2022
Obesity and accelerated epigenetic aging in a high-risk cohort of children
Etzel L, Hastings WJ, Hall MA, Heim CM, Meaney MJ, Noll JG, O’Donnell K, Pokhvisneva I, Rose EJ, Schreier HMC, Shenk CE, Shalev I. Obesity and accelerated epigenetic aging in a high-risk cohort of children. Scientific Reports 2022, 12: 8328. PMID: 35585103, PMCID: PMC9117197, DOI: 10.1038/s41598-022-11562-5.Peer-Reviewed Original ResearchConceptsBody mass indexHigh-risk cohortHigher ageHigher body mass indexOngoing prospective studyBlood cell countChild Health StudyEpigenetic agingHigh-risk childrenPoor health outcomesMiddle-aged adultsMass indexProspective studyFuture morbidityBlood leukocytesMortality riskHealth StudyObesityHealth outcomesCell countCohortEarly lifeContinuous variablesChildrenBiological aging
2020
Genetically predicted gene expression of prefrontal DRD4 gene and the differential susceptibility to childhood emotional eating in response to positive environment
Barth B, Bizarro L, Miguel PM, Dubé L, Levitan R, O'Donnell K, Meaney MJ, Silveira PP. Genetically predicted gene expression of prefrontal DRD4 gene and the differential susceptibility to childhood emotional eating in response to positive environment. Appetite 2020, 148: 104594. PMID: 31927071, DOI: 10.1016/j.appet.2020.104594.Peer-Reviewed Original ResearchMeSH KeywordsAdultChild BehaviorChild DevelopmentChild, PreschoolCohort StudiesEatingEmotionsFamily ConflictFeeding BehaviorFemaleGene ExpressionGenetic Predisposition to DiseaseHumansHyperphagiaInfantInfant, NewbornMachine LearningMaleMother-Child RelationsMothersObesityReceptors, Dopamine D4SingaporeSocial EnvironmentConceptsPositive environmentEmotional eatingEating Behavior QuestionnaireChildren's Eating Behaviour QuestionnaireGenetic differential susceptibilityDopamine D4 receptor geneD4 receptor geneBehavior QuestionnaireMonths of agePositive outcomesDRD4 genePositive settingEatingDifferential susceptibilityMAVANFurther evidenceOutcome measuresDRD4Susceptibility stateAdverse environmentsIndividualsQuestionnaireMeasuresDesireEvidence