2023
Maternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems
Babineau V, Jolicoeur‐Martineau A, Szekely E, Green C, Sassi R, Gaudreau H, Levitan R, Lydon J, Steiner M, O'Donnell K, Kennedy J, Burack J, Wazana A. Maternal prenatal depression is associated with dysregulation over the first five years of life moderated by child polygenic risk for comorbid psychiatric problems. Developmental Psychobiology 2023, 65: e22395. PMID: 37338256, DOI: 10.1002/dev.22395.Peer-Reviewed Original ResearchConceptsMaternal prenatal depressionPolygenic risk scoresPrenatal depressionPsychiatric problemsChild psychiatric problemsComorbid psychiatric problemsChildhood psychiatric problemsMajor depressive disorderHigher dysregulationYears of lifeAttention deficit hyperactivity disorderDeficit hyperactivity disorderWeeks' gestationPsychiatric comorbidityPrenatal cohortDepressive disorderPostnatal depressionRisk scorePrenatal stressDepression symptomsMaternal educationGreater riskHyperactivity disorderDysregulationPolygenic risk
2018
Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study
Braithwaite EC, Hill J, Pickles A, Glover V, O’Donnell K, Sharp H. Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study. Journal Of Developmental Origins Of Health And Disease 2018, 9: 425-431. PMID: 29631648, PMCID: PMC6075696, DOI: 10.1017/s2040174418000181.Peer-Reviewed Original ResearchConceptsInfant birth weightBirth weightPrenatal cortisolMaternal prenatal cortisolWirral Child HealthFetal growthChild healthAffective disordersDevelopment Study cohortGeneral population estimatesSex-dependent mannerSex-specific mechanismsInverse probability weightsSex-specific effectsCurve cortisolWeeks' gestationGestational ageHospital recordsStudy cohortRisk stratifierFetal programmingGeneral populationGlucocorticoid mechanismsSignificant associationCortisol