About
Titles
Assistant Professor Adjunct, Psychiatry
Appointments
Departments & Organizations
- Cho Lab
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Katrin Preller's published research.
Brendan Adkinson
Clara Fonteneau, PhD
John Krystal, MD
John D Murray, PhD
Nicole Santamauro, MA
Zailyn Tamayo
Publications
2024
Neurobiological Correlates of Psychedelic Experiences and Psychedelic-Associated Adverse Effects
Rieser N, Schmidt T, Preller K. Neurobiological Correlates of Psychedelic Experiences and Psychedelic-Associated Adverse Effects. Current Topics In Behavioral Neurosciences 2024, 1-20. PMID: 39080245, DOI: 10.1007/7854_2024_507.Peer-Reviewed Original ResearchConceptsCortico-striato-thalamo-corticalPsychedelic experiencePathophysiology of psychiatric illnessPsychedelic drug actionEffects of psychedelicsHuman neuroimaging studiesAcute drug effectsEffects of psychedelic drugsEntropic brain hypothesisNeurobiological correlatesEgo dissolutionNeural correlatesNeurobiological mechanismsNeuroimaging studiesNeural mechanismsPsychiatric illnessPsychedelic drugsBrain hypothesisDrug effectsPET measurementsSubacute adverse effectsDrug actionGeneral effectEmotional impactLong-term adverse effectsNeural mechanisms of psychedelic visual imagery
Stoliker D, Preller K, Novelli L, Anticevic A, Egan G, Vollenweider F, Razi A. Neural mechanisms of psychedelic visual imagery. Molecular Psychiatry 2024, 1-8. PMID: 38862674, DOI: 10.1038/s41380-024-02632-3.Peer-Reviewed Original ResearchCitationsAltmetricConceptsVisual association regionsVisual imageryConsistent with preclinical findingsInferior frontal gyrusSerotonergic psychedelic drugTop-down feedback connectionsFunctional MRI scansVisual areasDynamic causal modelingEffective connectivity modelsTop-down connectionsEarly visual areasFusiform gyrusFrontal gyrusClassic psychedelicsIntraparietal sulcusBehavioral measuresNeural mechanismsPsychedelic experiencePsychedelic drugsConnectivity changesAffect balancePlacebo-controlledPreclinical findingsCausal modelThe influence of psilocybin on subconscious and conscious emotional learning
Casanova A, Ort A, Smallridge J, Preller K, Seifritz E, Vollenweider F. The influence of psilocybin on subconscious and conscious emotional learning. IScience 2024, 27: 110034. PMID: 38883812, PMCID: PMC11177198, DOI: 10.1016/j.isci.2024.110034.Peer-Reviewed Original ResearchAltmetricConceptsPsychedelic-assisted psychotherapyAgonist psilocybinFearful facesNeutral cuesEmotional cuesPsychiatric disordersSerotonergic psychedelicsSerotonin signalingExploratory behaviorPsilocybinEmotional learningLearning effectCuesPlacebo groupPlaceboPsychotherapyLearning rateLearningPsychedelicsSerotoninReinforcement learningDisordersTreatment modalitiesBrainTaskPsychedelics in Medicine: Can Evidence Keep Up With Enthusiasm?
de Wit H, Holze F, Preller K. Psychedelics in Medicine: Can Evidence Keep Up With Enthusiasm? Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 9: 460-461. PMID: 38719373, DOI: 10.1016/j.bpsc.2024.02.010.Peer-Reviewed Original ResearchMeSH KeywordsKetamine induces multiple individually distinct whole-brain functional connectivity signatures
Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsResponse to ketamineAcute ketamineBehavioral effectsQuantified resting-state functional connectivityEffects of acute ketamineSymptom variationResting-state functional connectivityTreatment-resistant depressionFunctional connectivity signaturesGlobal brain connectivitySingle-subject levelInter-individual variabilityPlacebo-controlled studyFunctional connectivityConnectivity signaturesBrain connectivityHealthy participantsSingle-blind placebo-controlled studyNeural variationsTreatment conditionsKetamineGene expression targetsPharmacological biomarkersPilot awardParvalbuminNeuroimaging Biomarkers for Drug Discovery and Development in Schizophrenia
Preller K, Scholpp J, Wunder A, Rosenbrock H. Neuroimaging Biomarkers for Drug Discovery and Development in Schizophrenia. Biological Psychiatry 2024, 96: 666-673. PMID: 38272287, DOI: 10.1016/j.biopsych.2024.01.009.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNMDA receptor hypofunctionPsychosis spectrum disordersNeuroimaging data acquisitionField of neuroimagingNegative symptomsPharmacological neuroimagingPositive symptomsReceptor hypofunctionPsychotic disordersNeuroimaging resultsSpectrum disorderNeuroimaging technologiesNeuroimaging biomarkersSchizophreniaNeuroimagingPathophysiology of symptomsDrug developmentDecades of researchTarget engagementClinical drug developmentPredictive biomarkersDisordersSymptomsHealthy volunteersDose selectionNeural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin
Stoliker D, Novelli L, Vollenweider F, Egan G, Preller K, Razi A. Neural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin. Biological Psychiatry 2024, 96: 57-66. PMID: 38185235, DOI: 10.1016/j.biopsych.2024.01.002.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCentral executive networkDefault mode networkResting-state networksEffective connectivitySalience networkNeural mechanismsAltered cognitionLarge-scale resting-state networksBasic cognitive functionsCognitive systemBehavioral measuresExecutive networkHierarchical organizationEmotional effectsMode networkCognitive functionSubcortical systemsSubjective experienceCognitionFunctional MRIPsychedelic therapyAmygdalaEmotionsHealthy adultsPsychiatric disordersKnowledge gaps in psychedelic medicalisation: Preclinical and neuroimaging mechanisms
McCulloch D, Lopez J, Dalla C, Castrén E, Erritzoe D, Frokjaer V, Lundberg J, Preller K, Fisher P, Knudsen G. Knowledge gaps in psychedelic medicalisation: Preclinical and neuroimaging mechanisms. Neuroscience Applied 2024, 3: 103929. DOI: 10.1016/j.nsa.2023.103929.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSerotonin 2A receptorFunctional brain activityMechanism of actionClinical effectsPreclinical modelsBrain disordersClinical neuroimagingDose optimizationNeurotransmitter releaseEffects of psychedelicsBrain activitySex differencesPsychedelic drugsMolecular mechanismsKnowledge gapsPsychedelicsAppropriate behavioral modelsPreclinicalNeuroimagingReceptorsAmygdala response to emotional faces following acute administration of psilocybin in healthy individuals
Armand S, Larsen K, Madsen M, Ozenne B, Preller K, Knudsen G, Stenbæk D, Fisher P. Amygdala response to emotional faces following acute administration of psilocybin in healthy individuals. Neuroscience Applied 2024, 3: 103934. DOI: 10.1016/j.nsa.2023.103934.Peer-Reviewed Original ResearchAltmetricConceptsPlasma psilocin levelsFunctional magnetic resonance imagingAmygdala reactivityHealthy individualsAmygdala responseMagnetic resonance imagingAcute administrationDrug intensityAcute exposureTherapeutic outcomesResonance imagingSignificant associationBrain regionsPsychedelic psilocybinPsilocybinBaselineFuture studiesSignificant changesExposureFearful facesEmotion processingResponseIndividualsAdministration
2023
Investigating functional brain connectivity patterns associated with two hypnotic states
de Matos N, Staempfli P, Seifritz E, Preller K, Bruegger M. Investigating functional brain connectivity patterns associated with two hypnotic states. Frontiers In Human Neuroscience 2023, 17: 1286336. PMID: 38192504, PMCID: PMC10773817, DOI: 10.3389/fnhum.2023.1286336.Peer-Reviewed Original ResearchCitationsAltmetricConceptsLingual gyrusFunctional brain connectivity patternsConnectivity changesUnbiased whole-brain analysesFunctional connectivity changesRegion-specific increaseFunctional connectivity patternsWhole-brain analysisBrain connectivity patternsConnectivity patternsHypnotic stateOccipital cortexOccipital poleClinical successTemporal areaNeural hubPlanum temporaleSupramarginal gyrusVoxel analysisGyrusFMRI studyNeurobiological underpinningsControl conditionHypnosis stateHypnosis