2014
Cortisol awakening response and subsequent depression: prospective longitudinal study
Carnegie R, Araya R, Ben-Shlomo Y, Glover V, O'Connor TG, O'Donnell KJ, Pearson R, Lewis G. Cortisol awakening response and subsequent depression: prospective longitudinal study. The British Journal Of Psychiatry 2014, 204: 137-143. PMID: 24311550, PMCID: PMC3909839, DOI: 10.1192/bjp.bp.113.126250.Peer-Reviewed Original ResearchConceptsCortisol awakening responseSubsequent depressionSalivary cortisolAwakening responseOdds ratioTime pointsICD-10 criteriaLongitudinal studyProspective longitudinal studyAvon Longitudinal StudyShort-term riskSubsequent depressive illnessLarge population cohortAdrenal functionDepressive illnessClinical significancePopulation cohortElevated cortisolCortisolLogistic regressionCortisol measuresStress reactivityDepressionDiurnal dropAssociation
2013
Stressful events and psychological difficulties: testing alternative candidates for sensitivity
Laceulle OM, O’Donnell K, Glover V, O’Connor T, Ormel J, van Aken MA, Nederhof E. Stressful events and psychological difficulties: testing alternative candidates for sensitivity. European Child & Adolescent Psychiatry 2013, 23: 103-113. PMID: 23756816, DOI: 10.1007/s00787-013-0436-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffective SymptomsAnxiety DisordersChildChild DevelopmentChild of Impaired ParentsChild, PreschoolDisease SusceptibilityFemaleHumansLife Change EventsMaleMothersPregnancyPrenatal Exposure Delayed EffectsProspective StudiesRisk FactorsSex FactorsSocial EnvironmentSocioeconomic FactorsStress, PsychologicalSurveys and QuestionnairesTime FactorsConceptsPsychological difficultiesStressful eventsDifficult temperamentPrenatal anxietyLife eventsSources of sensitivityStressful life eventsPrenatal maternal anxietyChild developmentReciprocal associationsAge 7Maternal anxietyAge 4Child's ageTemperamentLongitudinal studyStress exposureAnxietyEarly childhoodCurrent studyConsistent evidenceChildrenPrior workDifficultiesAdditional researchPrenatal maternal mood is associated with altered diurnal cortisol in adolescence
O’Donnell K, Glover V, Jenkins J, Browne D, Ben-Shlomo Y, Golding J, O’Connor T. Prenatal maternal mood is associated with altered diurnal cortisol in adolescence. Psychoneuroendocrinology 2013, 38: 1630-1638. PMID: 23433748, PMCID: PMC3695029, DOI: 10.1016/j.psyneuen.2013.01.008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectAnxietyCircadian RhythmDepressionFemaleFollow-Up StudiesHumansHydrocortisoneHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsSalivaSampling StudiesSecretory RateSeverity of Illness IndexSocioeconomic FactorsWakefulnessConceptsPrenatal anxietyDiurnal cortisolMaternal postnatal anxietyMaternal prenatal anxietyPrenatal maternal moodMultilevel model analysisAdolescent cortisolCortisol awakening responsePostnatal covariatesProspective longitudinal studyFlatter diurnal slopeCommunity samplePrenatal moodPostnatal anxietyMaternal moodCortisol samplesMaternal depressionAnxietyAwakening responseLongitudinal studyDiurnal slopePersisting effectPrenatal stressAnimal workALSPAC cohort
2011
Maternal prenatal anxiety and downregulation of placental 11β-HSD2
O’Donnell K, Jensen A, Freeman L, Khalife N, O’Connor T, Glover V. Maternal prenatal anxiety and downregulation of placental 11β-HSD2. Psychoneuroendocrinology 2011, 37: 818-826. PMID: 22001010, DOI: 10.1016/j.psyneuen.2011.09.014.Peer-Reviewed Original ResearchConceptsPlacental 11β-HSD2Maternal prenatal anxietyMaternal anxietyPlacental 11β-hydroxysteroid dehydrogenase type 2Prenatal stressPrenatal anxietyDepression self-rating scalePrenatal maternal moodAdverse neurodevelopmental outcomesDehydrogenase type 2Subset of casesElective caesareanNeurodevelopmental outcomesFetal exposureMaternal moodMaternal cortisolFetal programmingState anxietyAnimal studiesSelf-rating scaleFemale fetusesType 2MRNA expressionDownregulationCortisol