2022
North Asian population relationships in a global context
Kidd KK, Evsanaa B, Togtokh A, Brissenden JE, Roscoe JM, Dogan M, Neophytou PI, Gurkan C, Bulbul O, Cherni L, Speed WC, Murtha M, Kidd JR, Pakstis AJ. North Asian population relationships in a global context. Scientific Reports 2022, 12: 7214. PMID: 35508562, PMCID: PMC9068624, DOI: 10.1038/s41598-022-10706-x.Peer-Reviewed Original ResearchConceptsPopulation genetic studiesPhylogenetic tree analysisAutosomal variationSex chromosomesGenetic variationMost populationsGenetic studiesExtensive variationPopulation relationshipsGenome ConsortiumK projectNorth AsiaRefinement of analysisAsian ethnic groupsGlobal contextAutosomesTree analysisChromosomesAsia populationEthnic groupsMitochondriaPopulationMicrohaplotypesSmall subsetNative Americans
2021
Genetic relationships of Southwest Asian and Mediterranean populations
Kidd KK, Bulbul O, Gurkan C, Dogan M, Dogan S, Neophytou PI, Cherni L, Gurwitz D, Speed WC, Murtha M, Kidd JR, Pakstis AJ. Genetic relationships of Southwest Asian and Mediterranean populations. Forensic Science International Genetics 2021, 53: 102528. PMID: 34020230, DOI: 10.1016/j.fsigen.2021.102528.Peer-Reviewed Original ResearchGenetic diversity of the North African population revealed by the typing of SNPs in the DRD2/ANKK1 genomic region
Mestiri S, Boussetta S, Pakstis AJ, Elkamel S, Elgaaied ABA, Kidd KK, Cherni L. Genetic diversity of the North African population revealed by the typing of SNPs in the DRD2/ANKK1 genomic region. Gene 2021, 777: 145466. PMID: 33524518, DOI: 10.1016/j.gene.2021.145466.Peer-Reviewed Original ResearchMeSH KeywordsAdultAfrica, NorthernAllelesBlack PeopleEthnicityFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenomicsGenotypeGenotyping TechniquesHaplotypesHeterozygoteHuman MigrationHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideProtein Serine-Threonine KinasesReceptors, Dopamine D2ConceptsNorth African populationsGenetic diversitySingle nucleotide polymorphismsGenetic structureAncestral gene poolPeculiar genetic structureLowest average heterozygosityNorth African onesAfrican populationsHigh linkage disequilibriumGenetic driftGenomic regionsAverage heterozygosityGene poolSame locusLinkage disequilibriumDisequilibrium analysisGenetic componentGenesNucleotide polymorphismsLociReceptor geneDiversityHuman populationEuropean populations
2020
Validation of novel forensic DNA markers using multiplex microhaplotype sequencing
Gandotra N, Speed WC, Qin W, Tang Y, Pakstis AJ, Kidd KK, Scharfe C. Validation of novel forensic DNA markers using multiplex microhaplotype sequencing. Forensic Science International Genetics 2020, 47: 102275. PMID: 32305739, PMCID: PMC10131188, DOI: 10.1016/j.fsigen.2020.102275.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsMH lociMultiplex sequencingNovel single nucleotide polymorphismsSmall DNA amountsSingle MiSeq runMultiple single nucleotide polymorphismsHigher effective numberBiogeographic variationDNA markersGenomic sequencesNovel lociGenome ProjectDNA amountMiSeq runDifferent world populationsNucleotide polymorphismsLociSequencingMicrohaplotypesEffective numberDiverse range
2019
Genetic relationships of European, Mediterranean, and SW Asian populations using a panel of 55 AISNPs
Pakstis AJ, Gurkan C, Dogan M, Balkaya HE, Dogan S, Neophytou PI, Cherni L, Boussetta S, Khodjet-El-Khil H, Ben Ammar ElGaaied A, Salvo NM, Janssen K, Olsen GH, Hadi S, Almohammed EK, Pereira V, Truelsen DM, Bulbul O, Soundararajan U, Rajeevan H, Kidd JR, Kidd KK. Genetic relationships of European, Mediterranean, and SW Asian populations using a panel of 55 AISNPs. European Journal Of Human Genetics 2019, 27: 1885-1893. PMID: 31285530, PMCID: PMC6871633, DOI: 10.1038/s41431-019-0466-6.Peer-Reviewed Original ResearchGenetic history of the population of Crete
Drineas P, Tsetsos F, Plantinga A, Lazaridis I, Yannaki E, Razou A, Kanaki K, Michalodimitrakis M, Perez‐Jimenez F, De Silvestro G, Renda MC, Stamatoyannopoulos JA, Kidd KK, Browning BL, Paschou P, Stamatoyannopoulos G. Genetic history of the population of Crete. Annals Of Human Genetics 2019, 83: 373-388. PMID: 31192450, PMCID: PMC6851683, DOI: 10.1111/ahg.12328.Peer-Reviewed Original ResearchConceptsHistorical recordsCretan populationMedieval historyMedieval periodArab occupationMultiple warsSmall genetic contributionContemporary recordsMiddle AgesGenetic historyIsland of CreteEastern EuropeansPopulation of CreteHistoriansCreteVenetiansOccupationCretanBiased interpretationLocal populationHistoryGenetic perspectiveRecordsIslandsConquerors
2017
Increasing the reference populations for the 55 AISNP panel: the need and benefits
Pakstis AJ, Kang L, Liu L, Zhang Z, Jin T, Grigorenko EL, Wendt FR, Budowle B, Hadi S, Al Qahtani MS, Morling N, Mogensen HS, Themudo GE, Soundararajan U, Rajeevan H, Kidd JR, Kidd KK. Increasing the reference populations for the 55 AISNP panel: the need and benefits. International Journal Of Legal Medicine 2017, 131: 913-917. PMID: 28070634, PMCID: PMC5491587, DOI: 10.1007/s00414-016-1524-z.Peer-Reviewed Original Research
2014
Application of six IrisPlex SNPs and comparison of two eye color prediction systems in diverse Eurasia populations
Yun L, Gu Y, Rajeevan H, Kidd KK. Application of six IrisPlex SNPs and comparison of two eye color prediction systems in diverse Eurasia populations. International Journal Of Legal Medicine 2014, 128: 447-453. PMID: 24395150, DOI: 10.1007/s00414-013-0953-1.Peer-Reviewed Original Research
2011
High altitude adaptation in Daghestani populations from the Caucasus
Pagani L, Ayub Q, MacArthur DG, Xue Y, Baillie JK, Chen Y, Kozarewa I, Turner DJ, Tofanelli S, Bulayeva K, Kidd K, Paoli G, Tyler-Smith C. High altitude adaptation in Daghestani populations from the Caucasus. Human Genetics 2011, 131: 423-433. PMID: 21904933, PMCID: PMC3312735, DOI: 10.1007/s00439-011-1084-8.Peer-Reviewed Original ResearchSelecting SNPs to Identify Ancestry
Sampson JN, Kidd KK, Kidd JR, Zhao H. Selecting SNPs to Identify Ancestry. Annals Of Human Genetics 2011, 75: 539-553. PMID: 21668909, PMCID: PMC3141729, DOI: 10.1111/j.1469-1809.2011.00656.x.Peer-Reviewed Original ResearchHunter-gatherer genomic diversity suggests a southern African origin for modern humans
Henn BM, Gignoux CR, Jobin M, Granka JM, Macpherson JM, Kidd JM, Rodríguez-Botigué L, Ramachandran S, Hon L, Brisbin A, Lin AA, Underhill PA, Comas D, Kidd KK, Norman PJ, Parham P, Bustamante CD, Mountain JL, Feldman MW. Hunter-gatherer genomic diversity suggests a southern African origin for modern humans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 5154-5162. PMID: 21383195, PMCID: PMC3069156, DOI: 10.1073/pnas.1017511108.Peer-Reviewed Original ResearchConceptsHunter-gatherer populationsAfrican hunter-gatherer populationsModern humansGenome-wide linkage disequilibriumModern human populationsSex-biased migrationSevere population bottleneckLinkage disequilibriumSouthern African originHuman prehistoryAfrican populationsComplex historyPopulation differentiationPopulation bottlenecksGenetic diversityGenomic diversityEastern AfricaGenetic variationAfrican originPopulation todaySouthern AfricaGeographic patternsContinent of originAfricaSouth Africa
2010
A variant of the endothelial nitric oxide synthase gene (NOS3) associated with AMS susceptibility is less common in the Quechua, a high altitude Native population.
Wang P, Ha AY, Kidd KK, Koehle MS, Rupert JL. A variant of the endothelial nitric oxide synthase gene (NOS3) associated with AMS susceptibility is less common in the Quechua, a high altitude Native population. High Altitude Medicine & Biology 2010, 11: 27-30. PMID: 20367485, DOI: 10.1089/ham.2009.1054.Peer-Reviewed Original ResearchConceptsHigh-altitude pulmonary edemaEndothelial nitric oxide synthaseAcute mountain sicknessNitric oxideG alleleEndothelial nitric oxide synthase geneAltitude-related illnessesG894T polymorphismNitric oxide synthase geneNitric oxide synthaseAltitude pulmonary edemaOxide synthase geneNOS3 genotypesPulmonary edemaOxide synthaseVascular enzymeMountain sicknessT polymorphismBlood flowAltitude toleranceNOS3AMS susceptibilityHypoxic environmentHigh-altitude native populationsEnvironmental hypoxia
2009
Genetic Landscape of Eurasia and “Admixture” in Uyghurs
Li H, Cho K, Kidd JR, Kidd KK. Genetic Landscape of Eurasia and “Admixture” in Uyghurs. American Journal Of Human Genetics 2009, 85: 934-937. PMID: 20004770, PMCID: PMC2790568, DOI: 10.1016/j.ajhg.2009.10.024.Peer-Reviewed Original Research
1997
Population genetics of a functional variant of the dopamine β‐hydroxylase gene (DBH)
Cubells J, Kobayashi K, Nagatsu T, Kidd K, Kidd J, Calafell F, Kranzler H, Ichinose H, Gelernter J. Population genetics of a functional variant of the dopamine β‐hydroxylase gene (DBH). American Journal Of Medical Genetics 1997, 74: 374-379. PMID: 9259372, DOI: 10.1002/(sici)1096-8628(19970725)74:4<374::aid-ajmg7>3.0.co;2-p.Peer-Reviewed Original Research
1996
DRD2 Haplotypes Containing the TaqI A1 Allele: Implications for Alcoholism Research
Kidd K, Pakstis A, Castiglione C, Kidd J, Speed W, Goldman D, Knowler W, Lu R, Bonne‐Tamir B. DRD2 Haplotypes Containing the TaqI A1 Allele: Implications for Alcoholism Research. Alcohol Clinical And Experimental Research 1996, 20: 697-705. PMID: 8800387, DOI: 10.1111/j.1530-0277.1996.tb01674.x.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAllelesAnimalsChromosome MappingDeoxyribonucleases, Type II Site-SpecificEthnicityGene FrequencyGenetics, PopulationHaplotypesHumansPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Restriction Fragment LengthReceptors, Dopamine D2Repetitive Sequences, Nucleic AcidResearchConceptsGenetic variationAssociation studiesUnrelated control samplesDopamine D2 receptor locusDiversity of haplotypesShort tandem repeat polymorphismsDRD2 locusEvolutionary historyRestriction fragment length polymorphismPopulation geneticsPhylogenetic originFragment length polymorphismAncestral originReceptor locusHomologous regionsIntron 2LociAllelic systemHigher primatesHaplotypesTandem repeat polymorphismAllelesConsiderable diversityDRD2 haplotypesPolymorphismNo association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct taiwanese populations
Lu R, Ko H, Chang F, Castiglione C, Schoolfield G, Pakstis A, Kidd J, Kidd K. No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct taiwanese populations. Biological Psychiatry 1996, 39: 419-429. PMID: 8679787, DOI: 10.1016/0006-3223(95)00182-4.Peer-Reviewed Original Research
1995
Linkage of congenital, recessive deafness (DFNB4) to chromosome 7q31 and evidence for genetic heterogeneity in the Middle Eastern Druze population
Baldwin C, Weiss S, Farrer L, De Stefano A, Adair R, Franklyn B, Kidd K, Korostishevsky M, Bonné-Tamir B. Linkage of congenital, recessive deafness (DFNB4) to chromosome 7q31 and evidence for genetic heterogeneity in the Middle Eastern Druze population. Human Molecular Genetics 1995, 4: 1637-1642. PMID: 8541853, DOI: 10.1093/hmg/4.9.1637.Peer-Reviewed Original ResearchConceptsHuman chromosome 7q31Genetic linkage analysisNon-syndromic deafnessChromosomal locationGene locationNon-syndromic formsRecessive non-syndromic deafnessLinkage analysisChromosome 7q31Nonallelic mutationsGenetic isolateLarge familyLOD scoreGenetic heterogeneityGenetic causeRecessive deafnessGenesRecognizable phenotypeFirst evidenceDruze familyFamilyAffected individualsSpecific patternsMutationsPhenotype
1993
A hypervariable segment in the human dopamine receptor D4 (DRD4) gene
Lichter J, Barr C, Kennedy J, Van Tol H, Kidd K, Livak K. A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Human Molecular Genetics 1993, 2: 767-773. PMID: 8353495, DOI: 10.1093/hmg/2.6.767.Peer-Reviewed Original ResearchConceptsHuman dopamine receptor D4 geneAmino acid sequenceThird cytoplasmic loopNumber of repeatsPutative third cytoplasmic loopFunctional proteinsCytoplasmic loopAcid sequenceRepeat regionDifferent repeatsHypervariable segmentDifferent haplotypesRepeatsDopamine receptor D4 geneUnrelated chromosomesNovel polymorphismsD4 geneGenesProteinHuman dopamine D4 receptorPolymorphic variantsSequencePolymorphismChromosomesReceptors
1991
Status of the search for a major genetic locus for affective disorder in the Old Order Amish
Pakstis A, Kidd J, Castiglione C, Kidd K. Status of the search for a major genetic locus for affective disorder in the Old Order Amish. Human Genetics 1991, 87: 475-483. PMID: 1879834, DOI: 10.1007/bf00197172.Peer-Reviewed Original Research
1990
Genetic and physical mapping and population studies of a fibronectin receptor β-subunit-like sequence on human chromosome 19
Giuffra L, Lichter P, Wu J, Kennedy J, Pakstis A, Rogers J, Kidd J, Harley H, Jenkins T, Ward D, Kidd K. Genetic and physical mapping and population studies of a fibronectin receptor β-subunit-like sequence on human chromosome 19. Genomics 1990, 8: 340-346. PMID: 1979054, DOI: 10.1016/0888-7543(90)90291-2.Peer-Reviewed Original ResearchConceptsChromosome 19Human chromosome 19Chromosome 10 (PTEN) geneHuman fibronectin receptorChromosome 10 markersInsertion of partDifferent polymorphic lociPericentromeric regionCDNA clonesPhysical mappingPolymorphic lociChromosome 10Dominant polymorphismBeta subunitLinkage analysisShort armFibronectin receptorSitu hybridizationCodominant systemsGenesSecond polymorphismReceptor βPolymorphismCDNALoci