2018
Response to Letter to the Editor concerning manuscript, “Blood pressure variability predicts adverse events and cardiovascular outcomes in sprint”
Mezue K, Goyal A, Pressman G, Matthew R, Horrow J, Rangaswami J. Response to Letter to the Editor concerning manuscript, “Blood pressure variability predicts adverse events and cardiovascular outcomes in sprint”. Journal Of Clinical Hypertension 2018, 20: 1646-1647. PMID: 30328256, PMCID: PMC8030952, DOI: 10.1111/jch.13400.Peer-Reviewed Original ResearchMeSH KeywordsAntihypertensive AgentsBlood PressureBlood Pressure DeterminationCardiovascular SystemHumansHypertensionBlood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT
Mezue K, Goyal A, Pressman G, Matthew R, Horrow J, Rangaswami J. Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT. Journal Of Clinical Hypertension 2018, 20: 1247-1252. PMID: 29984884, PMCID: PMC8031192, DOI: 10.1111/jch.13346.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAntihypertensive AgentsBlood PressureBlood Pressure DeterminationCardiovascular DiseasesFemaleHumansHypertensionMaleRegression AnalysisRisk FactorsConceptsAdverse eventsDiastolic BPCardiovascular outcomesDiastolic BP-CVSystolic BPAntihypertensive therapyTreatment armsRate of treatment-related adverse eventsPrimary outcomeTreatment-related adverse eventsBlood pressureEffects of antihypertensive therapyCox proportional hazards regressionAcute kidney injuryCompare treatment armsPredictors of outcomeVisit-to-visitStudent's t-testTarget systolic BPProportional hazards regressionBlood pressure variabilityLevels of BPSPRINT dataVisit-to-visit DBP variabilityIndependent predictors
2017
Clinical hypertension: Blood pressure variability
Malik E, Abdulhadi B, Mezue K, Lerma E, Rangaswami J. Clinical hypertension: Blood pressure variability. Disease-a-Month 2017, 64: 5-13. PMID: 28939280, DOI: 10.1016/j.disamonth.2017.08.003.Peer-Reviewed Original ResearchBlood Pressure Variability Predicts Adverse Events and Cardiovascular Outcomes in Chronic Kidney Disease: A Post-Hoc Analysis of the SPRINT Trial
Mezue K, Goyal A, Pressman G, Horrow J, Rangaswami J. Blood Pressure Variability Predicts Adverse Events and Cardiovascular Outcomes in Chronic Kidney Disease: A Post-Hoc Analysis of the SPRINT Trial. American Journal Of Hypertension 2017, 31: 48-52. PMID: 28985328, DOI: 10.1093/ajh/hpx128.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseAcute kidney injuryDiastolic blood pressureDBP CVVisit-to-visitCardiovascular outcomesBlood pressure variabilityAdverse eventsPrimary outcomeKidney diseaseBlood pressureAssociated with adverse cardiovascular outcomesVisit-to-visit blood pressure variabilityCox proportional hazards regressionTarget systolic blood pressureAdverse cardiovascular outcomesPressure variabilityProportional hazards regressionSystolic blood pressurePredicting adverse eventsPost hoc analysisVisit-to-visit DBP variabilityAntihypertensive therapyIndependent predictorsKidney injuryVisit‐to‐visit systolic blood pressure variability predicts treatment‐related adverse event of hyponatremia in SPRINT
Goyal A, Mezue K, Rangaswami J. Visit‐to‐visit systolic blood pressure variability predicts treatment‐related adverse event of hyponatremia in SPRINT. Cardiovascular Therapeutics 2017, 35 PMID: 28544636, DOI: 10.1111/1755-5922.12274.Peer-Reviewed Original ResearchConceptsVisit-to-visit systolic blood pressure variabilitySystolic blood pressureSystolic blood pressure variabilityTarget blood pressureBlood pressureBlood pressure variabilitySPRINT trialAdverse eventsSystolic blood pressure <Occurrence of hyponatremiaCox proportional hazards regressionRisk of hyponatremiaBlood pressure <Coefficient of variation of systolic blood pressureProportional hazards regressionStandard treatment groupCardiovascular risk factorsPressure variabilityOverall cohortTreatment armsTreatment subgroupsHazards regressionInclusion criteriaCoefficient of variationHyponatremia
2015
Role of Vasodilator Testing in Pulmonary Hypertension
Sharma A, Obiagwu C, Mezue K, Garg A, Mukherjee D, Haythe J, Shetty V, Einstein A. Role of Vasodilator Testing in Pulmonary Hypertension. Progress In Cardiovascular Diseases 2015, 58: 425-433. PMID: 26434988, DOI: 10.1016/j.pcad.2015.09.006.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionCalcium channel blockersVasodilator testingPulmonary arteryIdiopathic pulmonary arterial hypertensionNormalization of pulmonary hemodynamicsAcute vasodilator testingRight heart catheterizationInhaled nitric oxideMean pulmonary arteryInhaled iloprostIntravenous epoprostenolHeart catheterizationPulmonary hypertensionVasoreactivity testingIntravenous adenosineArterial hypertensionChannel blockersPulmonary hemodynamicsNear normalizationStandard agentsPatientsNitric oxideHypertensionVasodilation