2014
The persisting effect of maternal mood in pregnancy on childhood psychopathology
O'Donnell KJ, Glover V, Barker ED, O'Connor TG. The persisting effect of maternal mood in pregnancy on childhood psychopathology. Development And Psychopathology 2014, 26: 393-403. PMID: 24621564, DOI: 10.1017/s0954579414000029.Peer-Reviewed Original ResearchConceptsPrenatal anxietyMaternal moodPostnatal maternal moodLongitudinal studyMaternal prenatal anxietyLarge community samplePrenatal maternal moodOccasions of measurementPsychiatric symptomsChild mental disordersChild psychiatric symptomsEmotional problemsCommunity sampleAvon Longitudinal StudyEmotional symptomsChildhood psychopathologyPostnatal moodAge 4MoodAnxietyPersisting effectProgramming hypothesisMental disordersPrenatal depressionMajor models
2013
Stressful events and psychological difficulties: testing alternative candidates for sensitivity
Laceulle OM, O’Donnell K, Glover V, O’Connor T, Ormel J, van Aken MA, Nederhof E. Stressful events and psychological difficulties: testing alternative candidates for sensitivity. European Child & Adolescent Psychiatry 2013, 23: 103-113. PMID: 23756816, DOI: 10.1007/s00787-013-0436-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffective SymptomsAnxiety DisordersChildChild DevelopmentChild of Impaired ParentsChild, PreschoolDisease SusceptibilityFemaleHumansLife Change EventsMaleMothersPregnancyPrenatal Exposure Delayed EffectsProspective StudiesRisk FactorsSex FactorsSocial EnvironmentSocioeconomic FactorsStress, PsychologicalSurveys and QuestionnairesTime FactorsConceptsPsychological difficultiesStressful eventsDifficult temperamentPrenatal anxietyLife eventsSources of sensitivityStressful life eventsPrenatal maternal anxietyChild developmentReciprocal associationsAge 7Maternal anxietyAge 4Child's ageTemperamentLongitudinal studyStress exposureAnxietyEarly childhoodCurrent studyConsistent evidenceChildrenPrior workDifficultiesAdditional research
2011
Maternal prenatal anxiety and downregulation of placental 11β-HSD2
O’Donnell K, Jensen A, Freeman L, Khalife N, O’Connor T, Glover V. Maternal prenatal anxiety and downregulation of placental 11β-HSD2. Psychoneuroendocrinology 2011, 37: 818-826. PMID: 22001010, DOI: 10.1016/j.psyneuen.2011.09.014.Peer-Reviewed Original ResearchConceptsPlacental 11β-HSD2Maternal prenatal anxietyMaternal anxietyPlacental 11β-hydroxysteroid dehydrogenase type 2Prenatal stressPrenatal anxietyDepression self-rating scalePrenatal maternal moodAdverse neurodevelopmental outcomesDehydrogenase type 2Subset of casesElective caesareanNeurodevelopmental outcomesFetal exposureMaternal moodMaternal cortisolFetal programmingState anxietyAnimal studiesSelf-rating scaleFemale fetusesType 2MRNA expressionDownregulationCortisol