Efficacy and safety of chloroquine and hydroxychloroquine for treatment of COVID-19 patients-a systematic review and meta-analysis of randomized controlled trials.
Eze P, Mezue K, Nduka C, Obianyo I, Egbuche O. Efficacy and safety of chloroquine and hydroxychloroquine for treatment of COVID-19 patients-a systematic review and meta-analysis of randomized controlled trials. Am J Cardiovasc Dis 2021, 11: 93-107. PMID: 33815925, PMCID: PMC8012280.Peer-Reviewed Original ResearchRandomized clinical trialsStandard supportive therapyAdverse eventsSupportive therapyMeta-analysis of randomized controlled trialsPublished randomized clinical trialsMeta-analysisSevere adverse eventsSafety of CQSafety of chloroquineJoanna Briggs Institute DatabaseCochrane Collaboration assessment toolTreatment of COVID-19 patientsChinese Clinical Trial RegistryClinical Trials RegistryRandom-effects modelSub-group analysisRandomized controlled trialsCOVID-19 patientsRisk of biasMortality meta-analysisIn vivo studiesEfficacy outcomesInstitutional databaseMortality benefit