2010
A Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma
Godshalk SE, Paranjape T, Nallur S, Speed W, Chan E, Molinaro AM, Bacchiocchi A, Hoyt K, Tworkoski K, Stern DF, Sznol M, Ariyan S, Lazova R, Halaban R, Kidd KK, Weidhaas JB, Slack FJ. A Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma. Oncogene 2010, 30: 1542-1550. PMID: 21119596, PMCID: PMC3069149, DOI: 10.1038/onc.2010.536.Peer-Reviewed Original ResearchConceptsMessenger RNAsComplementary sitesNovel genetic markersKIT oncogeneTarget genesRegulatory relationshipsUntranslated regionGenetic markersHeritable riskFunctional variantsGenetic variantsOncogeneMultifaceted roleProtein levelsProtein expressionVariant resultsComplementary sequencesReporter dataUTRMelanoma pathogenesisMiR-221KIT variantsSeed regionExpressionVariants
1991
Rearrangement of the retinoic acid receptor gene in acute promyelocytic leukemia.
Chang K, Trujillo J, Ogura T, Castiglione C, Kidd K, Zhao S, Freireich E, Stass S. Rearrangement of the retinoic acid receptor gene in acute promyelocytic leukemia. Leukemia 1991, 5: 200-4. PMID: 1849600.Peer-Reviewed Original ResearchConceptsAcute promyelocytic leukemiaRAR alpha geneAPL patientsPromyelocytic leukemiaAPL patient samplesRetinoic acid receptor alpha geneAcid receptor alpha geneRAR-alpha mRNAReceptor alpha geneRetinoic acid receptor genesAcute leukemiaPatientsLeukemic samplesPatient samplesLeukemiaReceptor geneNorthern blot analysisBlot analysisMRNA