Kelsey Koch
Hospital ResidentDownloadHi-Res Photo
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Yale School of Medicine
330 Cedar St
New Haven, CT 06510
United States
About
Titles
Hospital Resident
Biography
Kelsey was born and raised in the Upper Midwest. She obtained her undergraduate degree at South Dakota School of Mines and Technology in the Black Hills, graduating Summa Cum Laude with a Bachelor of Science in Chemistry. She then attended medical school at the University of South Dakota, Sanford School of Medicine, graduating Magna Cum Laude. She completed her General Surgery residency at the University of Iowa and was honored to serve as the Chief Resident for her program in her final year.
In addition to clinical outcomes research, Kelsey completed fellowships in surgical education research and educational leadership during her dedicated research time while focusing on transcriptional mechanisms of cancer biology as a T32 fellow under the guidance of Ronald J. Weigel, MD, PhD, MBA. She chose to pursue a career in Cardiothoracic Surgery after having the privilege to care for surgical oncology patients during her residency training. She is interested in both surgical education research as well surgical education leadership and plans to practice in a setting that allows her to continue to research and educate while providing exceptional care for patients.
Education & Training
- Fellow
- Yale School Of Medicine (2025)
- Resident
- University of Iowa (2023)
- Chief Resident
- University of Iowa (2023)
- Research Fellow
- University of Iowa (2020)
- MD
- University of South Dakota, Sanford School of Medicine (2016)
- BS
- South Dakota School of Mines and Technology, Chemistry (2012)
Research
Overview
Medical Research Interests
Education, Medical
Public Health Interests
Health Care Quality, Efficiency; Qualitative Methods
ORCID
0000-0001-9956-7688
Research at a Glance
Publications Timeline
A big-picture view of Kelsey Koch's research output by year.
12Publications
82Citations
Publications
2024
Is Frailty Discouraging Surgeons from Performing Thoracolumbar Fusion? A Retrospective Study.
Linden B, Willging A, Chainani M, Koch K, Galet C, McGonagill P. Is Frailty Discouraging Surgeons from Performing Thoracolumbar Fusion? A Retrospective Study. Spine 2024 PMID: 39482285, DOI: 10.1097/brs.0000000000005203.Peer-Reviewed Original ResearchAltmetricConceptsThoracolumbar fracturesPre-frailtyPre-frailCSHA-CFSTrauma patientsFrail patientsFrailty scoreCanadian Study of Health and Aging Clinical Frailty ScaleThoracolumbar fusionSkilled nursing facilityAssociated with increased risk of pneumoniaOlder trauma patientsManagement of thoracolumbar fracturesAssociated with adverse outcomesAssociated with lower mortalityAssociated with poor outcomesAssociated with increased riskHospital length of stayClinical Frailty ScaleAdult trauma patientsRisk of pneumoniaIn-hospital mortalityNursing facilitiesLength of stayCanadian study
2021
Admission Lymphopenia is Associated With Discharge Disposition in Blunt Chest Wall Trauma Patients
Koch K, Troester A, Chevuru P, Campbell B, Galet C, McGonagill P. Admission Lymphopenia is Associated With Discharge Disposition in Blunt Chest Wall Trauma Patients. Journal Of Surgical Research 2021, 270: 293-299. PMID: 34717263, PMCID: PMC8712416, DOI: 10.1016/j.jss.2021.09.013.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBlunt chest wall traumaAbsolute lymphocyte countChest Abbreviated Injury ScoreAdmission lymphopeniaBlunt chest wall trauma patientsLevel I trauma centerInstitution's trauma registryAbbreviated Injury ScoreI trauma centerInjury Severity ScoreChest wall traumaImportant prognostic informationBowel perforationHospital deathHospital stayAdult patientsCritical illnessDischarge dispositionLymphocyte countTrauma patientsClinical outcomesInjury characteristicsTrauma centerTrauma registryImmune suppressionAP-2alpha-mediated activation of E2F and EZH2 drives melanoma metastasis
White J, Thompson D, Koch K, Kiriazov B, Beck A, van der Heide D, Grimm B, Kulak M, Weigel R. AP-2alpha-mediated activation of E2F and EZH2 drives melanoma metastasis. Cancer Research 2021, 81: canres.0772.2021. PMID: 34210752, PMCID: PMC8416798, DOI: 10.1158/0008-5472.can-21-0772.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdaptor Protein Complex 2Adaptor Protein Complex alpha SubunitsAnimalsBase SequenceBenzamidesBiomarkersBiphenyl CompoundsCell Line, TumorE2F Transcription FactorsEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticHumansMelanocytesMelanomaMiceMice, Inbred NODMice, SCIDMorpholinesNeoplasm MetastasisNeoplasm TransplantationNeoplasms, Second PrimaryPromoter Regions, GeneticPyridonesSingle-Cell AnalysisTranscription Factor AP-2ConceptsAP-2αRepression complexEZH2 inhibitorsAP-2α transcription factorSingle-cell RNA sequencing analysisE2F target genesRNA sequencing analysisSpecific EZH2 inhibitorsAP-2α expressionActivation of E2FAnchorage-independent colony formationMelanocyte stem cellsTumor suppressor activityChromatin marksNucleosome remodelingBioID screenE2F pathwayTranscriptional activationTranscription factorsTarget genesPathway genesAP-2alphaSequencing analysisMelanoma metastasesGenesMale sex, ostomy, infection, and intravenous fluids are associated with increased risk of postoperative ileus in elective colorectal surgery
Koch K, Hahn A, Hart A, Kahl A, Charlton M, Kapadia M, Hrabe J, Cromwell J, Hassan I, Gribovskaja-Rupp I. Male sex, ostomy, infection, and intravenous fluids are associated with increased risk of postoperative ileus in elective colorectal surgery. Surgery 2021, 170: 1325-1330. PMID: 34210525, DOI: 10.1016/j.surg.2021.05.035.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsElective colorectal surgeryAcute kidney injuryEnhanced recovery protocolPostoperative ileusIntravenous fluidsRenal functionMale sexColorectal resectionKidney injuryColorectal surgeryIleorectal anastomosisHigh riskTertiary academic medical centerRecovery protocolElective colorectal resectionIntravenous fluid administrationIntravenous fluid volumeNasogastric tube insertionAcademic medical centerIntestinal reconstructionNasogastric decompressionRenal damageSecondary outcomesColorectal anastomosisPostoperative infectionAP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer
Beck AC, Cho E, White JR, Paemka L, Li T, Gu VW, Thompson DT, Koch KE, Franke C, Gosse M, Wu VT, Landers SR, Pamatmat AJ, Kulak MV, Weigel RJ. AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer. Molecular Cancer Research 2021, 19: 1156-1167. PMID: 33753551, PMCID: PMC8254761, DOI: 10.1158/1541-7786.mcr-20-0867.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAminopyridinesAnimalsBiomarkers, TumorCell Line, TumorCell SurvivalColonic NeoplasmsGene Expression ProfilingGene Expression Regulation, NeoplasticGene Knockout TechniquesHCT116 CellsHumansMiceMorpholinesPhosphoinositide-3 Kinase InhibitorsRNA InterferenceRNA-SeqS PhaseTranscription Factor AP-2Xenograft Model Antitumor AssaysConceptsAP-2αPI3K inhibitorsColon cancer cell linesCell cycleS phasePrimary gene targetsK inhibitorsChromatin immunoprecipitation sequencingCancer cell linesPI3K cascadeProlonged S phaseCell linesActivation of AktShort hairpin RNAPhosphorylation of AktHistone H3Immunoprecipitation sequencingRNA sequencingPI3K inhibitionTarget genesK cascadeGene targetsTumor suppressorHairpin RNAColon cancer
2020
AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells
Gu VW, Cho E, Thompson DT, Cassady VC, Borcherding N, Koch KE, Wu VT, Lorenzen AW, van der Heide DM, White JR, Kulak MV, Williams T, Zhang W, Weigel RJ. AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells. Stem Cell Reports 2020, 16: 106-119. PMID: 33382976, PMCID: PMC7897584, DOI: 10.1016/j.stemcr.2020.12.002.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMammary stem cellsAP-2γMultipotent mammary stem cellsMammary gland ductal morphogenesisAP-2γ transcription factorMammary gland structureMammary gland developmentStem cellsMammary epithelial cellsAdult MaSCsBasal epitheliumDuctal outgrowthMammary developmentLuminal progenitorsConditional knockoutEpithelial cellsLuminal lineageMammary lineageDuctal morphogenesisGland developmentNumber of cellsRegenerative capacityGland structureExpression of genesCellsImpact of routine mismatch repair screening on genetic counseling and surgical management in colorectal cancer patients
Koch K, Goffredo P, Hrabe J, Gribovskaja-Rupp I, Snow A, Bellizzi A, Kapadia M. Impact of routine mismatch repair screening on genetic counseling and surgical management in colorectal cancer patients. The American Journal Of Surgery 2020, 222: 408-412. PMID: 33317812, DOI: 10.1016/j.amjsurg.2020.12.017.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsExtended resectionGenetic counselingResection extentColorectal cancerLynch syndromeCRC specimensMMR deficiencySingle-institution retrospective reviewMMR-deficient patientsSurgical resection extentColorectal cancer patientsMLH1 promoter hypermethylationMismatch repair deficiencyLynch syndrome diagnosisMMR testingRetrospective reviewSegmental resectionSurgical managementCancer patientsLS patientsPatientsResectionSyndrome diagnosisRepair deficiencyFurther studiesConducting a Needs Assessment of Surgery Residents Using SCORE Questions
Koch K, Hrabe J, Klingensmith M, Kapadia M. Conducting a Needs Assessment of Surgery Residents Using SCORE Questions. Journal Of The American College Of Surgeons 2020, 231: e191. DOI: 10.1016/j.jamcollsurg.2020.08.508.Peer-Reviewed Original ResearchTeaching Patient-Related Communication to Surgical Residents in Brief Training Sessions
Kapadia M, White A, Peters L, Kreiter C, Koch K, Rosenbaum M. Teaching Patient-Related Communication to Surgical Residents in Brief Training Sessions. Journal Of Surgical Education 2020, 77: 1496-1502. PMID: 32534941, DOI: 10.1016/j.jsurg.2020.05.006.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSurgical residency programsSurgical residentsEffective provider-patient communicationResidency programsProvider-patient communicationResidents' communication skillsTime-limited interventionSelf-reported useTertiary careClinical examinationHistory takingAcademic centersEligible residentsResident communicationRating ScalePatient interactionsBrief training sessionIndependent ratersCommunication skillsPostcurriculum scoresTraining sessionsBrief didacticsCommunication trainingScoresOSCE scoresA TFAP2C Gene Signature Is Predictive of Outcome in HER2-Positive Breast Cancer
Wu VT, Kiriazov B, Koch KE, Gu VW, Beck AC, Borcherding N, Li T, Addo P, Wehrspan ZJ, Zhang W, Braun TA, Brown BJ, Band V, Band H, Kulak MV, Weigel RJ. A TFAP2C Gene Signature Is Predictive of Outcome in HER2-Positive Breast Cancer. Molecular Cancer Research 2020, 18: 46-56. PMID: 31619506, PMCID: PMC6942205, DOI: 10.1158/1541-7786.mcr-19-0359.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBreast cancerGene signatureAP-2γHER2-positive breast cancerOutcomes of patientsExpression of estrogenSubset of patientsLuminal breast cancerSubset of HER2AP-2γ transcription factorBreast cancer subtypesPathway analysisPhysiologic effectsClinical relevanceCancer growthHER2Hormone responseCancer subtypesDifferent HER2CancerPatientsRetinoic acid pathwayCancer linesOutcomesCell lines
Academic Achievements & Community Involvement
honor Medical Student Surgery Clerkship Teaching Award
Regional AwardCaver College of Medicine, University of IowaDetails05/20/2022United Stateshonor Clinical Teaching Award
Regional AwardUniversity of Iowa Graduate Medical EducationDetails03/10/2022United Stateshonor Resident Educator of the Year
Regional AwardCarver College of Medicine, University of IowaDetails04/16/2021, 04/20/2018United Stateshonor Trauma Resident Paper Competition
Regional AwardAmerican College of Surgeons Committee on TraumaDetails09/18/2020United Stateshonor Make A Difference
Regional AwardUniversity of Iowa Hospitals and ClinicsDetails06/22/2018United States
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Yale School of Medicine
330 Cedar St
New Haven, CT 06510
United States