2021
Forensic Ancestry Inference: Data Requirements, Analysis Methods, and Interpretation of Results
Bulbul O, Kidd K. Forensic Ancestry Inference: Data Requirements, Analysis Methods, and Interpretation of Results. 2021, 225-240. DOI: 10.1201/9781003043027-12.Peer-Reviewed Original ResearchStandard DNA markersSingle nucleotide polymorphismsInformative single nucleotide polymorphismsAncestry informative single nucleotide polymorphismsDNA markersShort tandem repeatsTandem repeatsBiogeographic ancestryDNA profilesCrime scene DNANucleotide polymorphismsParallel sequencing technologiesAncestry informative SNPsShort tandem repeat polymorphismsDifferent populationsSequencing technologiesFuture forensic studiesMost populationsForensic geneticsAncestry assignmentTandem repeat polymorphismDNA samplesRepeatsAncestryDNA
2013
Worldwide Population Variation and Haplotype Analysis at the Serotonin Transporter Gene SLC6A4 and Implications for Association Studies
Murdoch JD, Speed WC, Pakstis AJ, Heffelfinger CE, Kidd KK. Worldwide Population Variation and Haplotype Analysis at the Serotonin Transporter Gene SLC6A4 and Implications for Association Studies. Biological Psychiatry 2013, 74: 879-889. PMID: 23510579, DOI: 10.1016/j.biopsych.2013.02.006.Peer-Reviewed Original ResearchConceptsVariable number tandem repeatSingle nucleotide polymorphismsFunctional single nucleotide polymorphismsPromoter variable number tandem repeatRestricted distributionAssociation studiesRare allelesPutative functional single nucleotide polymorphismsPossible functional variationPopulation-specific distributionWide geographic distributionAlleles of interestHealth-related phenotypesAdditional single nucleotide polymorphismsPopulation variationSerotonin transporter gene SLC6A4Transporter geneFunctional variationTandem repeatsNumber tandem repeatSNP rs25531Extent of variationGeographic distributionNucleotide polymorphismsHaplotype background
2008
Global patterns of variation in allele and haplotype frequencies and linkage disequilibrium across the CYP2E1 gene
Lee M, Mukherjee N, Pakstis A, Khaliq S, Mohyuddin A, Mehdi S, Speed W, Kidd J, Kidd K. Global patterns of variation in allele and haplotype frequencies and linkage disequilibrium across the CYP2E1 gene. The Pharmacogenomics Journal 2008, 8: 349-356. PMID: 18663376, PMCID: PMC2782390, DOI: 10.1038/tpj.2008.9.Peer-Reviewed Original ResearchConceptsGenetic variationGene expressionAssociation studiesFamily of enzymesDifferent human populationsHaplotype variationHuman population samplesMajor geographical regionsTandem repeatsPolymorphism haplotypesGenesMultiple populationsHaplotypesSusceptibility mutationsGlobal patternsHuman populationAdditional polymorphismsHaplotype frequenciesCentral roleDifferent populationsDiverse patternsEndogenous compoundsDisequilibriumLD dataPolymorphism
2004
The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus
Wang E, Ding Y, Flodman P, Kidd J, Kidd K, Grady D, Ryder O, Spence M, Swanson J, Moyzis R. The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus. American Journal Of Human Genetics 2004, 74: 931-944. PMID: 15077199, PMCID: PMC1181986, DOI: 10.1086/420854.Peer-Reviewed Original ResearchConceptsLittle linkage disequilibriumHuman dopamine receptor D4 genePolymorphic sitesDNA sequence organizationMost polymorphic sitesPatterns of recombinationObserved LD patternRare mutational eventsDRD4 locusGenetic architectureHaplotype diversityPositive selectionMore polymorphismsSequence organizationGene locusTandem repeatsMutational eventsLD patternsLinkage disequilibriumDopamine receptor D4 geneLociPhysiological differencesSame alleleReceptor variantsAlleles
2000
Evolution of exon 1 of the dopamine D4 receptor (DRD4) gene in primates
Seaman M, Chang F, Deinard A, Quiñones A, Kidd K. Evolution of exon 1 of the dopamine D4 receptor (DRD4) gene in primates. Journal Of Experimental Zoology 2000, 288: 32-38. PMID: 10750051, DOI: 10.1002/(sici)1097-010x(20000415)288:1<32::aid-jez4>3.0.co;2-g.Peer-Reviewed Original ResearchConceptsHigh conservationOld World monkeysWorld monkeysTandem repeatsPrimate speciesExon 1Amino acid sequenceReceptor geneGreat apesRelaxed selectionEvolutionary historyD4 receptor geneHomologous exonsInterspecific differencesNew World monkeysDopamine D4 receptor geneAcid sequenceSelective pressureFirst exonTandem duplicationExonsExon 3SpeciesGenesRepeats
1996
The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus
Chang F, Kidd J, Livak K, Pakstis A, Kidd K. The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus. Human Genetics 1996, 98: 91-101. PMID: 8682515, DOI: 10.1007/s004390050166.Peer-Reviewed Original ResearchConceptsImperfect tandem repeatsAllele frequenciesDifferent populationsActual allele frequenciesDopamine D4 receptor locusSelective forcesEvolutionary significanceWorld-wide distributionAssociation studiesReceptor locusTandem repeatsThird exonBase pairsAmino acidsFunctional relevanceRepeatsReceptor geneAllelesLociModern humansPolymorphismD4 receptor geneDopamine D4 receptor geneRepeat polymorphismExons