2024
Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns
Dye C, Alschuler D, Wu H, Duarte C, Monk C, Belsky D, Lee S, O’Donnell K, Baccarelli A, Scorza P. Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns. JAMA Network Open 2024, 7: e2427063. PMID: 39120899, PMCID: PMC11316241, DOI: 10.1001/jamanetworkopen.2024.27063.Peer-Reviewed Original ResearchConceptsMaternal adverse childhood experiencesAdverse childhood experiencesEdinburgh Postnatal Depression ScaleAccessible Resource for Integrated Epigenomics StudiesEpigenetic age accelerationGestational age accelerationAssociated with epigenetic agingAvon Longitudinal Study of ParentsLongitudinal Study of ParentsPostnatal Depression ScalePrimary outcomeChildhood experiencesAvon Longitudinal StudyEpigenetic ageStudy of ParentsAge accelerationHigher ACE scoresCross-sectional studyEpigenetic clocksMother-offspring dyadsDepression ScaleHealth districtMother-child dyadsDNA methylation–based epigenetic clocksInvestigate depressionVariation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment
Tchalova K, Lydon J, Atkinson L, Fleming A, Kennedy J, Lecompte V, Meaney M, Moss E, O’Donnell K, O’Donnell K, Silveira P, Sokolowski M, Steiner M, Bartz J. Variation in the mu-opioid receptor gene (OPRM1) moderates the influence of maternal sensitivity on child attachment. Translational Psychiatry 2024, 14: 181. PMID: 38580654, PMCID: PMC10997775, DOI: 10.1038/s41398-024-02888-x.Peer-Reviewed Original ResearchConceptsMaternal sensitivityChild attachmentAttachment behaviorExpression of attachment behaviorLevels of maternal sensitivityOPRM1 A118G genotypeInfluence of maternal sensitivityNon-human animal researchAmbivalent attachment patternsStrange Situation paradigmMu-opioid receptor geneOPRM1 A118G polymorphismA118G genotypeChildren's attachment stylesMother-child interactionA118G polymorphismEndogenous opioid systemMinor G alleleSensitive maternal careMother-infant attachmentInfant rhesus macaquesG alleleC77G polymorphismReceptor geneSituation paradigm
2023
Perinatal Trajectories of Maternal Depressive Symptoms in Prospective, Community-Based Cohorts Across 3 Continents
Kee M, Cremaschi A, De Iorio M, Chen H, Montreuil T, Nguyen T, Côté S, O’Donnell K, Giesbrecht G, Letourneau N, Chan S, Meaney M. Perinatal Trajectories of Maternal Depressive Symptoms in Prospective, Community-Based Cohorts Across 3 Continents. JAMA Network Open 2023, 6: e2339942. PMID: 37883082, PMCID: PMC10603499, DOI: 10.1001/jamanetworkopen.2023.39942.Peer-Reviewed Original ResearchConceptsSelf-reported depressive symptomsMaternal depressive symptomsDepressive symptomsPerinatal periodPostnatal periodEdinburgh Postnatal Depression ScalePostnatal Depression ScaleEpidemiological Studies DepressionHealth policy guidelinesPublic health initiativesGroups of mothersCohort studyObservational cohortProspective cohortPregnancy influencesReferral guidelinesMultiple time pointsDepression ScaleMAIN OUTCOMEPregnancyPostnatal onsetStudies DepressionHealth initiativesTimely interventionCohortEarly intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial
Milgrom J, Hirshler Y, Holt C, Skouteris H, Galbally M, East C, Glover V, Reece J, O’Donnell K, Walker S, Malloy S, Gemmill A. Early intervention to prevent adverse child emotional and behavioural development following maternal depression in pregnancy: study protocol for a randomised controlled trial. BMC Psychology 2023, 11: 222. PMID: 37542332, PMCID: PMC10401817, DOI: 10.1186/s40359-023-01244-w.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyChild Behavior ChecklistChild outcomesBehavioral developmentMaternal depressionAntenatal depression treatmentChild developmental outcomesRevised Infant Behavior QuestionnaireInfant Behavior QuestionnaireActive psychological treatmentsMother-infant interactionAntenatal depressionAdditional secondary outcome measuresMonths of ageAdverse child outcomesOutcome measuresPsychological treatmentCBT programMental health disordersBehavioral therapyAnxiety symptomsBehavior ChecklistBehavioral problemsExternalising problemsInternalising scalesA Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes
Arcego D, Buschdorf J, O'Toole N, Wang Z, Barth B, Pokhvisneva I, Rayan N, Patel S, de Mendonça Filho E, Lee P, Tan J, Koh M, Sim C, Parent C, de Lima R, Clappison A, O'Donnell K, Dalmaz C, Arloth J, Provençal N, Binder E, Diorio J, Silveira P, Meaney M. A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes. Biological Psychiatry 2023, 95: 48-61. PMID: 37406925, DOI: 10.1016/j.biopsych.2023.06.028.Peer-Reviewed Original ResearchConceptsHippocampal dentate gyrusDentate gyrusPsychiatric disordersHuman hippocampal cellsBrain gray matter densityEarly adversitySingle nucleotide polymorphismsMultiple psychiatric conditionsEarly life adversityGray matter densityAdult female macaquesMental health outcomesTranscriptional activityGlucocorticoid exposureNucleotide polymorphismsLater psychosisStress mediatorsHippocampal cellsPsychotic disordersAnimal modelsHealth outcomesPsychiatric conditionsSignificant associationFemale macaquesMental healthMaternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems
Babineau V, Jolicoeur‐Martineau A, Szekely E, Green C, Sassi R, Gaudreau H, Levitan R, Lydon J, Steiner M, O'Donnell K, Kennedy J, Burack J, Wazana A. Maternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems. Developmental Psychobiology 2023, 65: e22395. PMID: 37338256, DOI: 10.1002/dev.22395.Peer-Reviewed Original ResearchConceptsMaternal prenatal depressionPolygenic risk scoresPrenatal depressionPsychiatric problemsChild psychiatric problemsComorbid psychiatric problemsChildhood psychiatric problemsMajor depressive disorderHigher dysregulationYears of lifeAttention deficit hyperactivity disorderDeficit hyperactivity disorderWeeks' gestationPsychiatric comorbidityPrenatal cohortDepressive disorderPostnatal depressionRisk scorePrenatal stressDepression symptomsMaternal educationGreater riskHyperactivity disorderDysregulationPolygenic riskTemperature variability and birthweight: Epidemiological evidence from Africa
Wang P, O'Donnell K, Warren J, Dubrow R, Chen K. Temperature variability and birthweight: Epidemiological evidence from Africa. Environment International 2023, 173: 107792. PMID: 36841185, DOI: 10.1016/j.envint.2023.107792.Peer-Reviewed Original ResearchFetal Programming and Public Policy
Glover V, O'Connor T, O'Donnell K. Fetal Programming and Public Policy. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 62: 618-620. PMID: 36608741, DOI: 10.1016/j.jaac.2022.11.010.Peer-Reviewed Original Research
2022
Attachment insecurity and the biological embedding of reproductive strategies: Investigating the role of cellular aging
Bolhuis E, Belsky J, Frankenhuis WE, Shalev I, Hastings WJ, Tollenaar MS, O'Donnell KJ, McGill MG, Pokhvisneva I, Lin DTS, MacIsaac JL, Kobor MS, de Weerth C, Beijers R. Attachment insecurity and the biological embedding of reproductive strategies: Investigating the role of cellular aging. Biological Psychology 2022, 175: 108446. PMID: 36272562, DOI: 10.1016/j.biopsycho.2022.108446.Peer-Reviewed Original ResearchReceptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study
Felt JM, Harrington KD, Ram N, O'Donnell KJ, Sliwinski MJ, Benson L, Zhang Z, Meaney MJ, Putnam FW, Noll JG, Shenk CE. Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study. The Journals Of Gerontology Series B 2022, 78: 585-595. PMID: 36190812, PMCID: PMC10066744, DOI: 10.1093/geronb/gbac158.Peer-Reviewed Original ResearchConceptsReceptive language abilityChild sexual abuseEarly life adversityLanguage abilityCognitive agingLife adversityPeabody Picture VocabularyPPVT-R scoresReceptive languageCognitive functioningPicture VocabularyComparison conditionNormative trajectoriesSexual abuseInterindividual differencesIndependent measuresMidlifeAdversityEpigenetic age accelerationDevelopment studiesQuadratic trendQuadratic growth modelAge accelerationEpigenetic agingAbilityThe Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort
Pagès N, Gorgui J, Wang C, Wang X, Zhao JP, Tchuente V, Lacasse A, Côté S, King S, Muanda F, Mufike Y, Boucoiran I, Nuyt AM, Quach C, Ferreira E, Kaul P, Winquist B, O'Donnell KJ, Eltonsy S, Chateau D, Hanley G, Oberlander T, Kassai B, Mainbourg S, Bernatsky S, Vinet É, Brodeur-Doucet A, Demers J, Richebé P, Zaphiratos V, Bérard A. The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort. International Journal Of Environmental Research And Public Health 2022, 19: 12386. PMID: 36231687, PMCID: PMC9566261, DOI: 10.3390/ijerph191912386.Peer-Reviewed Original ResearchConceptsMaternal mental healthMental healthMean GAD-7 scorePregnant personsGAD-7 scoresNon-pandemic periodMental health assessmentCanada 2Public health policyLevel of depressionDepressive scoresMaternal depressionChinese cohortEDPS scoreCOVID-19 public health policiesCOVID-19 experienceHealth policyCohortSociodemographic variablesSelf-reported dataConception cohortsHealth assessmentCOVID-19COVID-19 pandemicScoresMaternal Prenatal Infection and Anxiety Predict Neurodevelopmental Outcomes in Middle Childhood
O’Connor T, Ciesla AA, Sefair AV, Thornburg LL, Brown AS, Glover V, O’Donnell K. Maternal Prenatal Infection and Anxiety Predict Neurodevelopmental Outcomes in Middle Childhood. Journal Of Psychopathology And Clinical Science 2022, 131: 422-434. PMID: 35238594, PMCID: PMC9069845, DOI: 10.1037/abn0000746.Peer-Reviewed Original ResearchConceptsChild neurodevelopmentSelf-report questionnairesPrenatal maternal anxietyPrediction of symptomsAttention problemsMiddle childhoodCommunication problemsAnxiety symptomsPerson testingAvon Longitudinal StudyEmotional symptomsPrenatal anxietyPrenatal riskPrenatal maternal infectionMaternal anxietyAnxietyMental healthLongitudinal studyPrenatal infectionSeparate linesLine of studyLarge prospective longitudinal cohort studyProspective longitudinal cohort studyChild CohortNeurodevelopmentThe COVID-19 Pandemic Impacted Maternal Mental Health Differently Depending on Pregnancy Status and Trimester of Gestation
Bérard A, Gorgui J, Tchuente V, Lacasse A, Gomez YH, Côté S, King S, Muanda F, Mufike Y, Boucoiran I, Nuyt AM, Quach C, Ferreira E, Kaul P, Winquist B, O’Donnell K, Eltonsy S, Chateau D, Zhao JP, Hanley G, Oberlander T, Kassai B, Mainbourg S, Bernatsky S, Vinet É, Brodeur-Doucet A, Demers J, Richebé P, Zaphiratos V. The COVID-19 Pandemic Impacted Maternal Mental Health Differently Depending on Pregnancy Status and Trimester of Gestation. International Journal Of Environmental Research And Public Health 2022, 19: 2926. PMID: 35270623, PMCID: PMC8910614, DOI: 10.3390/ijerph19052926.Peer-Reviewed Original ResearchConceptsMaternal mental healthTrimester of gestationMental healthMaternal depressionPregnancy statusMultivariate logistic regression modelDepressive symptom scoresPost-partum periodSevere maternal depressionCOVID-19 pandemicMental health measuresLogistic regression modelsAnxiety/stressPreterm birthSymptom scoresPregnant womenSevere depressionMaternal anxietyHealth measuresPregnant personsSignificant predictorsSociodemographic indicatorsTrimesterPregnancyCognitive problems
2021
Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife
Shenk CE, Felt JM, Ram N, O'Donnell KJ, Sliwinski MJ, Pokhvisneva I, Benson L, Meaney MJ, Putnam FW, Noll JG. Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife. Psychoneuroendocrinology 2021, 136: 105606. PMID: 34896740, PMCID: PMC8724404, DOI: 10.1016/j.psyneuen.2021.105606.Peer-Reviewed Original ResearchConceptsEarly life adversityEpigenetic age accelerationChildhood sexual abuseCortisol trajectoriesLife adversityAge accelerationCortisol concentrationsBiological embedding modelProspective cohort studyPeak cortisol levelsHPA axis activitySubstantiated childhood sexual abuseEarly ageCohort studyAdulthood healthHPA axisAdrenal axisCortisol secretionCsA exposureCortisol levelsPotential indicationsSexual abuseMultiple biological systemsSubsequent occasionsBiological embeddingMaternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging
McGill MG, Pokhvisneva I, Clappison AS, McEwen LM, Beijers R, Tollenaar MS, Pham H, Kee MZL, Garg E, de Mendonça Filho EJ, Karnani N, Silveira PP, Kobor MS, de Weerth C, Meaney MJ, O'Donnell KJ. Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging. Biological Psychiatry 2021, 91: 303-312. PMID: 34756561, DOI: 10.1016/j.biopsych.2021.07.025.Peer-Reviewed Original ResearchConceptsPrenatal maternal anxietyFetal originEpigenetic age accelerationMaternal anxietyAge accelerationPrenatal anxietyMental healthPrenatal maternal mental healthMaternal mental healthYears of ageGenetic risk factorsMonths of ageMental health supportMaternal prenatal anxietyRisk factorsLongitudinal cohortPrenatal adversityPregnant individualsLarge effect sizesLongitudinal assessmentHealth supportEffective mental health supportCohortPrenatal environmentLate childhoodSalivary cytokine cluster moderates the association between caregivers perceived stress and emotional functioning in youth
Parent C, Pokhvisneva I, de Mendonça Filho EJ, O'Donnell KJ, Meaney MJ, Kee MZL, Thng G, Wing H, Adler NE, Keeton V, Pantell MS, Hessler D, Gottlieb LM, Silveira PP. Salivary cytokine cluster moderates the association between caregivers perceived stress and emotional functioning in youth. Brain Behavior And Immunity 2021, 94: 125-137. PMID: 33662503, DOI: 10.1016/j.bbi.2021.02.025.Peer-Reviewed Original ResearchConceptsCaregivers' perceived stressIL-1βIL-6Cytokine clusterChild Behavior ChecklistEmotional functioningIL-8 cytokine levelsChild emotional functioningPediatric clinic visitsProspective birth cohortHyperactivity problemsEarly life stressPerceived stressPotential intergenerational effectsUCSF cohortSystemic inflammationClinic visitsCytokine levelsInflammation levelsSalivary levelsAttention Deficit Hyperactivity ProblemsIL-8Pediatric QualityLife InventoryBirth cohortImpact of parental socioeconomic status on offspring’s mental health: protocol for a longitudinal community-based study
Li M, O'Donnell KJ, Caron J, D'Arcy C, Meng X. Impact of parental socioeconomic status on offspring’s mental health: protocol for a longitudinal community-based study. BMJ Open 2021, 11: e038409. PMID: 33593762, PMCID: PMC7888321, DOI: 10.1136/bmjopen-2020-038409.Peer-Reviewed Original ResearchConceptsOffspring's mental healthEpigenetic Age Acceleration and Risk for Posttraumatic Stress Disorder following Exposure to Substantiated Child Maltreatment
Shenk CE, O’Donnell K, Pokhvisneva I, Kobor MS, Meaney MJ, Bensman HE, Allen EK, Olson AE. Epigenetic Age Acceleration and Risk for Posttraumatic Stress Disorder following Exposure to Substantiated Child Maltreatment. Journal Of Clinical Child & Adolescent Psychology 2021, 51: 651-661. PMID: 33471576, PMCID: PMC8289945, DOI: 10.1080/15374416.2020.1864738.Peer-Reviewed Original ResearchInternalizing symptoms associate with the pace of epigenetic aging in childhood
Tollenaar MS, Beijers R, Garg E, Nguyen TTT, Lin DTS, MacIsaac JL, Shalev I, Kobor MS, Meaney MJ, O'Donnell KJ, de Weerth C. Internalizing symptoms associate with the pace of epigenetic aging in childhood. Biological Psychology 2021, 159: 108021. PMID: 33460784, DOI: 10.1016/j.biopsycho.2021.108021.Peer-Reviewed Original ResearchConceptsAdvanced biological agingChildhood psychiatric symptomsAge 6Longitudinal cohort studyInternalizing symptomsBiological agingChild mental healthCohort studyBuccal epithelial cellsPsychiatric symptomsSymptomsMental healthEpithelial cellsInternalizing disordersStatistical significanceAge 2.5Highest EAAExternalizing symptomsChildhoodEpigenetic agingHorvath clockGenome-wide DNA methylationEAADCC gene network in the prefrontal cortex is associated with total brain volume in childhood
Morgunova A, Pokhvisneva I, Nolvi S, Entringer S, Wadhwa P, Gilmore J, Styner M, Buss C, Sassi RB, Hall GBC, O'Donnell KJ, Meaney MJ, Silveira PP, Flores CA. DCC gene network in the prefrontal cortex is associated with total brain volume in childhood. Journal Of Psychiatry And Neuroscience 2021, 46: e154-e163. PMID: 33206040, PMCID: PMC7955849, DOI: 10.1503/jpn.200081.Peer-Reviewed Original ResearchConceptsTotal brain volumeExpression-based polygenic risk scoreBrain volumePrefrontal cortexSingle nucleotide polymorphismsHigher total brain volumeCommunity-based cohortChildren 1.5Polygenic risk scoresMaternal adversityRisk scoreIndependent cohortReplication cohortCohortCortexBrain developmentChildren 8Donor databaseSmall sample sizeEffect sizeReplication analysis