2023
Maternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems
Babineau V, Jolicoeur‐Martineau A, Szekely E, Green C, Sassi R, Gaudreau H, Levitan R, Lydon J, Steiner M, O'Donnell K, Kennedy J, Burack J, Wazana A. Maternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems. Developmental Psychobiology 2023, 65: e22395. PMID: 37338256, DOI: 10.1002/dev.22395.Peer-Reviewed Original ResearchMeSH KeywordsChild, PreschoolComorbidityDepressionDepression, PostpartumDepressive Disorder, MajorFemaleHumansInfantMaleMothersPregnancyConceptsMaternal prenatal depressionPolygenic risk scoresPrenatal depressionPsychiatric problemsChild psychiatric problemsComorbid psychiatric problemsChildhood psychiatric problemsMajor depressive disorderHigher dysregulationYears of lifeAttention deficit hyperactivity disorderDeficit hyperactivity disorderWeeks' gestationPsychiatric comorbidityPrenatal cohortDepressive disorderPostnatal depressionRisk scorePrenatal stressDepression symptomsMaternal educationGreater riskHyperactivity disorderDysregulationPolygenic risk
2022
To what extent do social support and mastery mediate the association between childhood maltreatment and depression? A sequential causal mediation analysis
Su Y, Li M, D'Arcy C, Caron J, O'Donnell K, Meng X. To what extent do social support and mastery mediate the association between childhood maltreatment and depression? A sequential causal mediation analysis. Epidemiology And Psychiatric Sciences 2022, 31: e77. PMID: 36263598, PMCID: PMC9677445, DOI: 10.1017/s2045796022000609.Peer-Reviewed Original ResearchMeSH KeywordsChildChild AbuseDepressionDepressive Disorder, MajorHumansMediation AnalysisSocial SupportConceptsMajor depressionLongitudinal population-based studySocial supportPopulation-based studyDevelopment of depressionSequential causal mediation analysisMaltreatment subtypesChildhood maltreatment subtypesPsychosocial attributesPotential confoundingSubsequent depressionSubtypesCausal mediation analysisDepressionScientific evidenceChildhood maltreatmentVicious cycleIndependent roleAssociationDirect effectMediation analysisStudied variablesMajor contributorMaltreatmentIntegrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach
Meng X, Wang M, O’Donnell K, Caron J, Meaney MJ, Li Y. Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach. Translational Psychiatry 2022, 12: 240. PMID: 35676267, PMCID: PMC9177831, DOI: 10.1038/s41398-022-02015-8.Peer-Reviewed Original ResearchMeSH KeywordsCanadaDepressive Disorder, MajorGenetic Predisposition to DiseaseHumansPhenotypePolymorphism, Single NucleotideConceptsMajor depressive disorderRisk of MDDDepressive disorderMDD subtypesMDD diagnosisRisk categorizationMajor public health problemLongitudinal community-based cohortCommunity-based cohortRisk prediction toolsGenetic variantsPublic health problemPrevalent mental disordersRisk prediction modelMDD cohortMDD patientsGenetic predispositionHealth problemsEarly identificationMental disordersMDD casesPotential genetic variantsDisordersCohortSubtypesSpecific and cumulative lifetime stressors in the aetiology of major depression: A longitudinal community-based population study
Su Y, D'Arcy C, Li M, O'Donnell K, Caron J, Meaney M, Meng X. Specific and cumulative lifetime stressors in the aetiology of major depression: A longitudinal community-based population study. Epidemiology And Psychiatric Sciences 2022, 31: e3. PMID: 35078547, PMCID: PMC8851045, DOI: 10.1017/s2045796021000779.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDepressionDepressive Disorder, MajorHumansLife Change EventsStress, PsychologicalConceptsGenetic predispositionSubsequent depressionStressful life eventsLifetime stressorsLongitudinal community-based cohort studyPsychosocial stressorsCommunity-based cohort studyCommunity-based population studyStressful eventsMental illness preventionMultivariate logistic regressionHealth-related factorsDevelopment of depressionChildhood maltreatmentMental health promotionEtiology of depressionPresent studyStressful experiencesLife eventsChild-parent bondingCumulative stressful experiencesSouthwest of MontrealPolygenetic risk scoresCohort studySocio-demographic characteristics
2018
PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores
Chen LM, Yao N, Garg E, Zhu Y, Nguyen TTT, Pokhvisneva I, Hari Dass SA, Unternaehrer E, Gaudreau H, Forest M, McEwen LM, MacIsaac JL, Kobor MS, Greenwood CMT, Silveira PP, Meaney MJ, O’Donnell K. PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores. BMC Bioinformatics 2018, 19: 295. PMID: 30089455, PMCID: PMC6083617, DOI: 10.1186/s12859-018-2289-9.Peer-Reviewed Original Research
2017
Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk
Qiu A, Shen M, Buss C, Chong YS, Kwek K, Saw SM, Gluckman PD, Wadhwa PD, Entringer S, Styner M, Karnani N, Heim CM, O'Donnell KJ, Holbrook JD, Fortier MV, Meaney MJ, . Effects of Antenatal Maternal Depressive Symptoms and Socio-Economic Status on Neonatal Brain Development are Modulated by Genetic Risk. Cerebral Cortex 2017, 27: 1-13. PMID: 28334351, PMCID: PMC6057508, DOI: 10.1093/cercor/bhx065.Peer-Reviewed Original ResearchMeSH KeywordsAsian PeopleBrainBrain MappingCohort StudiesComputational BiologyDepressive Disorder, MajorFemaleFetal DevelopmentGene Regulatory NetworksGenotypeGestational AgeHumansImage Processing, Computer-AssistedInfant, NewbornMagnetic Resonance ImagingMaleMaternal-Fetal RelationsPolymorphism, Single NucleotidePregnancyPrenatal Exposure Delayed EffectsSocial ClassConceptsMaternal depressive symptomsDepressive symptomsHippocampal volumeRight amygdalaRight hippocampal volumeGlutamate receptor activityNeonatal brain developmentMajor depressive disorderRight amygdala volumeMother-infant dyadsFetal neurodevelopmentAmericas cohortAsian cohortDepressive disorderNeurotrophic signalingRight hippocampusCognitive-emotional functionRisk scoreAmygdala volumeSignificant interactionFetal developmentVentromedial prefrontal cortexSocio-economic statusBrain regionsReceptor activity
2015
Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways
Shenk CE, Griffin AM, O'Donnell KJ. Symptoms of major depressive disorder subsequent to child maltreatment: Examining change across multiple levels of analysis to identify transdiagnostic risk pathways. Development And Psychopathology 2015, 27: 1503-1514. PMID: 26535940, PMCID: PMC4774890, DOI: 10.1017/s0954579415000905.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlpha-AmylasesChild AbuseDepressive Disorder, MajorEmotionsFemaleHumansHydrocortisoneRiskSelf-ControlYoung AdultConceptsMajor depressive disorderMDD symptomsDepressive disorderRisk pathwaysChild maltreatmentPrevalent psychiatric conditionChild maltreatment populationSubstantiated child maltreatmentPsychiatric conditionsSymptomsClinical interventionsSaliva samplesLaboratory stressorDirect targetingFemale adolescentsCertain childrenChildrenEmotion regulationDisordersComparison conditionSignificant indirect effectCurrent studyMaltreatmentPathwayEmotion dysregulation