Impact of routine mismatch repair screening on genetic counseling and surgical management in colorectal cancer patients
Koch K, Goffredo P, Hrabe J, Gribovskaja-Rupp I, Snow A, Bellizzi A, Kapadia M. Impact of routine mismatch repair screening on genetic counseling and surgical management in colorectal cancer patients. The American Journal Of Surgery 2020, 222: 408-412. PMID: 33317812, DOI: 10.1016/j.amjsurg.2020.12.017.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBrain NeoplasmsColorectal NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisEarly Detection of CancerFemaleGenetic CounselingGenetic TestingHumansMaleMiddle AgedNeoplastic Syndromes, HereditaryRetrospective StudiesConceptsExtended resectionGenetic counselingResection extentColorectal cancerLynch syndromeCRC specimensMMR deficiencySingle-institution retrospective reviewMMR-deficient patientsSurgical resection extentColorectal cancer patientsMLH1 promoter hypermethylationMismatch repair deficiencyLynch syndrome diagnosisMMR testingRetrospective reviewSegmental resectionSurgical managementCancer patientsLS patientsPatientsResectionSyndrome diagnosisRepair deficiencyFurther studies