2012
Autoantibodies Produced at the Site of Tissue Damage Provide Evidence of Humoral Autoimmunity in Inclusion Body Myositis
Ray A, Amato AA, Bradshaw EM, Felice KJ, DiCapua DB, Goldstein JM, Lundberg IE, Nowak RJ, Ploegh HL, Spooner E, Wu Q, Willis SN, O’Connor K. Autoantibodies Produced at the Site of Tissue Damage Provide Evidence of Humoral Autoimmunity in Inclusion Body Myositis. PLOS ONE 2012, 7: e46709. PMID: 23071619, PMCID: PMC3465259, DOI: 10.1371/journal.pone.0046709.Peer-Reviewed Original ResearchConceptsInclusion body myositisHumoral immune responseImmune responsePlasma cellsTissue damageBody myositisAntibody-secreting plasma cellsCell linesSingle plasma cellsMajor intermediate filament proteinMuscle tissueIBM patientsHumoral autoimmunityInflammatory myopathiesHuman-derived cell linesIBM muscleMuscle tissue sectionsMuscle tissue homogenatesMuscle diseaseTissue homogenatesTissue sectionsIntermediate filament proteinsMyositisAutoantibodiesDisease
2009
Epstein–Barr virus infection is not a characteristic feature of multiple sclerosis brain
Willis SN, Stadelmann C, Rodig SJ, Caron T, Gattenloehner S, Mallozzi SS, Roughan JE, Almendinger SE, Blewett MM, Brück W, Hafler DA, O’Connor K. Epstein–Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain 2009, 132: 3318-3328. PMID: 19638446, PMCID: PMC2792367, DOI: 10.1093/brain/awp200.Peer-Reviewed Original ResearchConceptsMultiple sclerosis brainEpstein-Barr virus infectionEBV infectionWhite matter lesionsMultiple sclerosisCentral nervous systemMatter lesionsVirus infectionSecond cohortEBV infected cellsB cell infiltrationB cell aggregatesInflammatory demyelinating diseaseB-cell infiltratesReal-time polymerase chain reaction methodologyCNS immunopathologyCNS lymphomaDemyelinating diseaseCell infiltrateSitu hybridizationCell infiltrationLarge cohortBrain pathologyNervous systemPolymerase chain reaction methodology