2019
A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions
Dass S, McCracken K, Pokhvisneva I, Chen LM, Garg E, Nguyen TTT, Wang Z, Barth B, Yaqubi M, McEwen LM, MacIsaac JL, Diorio J, Kobor MS, O'Donnell KJ, Meaney MJ, Silveira PP. A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions. EBioMedicine 2019, 42: 188-202. PMID: 30922963, PMCID: PMC6491717, DOI: 10.1016/j.ebiom.2019.03.051.Peer-Reviewed Original ResearchMeSH KeywordsBrainEndophenotypesFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHippocampusHumansMalePhenotypePolymorphism, Single NucleotideReceptor, InsulinReproducibility of ResultsConceptsCognitive performancePolygenic scoresRelated mental disordersChild impulsivityIndividual differencesSpecific brain regionsInhibitory controlNeurobiological mechanismsCommunity sampleBrain regionsConventional GWASMesocorticolimbic systemImpulsivityMental disordersPsychopathologyAddictionNeural functionEndophenotypesAlzheimer's diseaseScoresADHDDisordersMemoryFunctioningGenetic score
2018
Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time
Forest M, O'Donnell KJ, Voisin G, Gaudreau H, MacIsaac JL, McEwen LM, Silveira PP, Steiner M, Kobor MS, Meaney MJ, Greenwood CMT. Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time. Epigenetics 2018, 13: 19-32. PMID: 29381404, PMCID: PMC5837078, DOI: 10.1080/15592294.2017.1411443.Peer-Reviewed Original ResearchBrain-Derived Neurotrophic FactorCanadaCatechol O-MethyltransferaseDNA MethylationDried Blood Spot TestingEpigenesis, GeneticFemaleHumansMaleMouth MucosaNetherlandsOligonucleotide Array Sequence AnalysisReceptors, Dopamine D2Receptors, Dopamine D4Receptors, OxytocinReproducibility of ResultsSerotonin Plasma Membrane Transport ProteinsTime Factors