1986
Understanding the Clinical Heterogeneity of Major Depression Using Family Data
Weissman M, Merikangas K, Priya W, Kidd K, Prusoff B, Leckman J, Pauls D. Understanding the Clinical Heterogeneity of Major Depression Using Family Data. JAMA Psychiatry 1986, 43: 430-434. PMID: 3964021, DOI: 10.1001/archpsyc.1986.01800050028003.Peer-Reviewed Original ResearchConceptsMajor depressionSymptom patternsHistory of hospitalizationClinical presentationClinical severityRecurrent depressionSecondary alcoholismClinical heterogeneitySuicidal ideationAnxiety disordersDepressionFamilial aggregationEarly ageDisordersCombination of criteriaAgeSubgroupsRiskOnsetPutative subgroupsHospitalization
1985
Drug response as a predictor of transmission of non-bipolar major depression within families
Prusoff B, Weissman M, Merikangas K, Leckman J, Kidd K. Drug response as a predictor of transmission of non-bipolar major depression within families. Journal Of Affective Disorders 1985, 8: 171-176. PMID: 3157727, DOI: 10.1016/0165-0327(85)90041-2.Peer-Reviewed Original ResearchConceptsNon-bipolar major depressionMajor depressionAffective illnessFirst-degree relativesTermination of treatmentRelatives of probandsClinical responsePharmacological therapyPoor responseClinical trialsSomatic treatmentsDistinct subtypesPredictors of transmissionFirst weekDrug responseFamilial aggregationRapid improvementDepressionProbandsHigh rateIllnessSubtypesTreatmentResponseTherapy