2022
Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study
Felt JM, Harrington KD, Ram N, O'Donnell KJ, Sliwinski MJ, Benson L, Zhang Z, Meaney MJ, Putnam FW, Noll JG, Shenk CE. Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study. The Journals Of Gerontology Series B 2022, 78: 585-595. PMID: 36190812, PMCID: PMC10066744, DOI: 10.1093/geronb/gbac158.Peer-Reviewed Original ResearchConceptsReceptive language abilityChild sexual abuseEarly life adversityLanguage abilityCognitive agingLife adversityPeabody Picture VocabularyPPVT-R scoresReceptive languageCognitive functioningPicture VocabularyComparison conditionNormative trajectoriesSexual abuseInterindividual differencesIndependent measuresMidlifeAdversityEpigenetic age accelerationDevelopment studiesQuadratic trendQuadratic growth modelAge accelerationEpigenetic agingAbility
2018
The early care environment and DNA methylome variation in childhood
Garg E, Chen L, Nguyen TTT, Pokhvisneva I, Chen LM, Unternaehrer E, MacIsaac JL, McEwen LM, Mah SM, Gaudreau H, Levitan R, Moss E, Sokolowski MB, Kennedy JL, Steiner MS, Meaney MJ, Holbrook JD, Silveira PP, Karnani N, Kobor MS, O'Donnell KJ. The early care environment and DNA methylome variation in childhood. Development And Psychopathology 2018, 30: 891-903. PMID: 30068421, DOI: 10.1017/s0954579418000627.Peer-Reviewed Original ResearchConceptsGenome-wide DNA methylationDNA methylationGenetic variationGenetic dataEarly care environmentsMethylome variationInfant attachment styleInfant attachmentEpigenetic modificationsAttachment styleBuccal epithelial samplesMethylationMolecular signaturesPrenatal adversityGenetic contributionInfant developmentChild genetic variationInfant cognitive developmentDisorganized attachment styleLater mental health problemsNegative effectsEarly intervention programsChild mental healthMental health problemsCognitive development