2023
Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders
Felt J, Yusupov N, Harrington K, Fietz J, Zhang Z, Sliwinski M, Ram N, O'Donnell K, Group B, Meaney M, Putnam F, Noll J, Binder E, Shenk C. Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders. Neurobiology Of Stress 2023, 27: 100577. PMID: 37885906, PMCID: PMC10597797, DOI: 10.1016/j.ynstr.2023.100577.Peer-Reviewed Original ResearchEarly life adversityPsychiatric disordersEpigenetic age accelerationLife adversityAge accelerationProspective cohort studyBiological agingNon-abused controlsCohort studyNeurocognitive screeningPeripheral bloodCommunity cohortNeurocognitive declineIndependent cohortCognitive declineEarly screeningMental disordersCohortGrimAge clockDisordersBiomarkersLower general cognitive abilityEarly declineNeurocognitive abilitiesCognitive abilitiesA Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes
Arcego D, Buschdorf J, O'Toole N, Wang Z, Barth B, Pokhvisneva I, Rayan N, Patel S, de Mendonça Filho E, Lee P, Tan J, Koh M, Sim C, Parent C, de Lima R, Clappison A, O'Donnell K, Dalmaz C, Arloth J, Provençal N, Binder E, Diorio J, Silveira P, Meaney M. A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes. Biological Psychiatry 2023, 95: 48-61. PMID: 37406925, DOI: 10.1016/j.biopsych.2023.06.028.Peer-Reviewed Original ResearchConceptsHippocampal dentate gyrusDentate gyrusPsychiatric disordersHuman hippocampal cellsBrain gray matter densityEarly adversitySingle nucleotide polymorphismsMultiple psychiatric conditionsEarly life adversityGray matter densityAdult female macaquesMental health outcomesTranscriptional activityGlucocorticoid exposureNucleotide polymorphismsLater psychosisStress mediatorsHippocampal cellsPsychotic disordersAnimal modelsHealth outcomesPsychiatric conditionsSignificant associationFemale macaquesMental health
2018
DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylome