2021
Male sex, ostomy, infection, and intravenous fluids are associated with increased risk of postoperative ileus in elective colorectal surgery
Koch K, Hahn A, Hart A, Kahl A, Charlton M, Kapadia M, Hrabe J, Cromwell J, Hassan I, Gribovskaja-Rupp I. Male sex, ostomy, infection, and intravenous fluids are associated with increased risk of postoperative ileus in elective colorectal surgery. Surgery 2021, 170: 1325-1330. PMID: 34210525, DOI: 10.1016/j.surg.2021.05.035.Peer-Reviewed Original ResearchConceptsElective colorectal surgeryAcute kidney injuryEnhanced recovery protocolPostoperative ileusIntravenous fluidsRenal functionMale sexColorectal resectionKidney injuryColorectal surgeryIleorectal anastomosisHigh riskTertiary academic medical centerRecovery protocolElective colorectal resectionIntravenous fluid administrationIntravenous fluid volumeNasogastric tube insertionAcademic medical centerIntestinal reconstructionNasogastric decompressionRenal damageSecondary outcomesColorectal anastomosisPostoperative infection
2020
AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells
Gu VW, Cho E, Thompson DT, Cassady VC, Borcherding N, Koch KE, Wu VT, Lorenzen AW, van der Heide DM, White JR, Kulak MV, Williams T, Zhang W, Weigel RJ. AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells. Stem Cell Reports 2020, 16: 106-119. PMID: 33382976, PMCID: PMC7897584, DOI: 10.1016/j.stemcr.2020.12.002.Peer-Reviewed Original ResearchConceptsMammary stem cellsAP-2γMultipotent mammary stem cellsMammary gland ductal morphogenesisAP-2γ transcription factorMammary gland structureMammary gland developmentStem cellsMammary epithelial cellsAdult MaSCsBasal epitheliumDuctal outgrowthMammary developmentLuminal progenitorsConditional knockoutEpithelial cellsLuminal lineageMammary lineageDuctal morphogenesisGland developmentNumber of cellsRegenerative capacityGland structureExpression of genesCellsImpact of routine mismatch repair screening on genetic counseling and surgical management in colorectal cancer patients
Koch K, Goffredo P, Hrabe J, Gribovskaja-Rupp I, Snow A, Bellizzi A, Kapadia M. Impact of routine mismatch repair screening on genetic counseling and surgical management in colorectal cancer patients. The American Journal Of Surgery 2020, 222: 408-412. PMID: 33317812, DOI: 10.1016/j.amjsurg.2020.12.017.Peer-Reviewed Original ResearchConceptsExtended resectionGenetic counselingResection extentColorectal cancerLynch syndromeCRC specimensMMR deficiencySingle-institution retrospective reviewMMR-deficient patientsSurgical resection extentColorectal cancer patientsMLH1 promoter hypermethylationMismatch repair deficiencyLynch syndrome diagnosisMMR testingRetrospective reviewSegmental resectionSurgical managementCancer patientsLS patientsPatientsResectionSyndrome diagnosisRepair deficiencyFurther studiesA TFAP2C Gene Signature Is Predictive of Outcome in HER2-Positive Breast Cancer
Wu VT, Kiriazov B, Koch KE, Gu VW, Beck AC, Borcherding N, Li T, Addo P, Wehrspan ZJ, Zhang W, Braun TA, Brown BJ, Band V, Band H, Kulak MV, Weigel RJ. A TFAP2C Gene Signature Is Predictive of Outcome in HER2-Positive Breast Cancer. Molecular Cancer Research 2020, 18: 46-56. PMID: 31619506, PMCID: PMC6942205, DOI: 10.1158/1541-7786.mcr-19-0359.Peer-Reviewed Original ResearchConceptsBreast cancerGene signatureAP-2γHER2-positive breast cancerOutcomes of patientsExpression of estrogenSubset of patientsLuminal breast cancerSubset of HER2AP-2γ transcription factorBreast cancer subtypesPathway analysisPhysiologic effectsClinical relevanceCancer growthHER2Hormone responseCancer subtypesDifferent HER2CancerPatientsRetinoic acid pathwayCancer linesOutcomesCell lines