2015
New onset executive function difficulties at menopause: a possible role for lisdexamfetamine
Epperson CN, Shanmugan S, Kim DR, Mathews S, Czarkowski KA, Bradley J, Appleby DH, Iannelli C, Sammel MD, Brown TE. New onset executive function difficulties at menopause: a possible role for lisdexamfetamine. Psychopharmacology 2015, 232: 3091-3100. PMID: 26063677, PMCID: PMC4631394, DOI: 10.1007/s00213-015-3953-7.Peer-Reviewed Original ResearchConceptsBrown Attention-Deficit Disorder ScaleExecutive function difficultiesExecutive functionAttention Deficit Disorder ScaleLDX treatmentObjective cognitive functionMemory taskVerbal memoryVerbal recallCognitive measuresParagraph recallLifetime ADHDCognitive functionCognitive declineDisorder ScaleSubjective measuresMenopausal womenSubscale scoresLisdexamfetamineObjective measuresRecallEarly postmenopausal womenSystolic blood pressureCross-over studyHealthy menopausal women
2014
Selective Serotonin Reuptake Inhibitors and Endothelial Function in Women
Hantsoo L, Czarkowski KA, Child J, Howes C, Epperson CN. Selective Serotonin Reuptake Inhibitors and Endothelial Function in Women. Journal Of Women's Health 2014, 23: 613-618. PMID: 24886268, PMCID: PMC4089019, DOI: 10.1089/jwh.2013.4623.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBlood Flow VelocityBrachial ArteryDepression, PostpartumDepressive Disorder, MajorEndothelium, VascularFemaleFollow-Up StudiesHumansMiddle AgedNitric OxidePlatelet AggregationPremenstrual SyndromeSelective Serotonin Reuptake InhibitorsTreatment OutcomeUltrasonography, DopplerVasodilationYoung AdultConceptsSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsSSRI treatmentPremenstrual dysphoric disorderCardiovascular diseasePlatelet aggregationNO productionReuptake inhibitorsPostpartum depressionEffects of SSRIsBurden of diseasePlatelet NO productionDepression/anxietyNitric oxide functionSSRI therapyEndothelial functionVascular mechanismsVascular dilatationMajor depressionDysphoric disorderNormal rangeBeck DepressionYounger groupDiseaseWomen
2013
A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression
Hantsoo L, Ward-O’Brien D, Czarkowski KA, Gueorguieva R, Price LH, Epperson CN. A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression. Psychopharmacology 2013, 231: 939-948. PMID: 24173623, PMCID: PMC3945214, DOI: 10.1007/s00213-013-3316-1.Peer-Reviewed Original ResearchConceptsDSM-IV criteriaDouble-blind placebo-controlled trialSelective serotonin reuptake inhibitor sertralineSerotonin reuptake inhibitor sertralineClinical Global Impression scoresHamilton Depression Rating ScaleRating ScaleStrict DSM-IV criteriaDouble-blind trialPlacebo-controlled studyPlacebo-controlled trialHamilton Anxiety Rating ScaleMonths of deliverySubset of womenPrimary outcome variableWeeks of childbirthDepression Rating ScaleGlobal Impression scoresGreater response rateMajor depressive disorderOnset of depressionAnxiety Rating ScaleSignificant groupSertraline 50Remission rate
2011
The Relationship Between Bipolar Disorder, Seasonality, and Premenstrual Symptoms
Kim DR, Czarkowski KA, Epperson CN. The Relationship Between Bipolar Disorder, Seasonality, and Premenstrual Symptoms. Current Psychiatry Reports 2011, 13: 500-503. PMID: 21918807, PMCID: PMC4107419, DOI: 10.1007/s11920-011-0233-z.Peer-Reviewed Original ResearchImpact of atomoxetine on subjective attention and memory difficulties in perimenopausal and postmenopausal women
Epperson CN, Pittman B, Czarkowski KA, Bradley J, Quinlan DM, Brown TE. Impact of atomoxetine on subjective attention and memory difficulties in perimenopausal and postmenopausal women. Menopause The Journal Of The North American Menopause Society 2011, 18: 542-548. PMID: 21293309, PMCID: PMC4076798, DOI: 10.1097/gme.0b013e3181fcafd6.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderBrown Attention-Deficit Disorder ScaleCognitive difficultiesHistory of ADHDBehavioral assessmentSubjective cognitive difficultiesAttention Deficit Disorder ScaleAttention/concentrationConcentration/attentionShort-term memorySimilar cognitive impairmentsCluster scoresATX treatmentExecutive functionSubjective attentionMemory difficultiesHyperactivity disorderNeuropsychological testsNeuropsychological testingCognitive symptomsDisorder ScaleSubjective difficultyAtomoxetineCognitive impairmentMemory
2010
Defensive Projection, Superimposed On Simplistic Object Relations, Erodes Patient-Provider Relationships in High-Risk Pregnancy: an Empirical Investigation
Shahar G, Porcerelli JH, Kamoo R, Epperson CN, Czarkowski KA, Magriples U, Mayes LC. Defensive Projection, Superimposed On Simplistic Object Relations, Erodes Patient-Provider Relationships in High-Risk Pregnancy: an Empirical Investigation. Journal Of The American Psychoanalytic Association 2010, 58: 953-974. PMID: 21156840, PMCID: PMC4109280, DOI: 10.1177/0003065110392228.Peer-Reviewed Original ResearchExploring the impact of gender and reproductive status on outcomes in a randomized clinical trial of naltrexone augmentation of nicotine patch
Epperson CN, Toll B, Wu R, Amin Z, Czarkowski KA, Jatlow P, Mazure CM, O’Malley S. Exploring the impact of gender and reproductive status on outcomes in a randomized clinical trial of naltrexone augmentation of nicotine patch. Drug And Alcohol Dependence 2010, 112: 1-8. PMID: 20561758, PMCID: PMC2946976, DOI: 10.1016/j.drugalcdep.2010.04.021.Peer-Reviewed Original ResearchConceptsPlacebo groupStudy completersNaltrexone doseClinical trialsContinuous abstinenceOral naltrexone treatmentNicotine patch therapyNicotine replacement therapyInteractive voice responseRandomized clinical trialsMenstrual cycle statusEffect of doseNaltrexone augmentationNaltrexone groupAdverse eventsNaltrexone treatmentNicotine patchPatch therapyReplacement therapyQuit dayWeek 1AbstinenceDoseWomenLess adherent
2007
The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings
Epperson CN, Amin Z, Naftolin F, Cappiello A, Czarkowski KA, Stiklus S, Anderson GM, Krystal JH. The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings. Journal Of Psychopharmacology 2007, 21: 414-420. PMID: 16891341, DOI: 10.1177/0269881106067330.Peer-Reviewed Original ResearchConceptsMenopausal womenTryptophan depletionSelective serotonin reuptake inhibitor fluoxetineAcute tryptophan depletion paradigmSerotonin reuptake inhibitor fluoxetineTryptophan depletion paradigmPathogenesis of depressionReuptake inhibitor fluoxetineMajor depressive episodeAcute tryptophan depletionRelapse of depressionWorsening of moodWeeks of recoveryActive tryptophan depletionWechsler Memory ScaleAssessment of moodDepressive episodeRisk factorsDepressive relapseMajor depressionSignificant worseningNeuroendocrine functionVerbal memorySerotonergic contributionMemory ScaleLuteal-Phase Accentuation of Acoustic Startle Response in Women with Premenstrual Dysphoric Disorder
Epperson CN, Pittman B, Czarkowski KA, Stiklus S, Krystal JH, Grillon C. Luteal-Phase Accentuation of Acoustic Startle Response in Women with Premenstrual Dysphoric Disorder. Neuropsychopharmacology 2007, 32: 2190-2198. PMID: 17314917, PMCID: PMC2713599, DOI: 10.1038/sj.npp.1301351.Peer-Reviewed Original ResearchConceptsPremenstrual dysphoric disorderMenstrual cycle phaseMenstrual cycleHealthy womenFollicular phaseDysphoric disorderLuteal phasePhysiologic responsesMenstrual cycle-related fluctuationsStartle magnitudeCentral nervous system responseHealthy menstruating womenAcoustic startle responseAcoustic startle paradigmNervous system responsesPowerful modulatory effectsStartle response magnitudeVisual affective stimuliNeuroactive steroidsMenstruating womenASR magnitudeModulatory effectsCycle phaseNeuroendocrine milieuAcoustic startle response magnitudes
2006
Estradiol and Tryptophan Depletion Interact to Modulate Cognition in Menopausal Women
Amin Z, Gueorguieva R, Cappiello A, Czarkowski KA, Stiklus S, Anderson GM, Naftolin F, Epperson CN. Estradiol and Tryptophan Depletion Interact to Modulate Cognition in Menopausal Women. Neuropsychopharmacology 2006, 31: 2489-2497. PMID: 16760926, DOI: 10.1038/sj.npp.1301114.Peer-Reviewed Original ResearchConceptsVerbal memory performanceVerbal memory scoresPositive mood effectsVerbal memoryVisuospatial learningMemory performanceVerbal fluencyMemory scoresMood effectsEstrogen treatmentSubjects designCognitionTryptophan depletionMenopausal womenLittle researchSignificant interactionHealthy menopausal womenLast menstrual periodNonreproductive behaviorsInteraction of estrogenActive TrPsOvarian steroidsMenstrual periodProtective effectFluencyPreliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study
Epperson CN, Gueorguieva R, Czarkowski KA, Stiklus S, Sellers E, Krystal JH, Rothman DL, Mason GF. Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Psychopharmacology 2006, 186: 425. PMID: 16724188, DOI: 10.1007/s00213-006-0313-7.Peer-Reviewed Original ResearchConceptsPostpartum major depressionCortical GABA concentrationsGABA concentrationPostpartum womenOccipital cortex GABA concentrationsOccipital cortex GABA levelsProton magnetic resonance spectroscopy studyFollicular phase femalesGamma-aminobutyric acid concentrationResumption of menstruationFollicular phase womenMonths of deliveryMid-follicular phaseOvarian hormone levelsSubgroup of womenMagnetic resonance spectroscopy studyAllopregnanolone concentrationsPuerperal womenALLO levelsBlood levelsPostpartum periodHealthy controlsMajor depressionGABA levelsHormone levels
2005
Sex, GABA, and nicotine: The impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy
Epperson CN, O’Malley S, Czarkowski KA, Gueorguieva R, Jatlow P, Sanacora G, Rothman DL, Krystal JH, Mason GF. Sex, GABA, and nicotine: The impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy. Biological Psychiatry 2005, 57: 44-48. PMID: 15607299, PMCID: PMC4097033, DOI: 10.1016/j.biopsych.2004.09.021.Peer-Reviewed Original ResearchConceptsCortical GABA levelsOccipital cortex GABA concentrationsGABA levelsProton magnetic resonance spectroscopyImpact of nicotineMenstrual cycleGABA concentrationFemale smokersCortical gamma-aminobutyric acid (GABA) levelsUnderwent proton magnetic resonance spectroscopyGamma-aminobutyric acid (GABA) levelsCentral GABAergic functionCortical GABA concentrationsNicotine-dependent menAmino acid neurotransmissionImpact of smokingPotential risk factorsMenstrual cycle phaseShort-term abstinenceGABAergic functionNicotine modulationSmoking menSmoking cessationFollicular phaseSmoking abstinence
2004
Platelet Serotonin in Newborns and Infants: Ontogeny, Heritability, and Effect of In Utero Exposure to Selective Serotonin Reuptake Inhibitors
Anderson GM, Czarkowski K, Ravski N, Epperson CN. Platelet Serotonin in Newborns and Infants: Ontogeny, Heritability, and Effect of In Utero Exposure to Selective Serotonin Reuptake Inhibitors. Pediatric Research 2004, 56: 418-422. PMID: 15240861, DOI: 10.1203/01.pdr.0000136278.23672.a0.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitorsReuptake inhibitorsUtero exposureCord bloodPlatelet serotoninSelective serotonin reuptake inhibitorsMean cord bloodMother-infant pairsMother-child pairsPlatelet serotonin levelsImportant physiologic effectsMo of ageGestational exposureLarge adult populationSerotonin levelsPhysiologic effectsLow bloodNewbornsAdult populationInfantsNew bornsAdult levelsOlder childrenSuch exposureBlood
2003
Maternal Fluoxetine Treatment in the Postpartum Period: Effects on Platelet Serotonin and Plasma Drug Levels in Breastfeeding Mother-Infant Pairs
Epperson CN, Jatlow PI, Czarkowski K, Anderson GM. Maternal Fluoxetine Treatment in the Postpartum Period: Effects on Platelet Serotonin and Plasma Drug Levels in Breastfeeding Mother-Infant Pairs. Pediatrics 2003, 112: e425-e425. PMID: 14595087, DOI: 10.1542/peds.112.5.e425.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsMother-infant pairsPlasma drug levelsHigh plasma drug levelsMaternal fluoxetine treatmentBreast milkMeasurement of plateletDrug levelsMonths of ageTransporter blockadePostpartum depressionSSRI exposureFluoxetine treatmentFluoxetine levelsSpecific selective serotonin reuptake inhibitorsSerotonin transporterNeuronal serotonin transporterPostpartum major depressionStudy of sertralineMother's breast milkSerotonin reuptake inhibitorsInfant 4 monthsPlatelet serotonin levelsHuman Investigation CommitteeSubsequent development
2001
Maternal Sertraline Treatment and Serotonin Transport in Breast-Feeding Mother-Infant Pairs
Epperson N, Czarkowski KA, Ward-O'Brien D, Weiss E, Gueorguieva R, Jatlow P, Anderson GM. Maternal Sertraline Treatment and Serotonin Transport in Breast-Feeding Mother-Infant Pairs. American Journal Of Psychiatry 2001, 158: 1631-1637. PMID: 11578995, DOI: 10.1176/appi.ajp.158.10.1631.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsPlasma sertralineSertraline treatmentTransporter blockadeBreast-feeding mother-infant pairsMaternal breast milkBreast feeding mothersBreast milk levelsSerotonin reuptake inhibitorsDrug metabolite concentrationsMother-infant pairsSSRI exposureReuptake inhibitorsInfant pairsMaternal treatmentPostpartum onsetBreast milkPharmacological treatmentNursing infantsNursing resultsSerotonin reuptakePlatelet levelsClinical dosesPostpartum depressionMajor depression