSubsequent revascularizationPrevention therapyRevascularization proceduresAMI registry
2014
Gender Differences in Health Status and Adverse Outcomes Among Patients With Peripheral Arterial Disease
Dreyer RP, van Zitteren M, Beltrame JF, Fitridge R, Denollet J, Vriens PW, Spertus JA, Smolderen KG. Gender Differences in Health Status and Adverse Outcomes Among Patients With Peripheral Arterial Disease. Journal Of The American Heart Association 2014, 4: e000863. PMID: 25537275, PMCID: PMC4330046, DOI: 10.1161/jaha.114.000863.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmbulatory Care FacilitiesCohort StudiesFemaleFollow-Up StudiesHealth StatusHealth Status IndicatorsHumansMaleMental HealthMiddle AgedMultivariate AnalysisNetherlandsPeripheral Arterial DiseasePhysical FitnessProportional Hazards ModelsRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex FactorsSurvival AnalysisTime FactorsConceptsPeripheral artery diseaseMajor adverse eventsPAD diagnosisAdverse eventsHealth statusMCS scoresLong-term major adverse eventsSelf-reported health statusBaseline clinical dataPeripheral arterial diseaseShort Form-12Time of presentationSubsequent adverse eventsPoor socio-economic statusMental health statusCardiovascular outcomesClinical characteristicsArtery diseaseVascular clinicArterial diseaseForm-12Independent determinantsInitial diagnosisAdverse outcomesPCS scoresPeripheral arterial disease, gender, and depression in the Heart and Soul Study
Grenon SM, Cohen BE, Smolderen K, Vittinghoff E, Whooley MA, Hiramoto J. Peripheral arterial disease, gender, and depression in the Heart and Soul Study. Journal Of Vascular Surgery 2014, 60: 396-403. PMID: 24661811, PMCID: PMC4199228, DOI: 10.1016/j.jvs.2014.02.013.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseRisk factorsArterial diseaseDevelopment of PADStable coronary artery diseaseGender-specific risk factorsNontraditional risk factorsProspective cohort studyWorse lipid profileHistory of smokingTraditional risk factorsCoronary artery diseaseStrongest independent factorRole of depressionLogistic regression modelsSoul StudyCohort studyInflammatory biomarkersArtery diseaseDiabetes mellitusElevated fibrinogenSimilar prevalenceLipid profileHigh prevalenceIndependent factors
2013
Psychological Distress and Medication Adherence
Smolderen KG, Whooley MA. Psychological Distress and Medication Adherence. Circulation Cardiovascular Quality And Outcomes 2013, 6: 615-616. PMID: 24221835, DOI: 10.1161/circoutcomes.113.000633.Peer-Reviewed Original Research
2010
Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms
Smolderen KG, Spertus JA, Vriens PW, Kranendonk S, Nooren M, Denollet J. Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms. Journal Of Vascular Surgery 2010, 52: 637-644. PMID: 20576397, DOI: 10.1016/j.jvs.2010.04.025.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAnkle Brachial IndexDepressionFemaleHealth Status DisparitiesHumansIncidenceLogistic ModelsMaleMiddle AgedNetherlandsOdds RatioPeripheral Vascular DiseasesProspective StudiesPsychiatric Status Rating ScalesRegistriesRisk AssessmentRisk FactorsSex FactorsTime FactorsConceptsPeripheral arterial diseaseSignificant depressive symptomsDepressive symptomsGender-age groupsYoung womenArterial diseaseSymptomatic peripheral arterial diseaseEpidemiological Studies Depression ScaleFourfold greater oddsVascular outpatient clinicAnkle-brachial indexPatients' depressive symptomsTime of diagnosisLogistic regression modelsImportant comorbidityPAD diagnosisPAD patientsClinical factorsDepression screeningOutpatient clinicCardiovascular diseaseDepression riskDepression ScaleAdditional adjustmentGreater oddsType D personality mediates the relationship between remembered parenting and perceived health.
van den Broek KC, Smolderen KG, Pedersen SS, Denollet J. Type D personality mediates the relationship between remembered parenting and perceived health. Journal Of The Academy Of Consultation-Liaison Psychiatry 2010, 51: 216-24. PMID: 20484719, DOI: 10.1176/appi.psy.51.3.216.Peer-Reviewed Original ResearchConceptsType D personalityD personalityHealth outcomesShort Form Health SurveyRemembered parentingGeneral Dutch populationBeck Depression InventoryAdverse childhood experiencesAdverse outcomesHospital AnxietyCardiovascular diseaseHealth SurveyDepression ScaleDepression InventoryDutch populationRemembered RelationshipOutcomesChildhood experiencesType DParent scaleAssociationHealth