2021
Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife
Shenk CE, Felt JM, Ram N, O'Donnell KJ, Sliwinski MJ, Pokhvisneva I, Benson L, Meaney MJ, Putnam FW, Noll JG. Cortisol trajectories measured prospectively across thirty years of female development following exposure to childhood sexual abuse: Moderation by epigenetic age acceleration at midlife. Psychoneuroendocrinology 2021, 136: 105606. PMID: 34896740, PMCID: PMC8724404, DOI: 10.1016/j.psyneuen.2021.105606.Peer-Reviewed Original ResearchConceptsEarly life adversityEpigenetic age accelerationChildhood sexual abuseCortisol trajectoriesLife adversityAge accelerationCortisol concentrationsBiological embedding modelProspective cohort studyPeak cortisol levelsHPA axis activitySubstantiated childhood sexual abuseEarly ageCohort studyAdulthood healthHPA axisAdrenal axisCortisol secretionCsA exposureCortisol levelsPotential indicationsSexual abuseMultiple biological systemsSubsequent occasionsBiological embedding
2010
Anxiety, depression and saliva cortisol in women with a medical disorder during pregnancy
King NM, Chambers J, O’Donnell K, Jayaweera SR, Williamson C, Glover VA. Anxiety, depression and saliva cortisol in women with a medical disorder during pregnancy. Archives Of Women's Mental Health 2010, 13: 339-345. PMID: 20101421, DOI: 10.1007/s00737-009-0139-5.Peer-Reviewed Original ResearchConceptsMedical disordersSaliva cortisolDiurnal saliva samplesAdverse pregnancy outcomesHigher EPDS scoresSubgroup of womenExtra psychological supportSelf-rating questionnaireVs. 35.2Antenatal womenHyperemesis gravidarumPregnancy outcomesEPDS scoresPregnant womenVs. 5.9Neurodevelopmental problemsCortisol levelsHealth professionalsPregnancySaliva samplesDisorder groupElevated levelsPsychological supportWomenDisorders
2009
Prenatal stress and the programming of the HPA axis
Glover V, O’Connor T, O’Donnell K. Prenatal stress and the programming of the HPA axis. Neuroscience & Biobehavioral Reviews 2009, 35: 17-22. PMID: 19914282, DOI: 10.1016/j.neubiorev.2009.11.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHPA axisPrenatal stressLong-term effectsIndependent prospective studiesHPA axis responseBasal cortisol levelsProspective studyAxis responseAnimal studiesCognitive alterationsCortisol responseCortisol levelsCognitive outcomesOutcomesRecent studiesGenetic strainsChildrenLittle evidenceOffspringGestationStudy