Featured Publications
Mapping data‐driven individualized neurobehavioral phenotypes in heavy alcohol drinkers
DeMartini KS, Gueorguieva R, Pearlson G, Krishnan‐Sarin S, Anticevic A, Ji LJ, Krystal JH, O’Malley S. Mapping data‐driven individualized neurobehavioral phenotypes in heavy alcohol drinkers. Alcohol Clinical And Experimental Research 2021, 45: 841-853. PMID: 33605439, DOI: 10.1111/acer.14580.Peer-Reviewed Original ResearchConceptsConfirmatory factor analysisIncentive salienceNeurofunctional domainsAlcohol use disorderExecutive functionLatent factorsPhysical neglectSelf-report measuresChildhood emotional abuseUse disordersChildhood physical neglectEarly life stressSignificant predictorsMultiple significant predictorsMultiple causes modelCurrent AUDNegative emotionalityAddiction developmentEmotional abuseChildhood neglectFactor structureDrinking frequencySalienceCause modelFactor analysis
2021
Effects of the Fyn kinase inhibitor saracatinib on ventral striatal activity during performance of an fMRI monetary incentive delay task in individuals family history positive or negative for alcohol use disorder. A pilot randomised trial
Patel KT, Stevens MC, Dunlap A, Gallagher A, O’Malley S, DeMartini K, Potenza MN, Krystal JH, Pearlson GD. Effects of the Fyn kinase inhibitor saracatinib on ventral striatal activity during performance of an fMRI monetary incentive delay task in individuals family history positive or negative for alcohol use disorder. A pilot randomised trial. Neuropsychopharmacology 2021, 47: 840-846. PMID: 34475522, PMCID: PMC8882177, DOI: 10.1038/s41386-021-01157-5.Peer-Reviewed Original ResearchConceptsProtein tyrosine kinasesSrc regulationSrc familyProtein kinaseTyrosine kinaseFyn kinaseSrc inhibitorSrc/FynDependent pathwayKinaseNMDAR upregulationNMDAR functionNMDA receptorsRegulationSaracatinibGluN2B subunitGlutamate receptorsFynInhibitorsReceptorsSubunitsN-methyl-D-aspartate (NMDA) glutamate receptorsPrevious evidence
2016
Urgency traits moderate daily relations between affect and drinking to intoxication among young adults
Bold KW, Fucito LM, DeMartini KS, Leeman RF, Kranzler HR, Corbin WR, O’Malley S. Urgency traits moderate daily relations between affect and drinking to intoxication among young adults. Drug And Alcohol Dependence 2016, 170: 59-65. PMID: 27875802, PMCID: PMC5183550, DOI: 10.1016/j.drugalcdep.2016.10.035.Peer-Reviewed Original ResearchConceptsYoung adultsHeavy drinkingEffectiveness of naltrexoneBlood alcohol concentrationHeavy drinking young adultsBrief motivational interventionNaltrexone treatmentClinical trialsHazardous drinkingNaltrexoneSecondary analysisPlaceboTargeted interventionsAge 18Alcohol useIntoxicationLow urgencyAdultsMotivational interventionDrinkingTrait urgencyOddsInterventionCurrent studyRisk
2015
Interactive and Indirect Effects of Anxiety and Negative Urgency on Alcohol‐Related Problems
Menary KR, Corbin WR, Leeman RF, Fucito LM, Toll BA, DeMartini K, O'Malley SS. Interactive and Indirect Effects of Anxiety and Negative Urgency on Alcohol‐Related Problems. Alcohol Clinical And Experimental Research 2015, 39: 1267-1274. PMID: 26031346, PMCID: PMC4490982, DOI: 10.1111/acer.12762.Peer-Reviewed Original ResearchConceptsNegative urgencyAlcohol problemsPotential moderatorsCoping-related drinking motivesDependence symptomsPrevention/intervention effortsNegative emotional statesIndirect effectsInteractive effectsAlcohol-related problemsCurrent cross-sectional studyAlcohol use disorderNegative affectDrinking motivesEmotional statesDrinking sampleModeration hypothesisIntervention effortsDirect interactive effectsAnxietyYoung adultsUse disordersLongitudinal dataModeratorPositive association
2010
Brief alcohol interventions for mandated college students: comparison of face‐to‐face counseling and computer‐delivered interventions
Carey K, Carey M, Henson J, Maisto S, DeMartini K. Brief alcohol interventions for mandated college students: comparison of face‐to‐face counseling and computer‐delivered interventions. Addiction 2010, 106: 528-537. PMID: 21059184, PMCID: PMC3058775, DOI: 10.1111/j.1360-0443.2010.03193.x.Peer-Reviewed Original Research
2009
The motivational context for mandated alcohol interventions for college students by gender and family history
Carey K, DeMartini K. The motivational context for mandated alcohol interventions for college students by gender and family history. Addictive Behaviors 2009, 35: 218-223. PMID: 19914002, PMCID: PMC2815154, DOI: 10.1016/j.addbeh.2009.10.011.Peer-Reviewed Original ResearchConceptsMotivational variablesAlcohol useAlcohol interventionsDecisional balanceCollege studentsMotivational contextIntrinsic motivationPeer normsMotivational factorsDrinking patternsAlcohol problemsCurrent alcohol useMore motivationMotivationSanction eventGender differencesBaseline assessmentFemale studentsPrevention interventionsStudentsInterventionMale studentsBiological riskGenderParticipants
2007
Individual-level interventions to reduce college student drinking: A meta-analytic review
Carey K, Scott-Sheldon L, Carey M, DeMartini K. Individual-level interventions to reduce college student drinking: A meta-analytic review. Addictive Behaviors 2007, 32: 2469-2494. PMID: 17590277, PMCID: PMC2144910, DOI: 10.1016/j.addbeh.2007.05.004.Peer-Reviewed Original ResearchConceptsAlcohol-related problemsCollege drinkersRisk college drinkersCollege student drinkingMeta-analytic reviewMaintenance of effectsIndividual-level interventionsNormative feedbackMean effect sizeMotivational interviewingComparison conditionStudent drinkingModerator analysesIntervention conditionAlcohol interventionsRisk reduction interventionsFace interventionsEfficacious interventionsStudy descriptorsIntervention componentsEffect sizeFuture researchPrevention interventionsReduction interventionsParticipant characteristics