2024
Predicting peripheral neuropathy following neoadjuvant therapy in patients with breast cancer.
Feiger B, Biancalana M, Shelton A, Blenman K, Lustberg M. Predicting peripheral neuropathy following neoadjuvant therapy in patients with breast cancer. Journal Of Clinical Oncology 2024, 42: e12639-e12639. DOI: 10.1200/jco.2024.42.16_suppl.e12639.Peer-Reviewed Original ResearchBreast cancer patientsNeoadjuvant chemotherapyPeripheral neuropathyNeoadjuvant therapyBreast cancerCancer patientsAdministration of neoadjuvant chemotherapyCohort of breast cancer patientsLikelihood of breast-conserving surgeryContrast-enhanced magnetic resonance imagingQuality of lifeDynamic contrast-enhanced magnetic resonance imagingBreast-conserving surgeryReduced tumor burdenTreatment-induced neuropathyOccurrence of neuropathyInduce peripheral neuropathyDensity of blood vesselsPatients' quality of lifeMagnetic resonance imagingAmeliorate neuropathyDCE-MRI dataTumor burdenCumulative toxic effectsIntratumoral vascularity
2022
Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood
Wall I, Boulat V, Shah A, Blenman KRM, Wu Y, Alberts E, Calado DP, Salgado R, Grigoriadis A. Leveraging the Dynamic Immune Environment Triad in Patients with Breast Cancer: Tumour, Lymph Node, and Peripheral Blood. Cancers 2022, 14: 4505. PMID: 36139665, PMCID: PMC9496983, DOI: 10.3390/cancers14184505.Peer-Reviewed Original ResearchBreast cancerPeripheral bloodImmune responseAnti-tumor responseSystemic immune responsesBreast cancer patientsPatient selection parametersEnvironment triadImmune profileLymph nodesImmunological featuresCancer patientsPrimary tumorDisease progressionImmune sitesSurvival rateCancerPatientsTumorsOverall responseBloodFuture studiesTreatmentSignificant overall responseMultiple sites
2021
Characterization of the tumor immune microenvironment of triple-negative breast cancer (TNBC) patients who self-identify as African American (AA) or non-African American (NonAA).
Blenman K, Marczyk M, Qing T, O'Meara T, Yaghoobi V, Pelekanou V, Bai Y, Reisenbichler E, Li X, Gunasekharan V, Ibrahim E, Rimm D, Pusztai L, Cole K. Characterization of the tumor immune microenvironment of triple-negative breast cancer (TNBC) patients who self-identify as African American (AA) or non-African American (NonAA). Journal Of Clinical Oncology 2021, 39: 564-564. DOI: 10.1200/jco.2021.39.15_suppl.564.Peer-Reviewed Original ResearchTriple-negative breast cancerTumor immune microenvironmentAA patientsImmune microenvironmentWhole-exome sequencingAfrican AmericansTriple-negative breast cancer patientsYale Cancer CenterImmune checkpoint inhibitorsPD-L1 positivityPD-L1 expressionYear of diagnosisBreast cancer patientsCytokines/chemokinesImmune cell compositionTumor mutational burdenGermline whole-exome sequencingAge of diagnosisNegative breast cancerCorresponding clinical dataAllograft rejection pathwayNon-African AmericansSomatic mutationsFatty acid metabolismCheckpoint inhibitors
2018
Sentinel lymph node B cells can predict disease-free survival in breast cancer patients
Blenman KRM, He TF, Frankel PH, Ruel NH, Schwartz EJ, Krag DN, Tan LK, Yim JH, Mortimer JE, Yuan Y, Lee PP. Sentinel lymph node B cells can predict disease-free survival in breast cancer patients. Npj Breast Cancer 2018, 4: 28. PMID: 30155518, PMCID: PMC6107630, DOI: 10.1038/s41523-018-0081-7.Peer-Reviewed Original ResearchSentinel lymph nodesTriple-negative breast cancerBreast cancer patientsB cellsLymph nodesCancer patientsImmune cellsBreast cancerNegative triple negative breast cancerTumor-negative patientsTumor-positive nodesDisease-free survivalAdditional prognostic informationTNM staging systemTumor invasion statusPositive nodesNegative patientsSentinel lymphDendritic cellsStaging systemPrognostic informationUnivariate analysisT cellsDiscovery cohortSeparate cohort
2017
Correlation of sentinel lymph node immune cells with disease-free survival and metastasis in breast cancer patients using 4-color chromogen-based immunohistochemistry and quantitative imaging microscopy
Blenman K. Correlation of sentinel lymph node immune cells with disease-free survival and metastasis in breast cancer patients using 4-color chromogen-based immunohistochemistry and quantitative imaging microscopy. The Journal Of Immunology 2017, 198: 197.7-197.7. DOI: 10.4049/jimmunol.198.supp.197.7.Peer-Reviewed Original ResearchDisease-free survivalShorter disease-free survivalOnly immune cellsBreast cancer patientsT cellsCancer cell invasionImmune cellsB cellsDistant metastasisCancer patientsDendritic cellsLocal metastasisCell invasionOdds of metastasisT cell reductionCancer cellsBreast cancer cohortSentinel lymphUnivariate analysisCancer cohortPatientsMetastasisLogistic regressionCell reductionSurvival