2024
Associations between Social Adversity and Biomarkers of Inflammation, Stress, and Aging in Children
Pantell M, Silveira P, de Mendonça Filho E, Wing H, Brown E, Keeton V, Pokhvisneva I, O’Donnell K, Neuhaus J, Hessler D, Meaney M, Adler N, Gottlieb L. Associations between Social Adversity and Biomarkers of Inflammation, Stress, and Aging in Children. Pediatric Research 2024, 95: 1553-1563. PMID: 38233512, PMCID: PMC11126389, DOI: 10.1038/s41390-023-02992-6.Peer-Reviewed Original ResearchSocial adversityChildhood social adversityBiomarkers of inflammationEpigenetic ageSocial risk factorsChildren aged 0ResultsOur final sampleCytokine clusterCumulative adversityFinal sampleSocial predictorsPediatric clinicAged 0Logistic regressionNeuroendocrine functionBiomarkers of stressRisk factorsImpactOur studySocial factorsU-shaped distributionAdversityAssociationBiomarker samplingChildhoodChildren
2021
Internalizing symptoms associate with the pace of epigenetic aging in childhood
Tollenaar MS, Beijers R, Garg E, Nguyen TTT, Lin DTS, MacIsaac JL, Shalev I, Kobor MS, Meaney MJ, O'Donnell KJ, de Weerth C. Internalizing symptoms associate with the pace of epigenetic aging in childhood. Biological Psychology 2021, 159: 108021. PMID: 33460784, DOI: 10.1016/j.biopsycho.2021.108021.Peer-Reviewed Original ResearchConceptsAdvanced biological agingChildhood psychiatric symptomsAge 6Longitudinal cohort studyInternalizing symptomsBiological agingChild mental healthCohort studyBuccal epithelial cellsPsychiatric symptomsSymptomsMental healthEpithelial cellsInternalizing disordersStatistical significanceAge 2.5Highest EAAExternalizing symptomsChildhoodEpigenetic agingHorvath clockGenome-wide DNA methylationEAA