2024
Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment
Tchalova K, Lydon J, Atkinson L, Fleming A, Kennedy J, Lecompte V, Meaney M, Moss E, O’Donnell K, O’Donnell K, Silveira P, Sokolowski M, Steiner M, Bartz J. Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment. Translational Psychiatry 2024, 14: 181. PMID: 38580654, PMCID: PMC10997775, DOI: 10.1038/s41398-024-02888-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultCanadaCohort StudiesFemaleGenotypeHumansMother-Child RelationsPolymorphism, GeneticPolymorphism, Single NucleotideReceptors, Opioid, muConceptsMaternal sensitivityChild attachmentAttachment behaviorExpression of attachment behaviorLevels of maternal sensitivityOPRM1 A118G genotypeInfluence of maternal sensitivityNon-human animal researchAmbivalent attachment patternsStrange Situation paradigmMu-opioid receptor geneOPRM1 A118G polymorphismA118G genotypeChildren's attachment stylesMother-child interactionA118G polymorphismEndogenous opioid systemMinor G alleleSensitive maternal careMother-infant attachmentInfant rhesus macaquesG alleleC77G polymorphismReceptor geneSituation paradigm
2023
Early intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial
Milgrom J, Hirshler Y, Holt C, Skouteris H, Galbally M, East C, Glover V, Reece J, O’Donnell K, Walker S, Malloy S, Gemmill A. Early intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial. BMC Psychology 2023, 11: 222. PMID: 37542332, PMCID: PMC10401817, DOI: 10.1186/s40359-023-01244-w.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyChildCOVID-19DepressionEmotionsFemaleHumansInfantMother-Child RelationsPregnancyRandomized Controlled Trials as TopicConceptsCognitive behavioral therapyChild Behavior ChecklistChild outcomesBehavioral developmentMaternal depressionAntenatal depression treatmentChild developmental outcomesRevised Infant Behavior QuestionnaireInfant Behavior QuestionnaireActive psychological treatmentsMother-infant interactionAntenatal depressionAdditional secondary outcome measuresMonths of ageAdverse child outcomesOutcome measuresPsychological treatmentCBT programMental health disordersBehavioral therapyAnxiety symptomsBehavior ChecklistBehavioral problemsExternalising problemsInternalising scales
2020
Genetically predicted gene expression of prefrontal DRD4 gene and the differential susceptibility to childhood emotional eating in response to positive environment
Barth B, Bizarro L, Miguel PM, Dubé L, Levitan R, O'Donnell K, Meaney MJ, Silveira PP. Genetically predicted gene expression of prefrontal DRD4 gene and the differential susceptibility to childhood emotional eating in response to positive environment. Appetite 2020, 148: 104594. PMID: 31927071, DOI: 10.1016/j.appet.2020.104594.Peer-Reviewed Original ResearchMeSH KeywordsAdultChild BehaviorChild DevelopmentChild, PreschoolCohort StudiesEatingEmotionsFamily ConflictFeeding BehaviorFemaleGene ExpressionGenetic Predisposition to DiseaseHumansHyperphagiaInfantInfant, NewbornMachine LearningMaleMother-Child RelationsMothersObesityReceptors, Dopamine D4SingaporeSocial EnvironmentConceptsPositive environmentEmotional eatingEating Behavior QuestionnaireChildren's Eating Behaviour QuestionnaireGenetic differential susceptibilityDopamine D4 receptor geneD4 receptor geneBehavior QuestionnaireMonths of agePositive outcomesDRD4 genePositive settingEatingDifferential susceptibilityMAVANFurther evidenceOutcome measuresDRD4Susceptibility stateAdverse environmentsIndividualsQuestionnaireMeasuresDesireEvidence
2019
Dissecting maternal care: Patterns of maternal parenting in a prospective cohort study
Unternaehrer E, Cost KT, Bouvette‐Turcot A, Gaudreau H, Massicotte R, Dhir SK, Dass S, O'Donnell KJ, Gordon‐Green C, Atkinson L, Levitan RD, Wazana A, Steiner M, Lydon JE, Clark R, Fleming AS, Meaney MJ, Team T. Dissecting maternal care: Patterns of maternal parenting in a prospective cohort study. Journal Of Neuroendocrinology 2019, 31: e12784. PMID: 31442354, DOI: 10.1111/jne.12784.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultFemaleHumansMaternal BehaviorMother-Child RelationsMothersParentingProspective StudiesSelf ReportYoung AdultConceptsMaternal parentingParental brainChild outcomesMental healthMaternal parenting styleSelf-report measuresChild-reported symptomsAinsworth Sensitivity ScaleFactor analysisSelf-report questionnairesParenting variablesDifferent latent constructsSupportive parentingRelationship satisfactionAffectionate parentingMotivational componentParenting stylesExploratory factor analysisSchool readinessMultidimensional constructBehavioral problemsParentingBehavioral componentsCooperation taskMother-child bondingA Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment
Toepfer P, O'Donnell KJ, Entringer S, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C. A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 58: 1207-1216. PMID: 30858011, PMCID: PMC6733663, DOI: 10.1016/j.jaac.2019.03.006.Peer-Reviewed Original ResearchAdultAdult Survivors of Child AbuseAllelesDepression, PostpartumFemaleGene-Environment InteractionGenotypeHumansInfantMother-Child RelationsMothersObject AttachmentOxytocinPolymorphism, Single NucleotideQuantitative Trait LociReactive Attachment DisorderReceptors, OxytocinRegression AnalysisStress, PsychologicalYoung AdultDynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness
Toepfer P, O'Donnell KJ, Entringer S, Garg E, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C. Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness. Psychoneuroendocrinology 2019, 103: 156-162. PMID: 30690225, PMCID: PMC6554513, DOI: 10.1016/j.psyneuen.2019.01.013.Peer-Reviewed Original ResearchConceptsLate pregnancyMaternal behaviorMonths postpartumEarly postnatal developmentNovel potential biomarkersRace/ethnicityPregnancy inducesPeripheral bloodPregnancyMother-child dyadsPostnatal maternal behaviourPostnatal developmentPotential biomarkersSteroid hormonesDNA methylationSocioeconomic statusWhole bloodPromoter DNA methylationMother-child interactionPostpartumBloodDNA methylation changesOxytocinDNAm trajectoriesMaternal intrusiveness