2007
The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings
Epperson CN, Amin Z, Naftolin F, Cappiello A, Czarkowski KA, Stiklus S, Anderson GM, Krystal JH. The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings. Journal Of Psychopharmacology 2007, 21: 414-420. PMID: 16891341, DOI: 10.1177/0269881106067330.Peer-Reviewed Original ResearchConceptsMenopausal womenTryptophan depletionSelective serotonin reuptake inhibitor fluoxetineAcute tryptophan depletion paradigmSerotonin reuptake inhibitor fluoxetineTryptophan depletion paradigmPathogenesis of depressionReuptake inhibitor fluoxetineMajor depressive episodeAcute tryptophan depletionRelapse of depressionWorsening of moodWeeks of recoveryActive tryptophan depletionWechsler Memory ScaleAssessment of moodDepressive episodeRisk factorsDepressive relapseMajor depressionSignificant worseningNeuroendocrine functionVerbal memorySerotonergic contributionMemory Scale
2003
Maternal Fluoxetine Treatment in the Postpartum Period: Effects on Platelet Serotonin and Plasma Drug Levels in Breastfeeding Mother-Infant Pairs
Epperson CN, Jatlow PI, Czarkowski K, Anderson GM. Maternal Fluoxetine Treatment in the Postpartum Period: Effects on Platelet Serotonin and Plasma Drug Levels in Breastfeeding Mother-Infant Pairs. Pediatrics 2003, 112: e425-e425. PMID: 14595087, DOI: 10.1542/peds.112.5.e425.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsMother-infant pairsPlasma drug levelsHigh plasma drug levelsMaternal fluoxetine treatmentBreast milkMeasurement of plateletDrug levelsMonths of ageTransporter blockadePostpartum depressionSSRI exposureFluoxetine treatmentFluoxetine levelsSpecific selective serotonin reuptake inhibitorsSerotonin transporterNeuronal serotonin transporterPostpartum major depressionStudy of sertralineMother's breast milkSerotonin reuptake inhibitorsInfant 4 monthsPlatelet serotonin levelsHuman Investigation CommitteeSubsequent development