2010
Exploring the impact of gender and reproductive status on outcomes in a randomized clinical trial of naltrexone augmentation of nicotine patch
Epperson CN, Toll B, Wu R, Amin Z, Czarkowski KA, Jatlow P, Mazure CM, O’Malley S. Exploring the impact of gender and reproductive status on outcomes in a randomized clinical trial of naltrexone augmentation of nicotine patch. Drug And Alcohol Dependence 2010, 112: 1-8. PMID: 20561758, PMCID: PMC2946976, DOI: 10.1016/j.drugalcdep.2010.04.021.Peer-Reviewed Original ResearchConceptsPlacebo groupStudy completersNaltrexone doseClinical trialsContinuous abstinenceOral naltrexone treatmentNicotine patch therapyNicotine replacement therapyInteractive voice responseRandomized clinical trialsMenstrual cycle statusEffect of doseNaltrexone augmentationNaltrexone groupAdverse eventsNaltrexone treatmentNicotine patchPatch therapyReplacement therapyQuit dayWeek 1AbstinenceDoseWomenLess adherent
2005
Sex, GABA, and nicotine: The impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy
Epperson CN, O’Malley S, Czarkowski KA, Gueorguieva R, Jatlow P, Sanacora G, Rothman DL, Krystal JH, Mason GF. Sex, GABA, and nicotine: The impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy. Biological Psychiatry 2005, 57: 44-48. PMID: 15607299, PMCID: PMC4097033, DOI: 10.1016/j.biopsych.2004.09.021.Peer-Reviewed Original ResearchConceptsCortical GABA levelsOccipital cortex GABA concentrationsGABA levelsProton magnetic resonance spectroscopyImpact of nicotineMenstrual cycleGABA concentrationFemale smokersCortical gamma-aminobutyric acid (GABA) levelsUnderwent proton magnetic resonance spectroscopyGamma-aminobutyric acid (GABA) levelsCentral GABAergic functionCortical GABA concentrationsNicotine-dependent menAmino acid neurotransmissionImpact of smokingPotential risk factorsMenstrual cycle phaseShort-term abstinenceGABAergic functionNicotine modulationSmoking menSmoking cessationFollicular phaseSmoking abstinence