2023
Early intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial
Milgrom J, Hirshler Y, Holt C, Skouteris H, Galbally M, East C, Glover V, Reece J, O’Donnell K, Walker S, Malloy S, Gemmill A. Early intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial. BMC Psychology 2023, 11: 222. PMID: 37542332, PMCID: PMC10401817, DOI: 10.1186/s40359-023-01244-w.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyChild Behavior ChecklistChild outcomesBehavioral developmentMaternal depressionAntenatal depression treatmentChild developmental outcomesRevised Infant Behavior QuestionnaireInfant Behavior QuestionnaireActive psychological treatmentsMother-infant interactionAntenatal depressionAdditional secondary outcome measuresMonths of ageAdverse child outcomesOutcome measuresPsychological treatmentCBT programMental health disordersBehavioral therapyAnxiety symptomsBehavior ChecklistBehavioral problemsExternalising problemsInternalising scalesGenetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study
Henry M, Harvey R, Chen L, Meaney M, Nguyen T, Kao H, Rosberger Z, Frenkiel S, Hier M, Zeitouni A, Kost K, Mlynarek A, Richardson K, Greenwood C, Melnychuk D, Gold P, Chartier G, Black M, Mascarella M, MacDonald C, Sadeghi N, Sultanem K, Shenouda G, Cury F, O'Donnell K. Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study. Journal Of Affective Disorders 2023, 331: 149-157. PMID: 36948466, DOI: 10.1016/j.jad.2023.03.007.Peer-Reviewed Original ResearchConceptsSymptom burdenNeck cancerGenetic predispositionPolygenic risk scoresRisk scoreAnxiety disordersImmediate post-treatment periodMedical chart reviewDose of radiotherapyStructured Clinical InterviewHigher polygenic risk scoreLongitudinal studyProspective longitudinal studyLife-threatening diseaseDose-related responsePost-treatment periodChart reviewHADS anxietyCancer survivalHigh prevalencePrimary headHigh riskDSM disordersPatientsClinical Interview
2022
The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort
Pagès N, Gorgui J, Wang C, Wang X, Zhao JP, Tchuente V, Lacasse A, Côté S, King S, Muanda F, Mufike Y, Boucoiran I, Nuyt AM, Quach C, Ferreira E, Kaul P, Winquist B, O'Donnell KJ, Eltonsy S, Chateau D, Hanley G, Oberlander T, Kassai B, Mainbourg S, Bernatsky S, Vinet É, Brodeur-Doucet A, Demers J, Richebé P, Zaphiratos V, Bérard A. The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort. International Journal Of Environmental Research And Public Health 2022, 19: 12386. PMID: 36231687, PMCID: PMC9566261, DOI: 10.3390/ijerph191912386.Peer-Reviewed Original ResearchConceptsMaternal mental healthMental healthMean GAD-7 scorePregnant personsGAD-7 scoresNon-pandemic periodMental health assessmentCanada 2Public health policyLevel of depressionDepressive scoresMaternal depressionChinese cohortEDPS scoreCOVID-19 public health policiesCOVID-19 experienceHealth policyCohortSociodemographic variablesSelf-reported dataConception cohortsHealth assessmentCOVID-19COVID-19 pandemicScoresMaternal Prenatal Infection and Anxiety Predict Neurodevelopmental Outcomes in Middle Childhood
O’Connor T, Ciesla AA, Sefair AV, Thornburg LL, Brown AS, Glover V, O’Donnell K. Maternal Prenatal Infection and Anxiety Predict Neurodevelopmental Outcomes in Middle Childhood. Journal Of Psychopathology And Clinical Science 2022, 131: 422-434. PMID: 35238594, PMCID: PMC9069845, DOI: 10.1037/abn0000746.Peer-Reviewed Original ResearchConceptsChild neurodevelopmentSelf-report questionnairesPrenatal maternal anxietyPrediction of symptomsAttention problemsMiddle childhoodCommunication problemsAnxiety symptomsPerson testingAvon Longitudinal StudyEmotional symptomsPrenatal anxietyPrenatal riskPrenatal maternal infectionMaternal anxietyAnxietyMental healthLongitudinal studyPrenatal infectionSeparate linesLine of studyLarge prospective longitudinal cohort studyProspective longitudinal cohort studyChild CohortNeurodevelopment
2021
Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging
McGill MG, Pokhvisneva I, Clappison AS, McEwen LM, Beijers R, Tollenaar MS, Pham H, Kee MZL, Garg E, de Mendonça Filho EJ, Karnani N, Silveira PP, Kobor MS, de Weerth C, Meaney MJ, O'Donnell KJ. Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging. Biological Psychiatry 2021, 91: 303-312. PMID: 34756561, DOI: 10.1016/j.biopsych.2021.07.025.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnxietyChildDNA MethylationEpigenesis, GeneticEpigenomicsFemaleHumansMalePregnancyConceptsPrenatal maternal anxietyFetal originEpigenetic age accelerationMaternal anxietyAge accelerationPrenatal anxietyMental healthPrenatal maternal mental healthMaternal mental healthYears of ageGenetic risk factorsMonths of ageMental health supportMaternal prenatal anxietyRisk factorsLongitudinal cohortPrenatal adversityPregnant individualsLarge effect sizesLongitudinal assessmentHealth supportEffective mental health supportCohortPrenatal environmentLate childhood
2018
Maternal antenatal mood and child development: an exploratory study of treatment effects on child outcomes up to 5 years
Milgrom J, Holt CJ, Bleker LS, Holt C, Ross J, Ericksen J, Glover V, O’Donnell K, de Rooij SR, Gemmill AW. Maternal antenatal mood and child development: an exploratory study of treatment effects on child outcomes up to 5 years. Journal Of Developmental Origins Of Health And Disease 2018, 10: 221-231. PMID: 30303063, DOI: 10.1017/s2040174418000739.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyBehavior Rating ScaleChild BehaviorChild DevelopmentChild, PreschoolCognitive Behavioral TherapyDepressionFemaleFollow-Up StudiesHumansIntelligence TestsLongitudinal StudiesMaleMothersParent-Child RelationsPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsRandomized Controlled Trials as TopicSeverity of Illness IndexTreatment OutcomeConceptsChild Behavior ChecklistParenting Stress IndexNeurodevelopmental outcomesChild developmentHigher CBCLIntervention effectsAntenatal depression treatmentMaternal antenatal depressionAdverse neurodevelopmental outcomesInfant neurodevelopmental outcomesAge 2Age 5Cognitive behavioral therapyWPPSI-III scoresNon-significant trendPSI total scoreAntenatal moodAntenatal depressionRoutine careDepression treatmentOriginal cohortTreatment allocationIntervention groupLong-term effectsEffective treatmentPolygenic differential susceptibility to prenatal adversity
Belsky J, Pokhvisneva I, Rema ASS, Broekman BFP, Pluess M, O'Donnell KJ, Meaney MJ, Silveira PP. Polygenic differential susceptibility to prenatal adversity. Development And Psychopathology 2018, 31: 439-441. PMID: 30081968, DOI: 10.1017/s0954579418000378.Peer-Reviewed Original Research
2017
Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression
Silveira PP, Pokhvisneva I, Parent C, Cai S, Rema ASS, Broekman BFP, Rifkin-Graboi A, Pluess M, O'Donnell KJ, Meaney MJ. Cumulative prenatal exposure to adversity reveals associations with a broad range of neurodevelopmental outcomes that are moderated by a novel, biologically informed polygenetic score based on the serotonin transporter solute carrier family C6, member 4 (SLC6A4) gene expression. Development And Psychopathology 2017, 29: 1601-1617. PMID: 29162172, DOI: 10.1017/s0954579417001262.Peer-Reviewed Original ResearchConceptsEarly life adversityNeurodevelopmental outcomesPrenatal adversityChild Behavior ChecklistGenetic scoreAdversity scoreLife adversityCommunity birth cohortYears of agePervasive developmental problemsMaternal smokingGestational ageBirth weightLater riskPrenatal exposureAdverse exposuresBehavioral alterationsBirth cohortSerotonin transporter geneFetal periodPostnatal influencesPrefrontal cortexRelevant single nucleotide polymorphismsSerotonin transporterPrenatal lifeMaternal prenatal anxiety and child COMT genotype predict working memory and symptoms of ADHD
O'Donnell KJ, Glover V, Lahti J, Lahti M, Edgar RD, Räikkönen K, O'Connor TG. Maternal prenatal anxiety and child COMT genotype predict working memory and symptoms of ADHD. PLOS ONE 2017, 12: e0177506. PMID: 28614354, PMCID: PMC5470664, DOI: 10.1371/journal.pone.0177506.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyAttention Deficit Disorder with HyperactivityCatechol O-MethyltransferaseChildFemaleGene-Environment InteractionGenotypeHumansLongitudinal StudiesMaleMemory, Short-TermMothersPolymorphism, Single NucleotidePregnancyPrenatal Exposure Delayed EffectsProspective StudiesSelf ReportConceptsMaternal prenatal anxietySymptoms of ADHDPrenatal anxietyChildren's symptomsSelf-report measuresInter-individual differencesRs4680 genotypeIndividual differencesHyperactivity symptomsChildren's responsesADHDDevelopmental outcomesCOMT genotypeAnxietyAge 8 yearsMemoryVal/Val genotypeVal/ALSPAC cohortChild neurodevelopmentYears of ageFunctional genetic variationVal genotypeCOMTGene-environment interactions
2014
Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age
O'Donnell KJ, Glover V, Holbrook JD, O'Connor TG. Maternal prenatal anxiety and child brain-derived neurotrophic factor (BDNF) genotype: Effects on internalizing symptoms from 4 to 15 years of age. Development And Psychopathology 2014, 26: 1255-1266. PMID: 25422959, DOI: 10.1017/s095457941400100x.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor (BDNF) genePrenatal maternal anxietyYears of agePrenatal anxietyBDNF polymorphismMaternal anxietyBrain-derived neurotrophic factor (BDNF) genotypeNeurotrophic factor genotypeInternalizing symptomsNeurotrophic factor geneAge 15 yearsAvon Longitudinal StudyMaternal prenatal anxietyMaternal symptomsChild internalizing symptomsGene-environment interactionsClinical InterviewPopulation cohortHealth outcomesSymptomsDiagnostic assessmentPsychosocial risksDifficulties QuestionnaireAge 13Longitudinal studyThe persisting effect of maternal mood in pregnancy on childhood psychopathology
O'Donnell KJ, Glover V, Barker ED, O'Connor TG. The persisting effect of maternal mood in pregnancy on childhood psychopathology. Development And Psychopathology 2014, 26: 393-403. PMID: 24621564, DOI: 10.1017/s0954579414000029.Peer-Reviewed Original ResearchConceptsPrenatal anxietyMaternal moodPostnatal maternal moodLongitudinal studyMaternal prenatal anxietyLarge community samplePrenatal maternal moodOccasions of measurementPsychiatric symptomsChild mental disordersChild psychiatric symptomsEmotional problemsCommunity sampleAvon Longitudinal StudyEmotional symptomsChildhood psychopathologyPostnatal moodAge 4MoodAnxietyPersisting effectProgramming hypothesisMental disordersPrenatal depressionMajor models
2013
Maternal prenatal symptoms of depression and down regulation of placental monoamine oxidase A expression
Blakeley PM, Capron LE, Jensen AB, O'Donnell KJ, Glover V. Maternal prenatal symptoms of depression and down regulation of placental monoamine oxidase A expression. Journal Of Psychosomatic Research 2013, 75: 341-345. PMID: 24119940, DOI: 10.1016/j.jpsychores.2013.07.002.Peer-Reviewed Original ResearchConceptsPlacental functionPrenatal symptomsA ExpressionSymptoms of depressionMaternal trait anxietyPlacental monoamine oxidaseElective caesareanNeurodevelopmental outcomesFetal exposureMAO AMaternal symptomsPregnant womenMaternal moodMonoamine oxidase APlacental expressionMaternal depressionFetal bloodSymptomsTrophoblast tissueMonoamine oxidaseSpecific polyclonal antibodiesDepressionOxidase APsychometric testsPlacentaPrenatal maternal mood is associated with altered diurnal cortisol in adolescence
O’Donnell K, Glover V, Jenkins J, Browne D, Ben-Shlomo Y, Golding J, O’Connor T. Prenatal maternal mood is associated with altered diurnal cortisol in adolescence. Psychoneuroendocrinology 2013, 38: 1630-1638. PMID: 23433748, PMCID: PMC3695029, DOI: 10.1016/j.psyneuen.2013.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectAnxietyCircadian RhythmDepressionFemaleFollow-Up StudiesHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsSalivaSampling StudiesSecretory RateSeverity of Illness IndexSocioeconomic FactorsWakefulnessConceptsPrenatal anxietyDiurnal cortisolMaternal postnatal anxietyMaternal prenatal anxietyPrenatal maternal moodMultilevel model analysisAdolescent cortisolCortisol awakening responsePostnatal covariatesProspective longitudinal studyFlatter diurnal slopeCommunity samplePrenatal moodPostnatal anxietyMaternal moodCortisol samplesMaternal depressionAnxietyAwakening responseLongitudinal studyDiurnal slopePersisting effectPrenatal stressAnimal workALSPAC cohort
2011
Maternal prenatal anxiety and downregulation of placental 11β-HSD2
O’Donnell K, Jensen A, Freeman L, Khalife N, O’Connor T, Glover V. Maternal prenatal anxiety and downregulation of placental 11β-HSD2. Psychoneuroendocrinology 2011, 37: 818-826. PMID: 22001010, DOI: 10.1016/j.psyneuen.2011.09.014.Peer-Reviewed Original ResearchConceptsPlacental 11β-HSD2Maternal prenatal anxietyMaternal anxietyPlacental 11β-hydroxysteroid dehydrogenase type 2Prenatal stressPrenatal anxietyDepression self-rating scalePrenatal maternal moodAdverse neurodevelopmental outcomesDehydrogenase type 2Subset of casesElective caesareanNeurodevelopmental outcomesFetal exposureMaternal moodMaternal cortisolFetal programmingState anxietyAnimal studiesSelf-rating scaleFemale fetusesType 2MRNA expressionDownregulationCortisol
2010
Anxiety, depression and saliva cortisol in women with a medical disorder during pregnancy
King NM, Chambers J, O’Donnell K, Jayaweera SR, Williamson C, Glover VA. Anxiety, depression and saliva cortisol in women with a medical disorder during pregnancy. Archives Of Women's Mental Health 2010, 13: 339-345. PMID: 20101421, DOI: 10.1007/s00737-009-0139-5.Peer-Reviewed Original ResearchConceptsMedical disordersSaliva cortisolDiurnal saliva samplesAdverse pregnancy outcomesHigher EPDS scoresSubgroup of womenExtra psychological supportSelf-rating questionnaireVs. 35.2Antenatal womenHyperemesis gravidarumPregnancy outcomesEPDS scoresPregnant womenVs. 5.9Neurodevelopmental problemsCortisol levelsHealth professionalsPregnancySaliva samplesDisorder groupElevated levelsPsychological supportWomenDisorders
2009
Prenatal Stress and Neurodevelopment of the Child: Focus on the HPA Axis and Role of the Placenta
O’Donnell K, O’Connor T, Glover V. Prenatal Stress and Neurodevelopment of the Child: Focus on the HPA Axis and Role of the Placenta. Developmental Neuroscience 2009, 31: 285-292. PMID: 19546565, DOI: 10.1159/000216539.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHPA axisMaternal stressPrenatal stressAnimal studiesMaternal HPA axisAdverse neurodevelopmental outcomesRecent human studiesPartner relationship problemsNeurodevelopmental outcomesFetal exposureFetal neurodevelopmentMaternal cortisolHuman studiesPrenatal stressorsPlacentaBehavioral problemsMaternal environmentCortisolNeurodevelopmentChildrenRelationship problemsAnxietySimilar mechanismPregnancyMixed results