2018
Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT
Mezue K, Goyal A, Pressman G, Matthew R, Horrow J, Rangaswami J. Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT. Journal Of Clinical Hypertension 2018, 20: 1247-1252. PMID: 29984884, PMCID: PMC8031192, DOI: 10.1111/jch.13346.Peer-Reviewed Original ResearchConceptsAdverse eventsDiastolic BPCardiovascular outcomesDiastolic BP-CVSystolic BPAntihypertensive therapyTreatment armsRate of treatment-related adverse eventsPrimary outcomeTreatment-related adverse eventsBlood pressureEffects of antihypertensive therapyCox proportional hazards regressionAcute kidney injuryCompare treatment armsPredictors of outcomeVisit-to-visitStudent's t-testTarget systolic BPProportional hazards regressionBlood pressure variabilityLevels of BPSPRINT dataVisit-to-visit DBP variabilityIndependent predictors
2017
Visit‐to‐visit systolic blood pressure variability predicts treatment‐related adverse event of hyponatremia in SPRINT
Goyal A, Mezue K, Rangaswami J. Visit‐to‐visit systolic blood pressure variability predicts treatment‐related adverse event of hyponatremia in SPRINT. Cardiovascular Therapeutics 2017, 35 PMID: 28544636, DOI: 10.1111/1755-5922.12274.Peer-Reviewed Original ResearchConceptsVisit-to-visit systolic blood pressure variabilitySystolic blood pressureSystolic blood pressure variabilityTarget blood pressureBlood pressureBlood pressure variabilitySPRINT trialAdverse eventsSystolic blood pressure <Occurrence of hyponatremiaCox proportional hazards regressionRisk of hyponatremiaBlood pressure <Coefficient of variation of systolic blood pressureProportional hazards regressionStandard treatment groupCardiovascular risk factorsPressure variabilityOverall cohortTreatment armsTreatment subgroupsHazards regressionInclusion criteriaCoefficient of variationHyponatremia