Blood Pressure Variability Predicts Adverse Events and Cardiovascular Outcomes in Chronic Kidney Disease: A Post-Hoc Analysis of the SPRINT Trial
Mezue K, Goyal A, Pressman G, Horrow J, Rangaswami J. Blood Pressure Variability Predicts Adverse Events and Cardiovascular Outcomes in Chronic Kidney Disease: A Post-Hoc Analysis of the SPRINT Trial. American Journal Of Hypertension 2017, 31: 48-52. PMID: 28985328, DOI: 10.1093/ajh/hpx128.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseAcute kidney injuryDiastolic blood pressureDBP CVVisit-to-visitCardiovascular outcomesBlood pressure variabilityAdverse eventsPrimary outcomeKidney diseaseBlood pressureAssociated with adverse cardiovascular outcomesVisit-to-visit blood pressure variabilityCox proportional hazards regressionTarget systolic blood pressureAdverse cardiovascular outcomesPressure variabilityProportional hazards regressionSystolic blood pressurePredicting adverse eventsPost hoc analysisVisit-to-visit DBP variabilityAntihypertensive therapyIndependent predictorsKidney injuryVisit‐to‐visit systolic blood pressure variability predicts treatment‐related adverse event of hyponatremia in SPRINT
Goyal A, Mezue K, Rangaswami J. Visit‐to‐visit systolic blood pressure variability predicts treatment‐related adverse event of hyponatremia in SPRINT. Cardiovascular Therapeutics 2017, 35 PMID: 28544636, DOI: 10.1111/1755-5922.12274.Peer-Reviewed Original ResearchConceptsVisit-to-visit systolic blood pressure variabilitySystolic blood pressureSystolic blood pressure variabilityTarget blood pressureBlood pressureBlood pressure variabilitySPRINT trialAdverse eventsSystolic blood pressure <Occurrence of hyponatremiaCox proportional hazards regressionRisk of hyponatremiaBlood pressure <Coefficient of variation of systolic blood pressureProportional hazards regressionStandard treatment groupCardiovascular risk factorsPressure variabilityOverall cohortTreatment armsTreatment subgroupsHazards regressionInclusion criteriaCoefficient of variationHyponatremia