PET-Based Quantification of Baseline Metabolic Tumor Burden Improves Risk Stratification in High-Risk Hodgkin Lymphoma: A Children's Oncology Group Study
Milgrom S, Kim J, Hoppe B, Pei Q, Wu Y, Lo A, Kessel S, McCarten K, Roberts K, Hodgson D, Schwartz C, Friedman D, Kelly K, Cho S. PET-Based Quantification of Baseline Metabolic Tumor Burden Improves Risk Stratification in High-Risk Hodgkin Lymphoma: A Children's Oncology Group Study. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: s79-s80. DOI: 10.1016/j.ijrobp.2021.07.192.Peer-Reviewed Original ResearchRapid early respondersSlow early respondersMetabolic tumor volumeTotal lesion glycolysisBaseline metabolic tumor burdenHigh-risk Hodgkin lymphomaBaseline tumor burdenMetabolic tumor burdenTumor burdenIntensive therapyHodgkin's lymphomaPET scansEarly respondersCutoff valueEvent-free survival rateChildren's Oncology Group studyPositron emission tomography scanMaximum standardized uptake valueCycles of chemotherapyInitial disease burdenNodular sclerosis histologyResponse-adapted approachBaseline PET scanKaplan-Meier analysisAge 15.5 years