2014
Selective Serotonin Reuptake Inhibitors and Endothelial Function in Women
Hantsoo L, Czarkowski KA, Child J, Howes C, Epperson CN. Selective Serotonin Reuptake Inhibitors and Endothelial Function in Women. Journal Of Women's Health 2014, 23: 613-618. PMID: 24886268, PMCID: PMC4089019, DOI: 10.1089/jwh.2013.4623.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBlood Flow VelocityBrachial ArteryDepression, PostpartumDepressive Disorder, MajorEndothelium, VascularFemaleFollow-Up StudiesHumansMiddle AgedNitric OxidePlatelet AggregationPremenstrual SyndromeSelective Serotonin Reuptake InhibitorsTreatment OutcomeUltrasonography, DopplerVasodilationYoung AdultConceptsSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsSSRI treatmentPremenstrual dysphoric disorderCardiovascular diseasePlatelet aggregationNO productionReuptake inhibitorsPostpartum depressionEffects of SSRIsBurden of diseasePlatelet NO productionDepression/anxietyNitric oxide functionSSRI therapyEndothelial functionVascular mechanismsVascular dilatationMajor depressionDysphoric disorderNormal rangeBeck DepressionYounger groupDiseaseWomen
2013
A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression
Hantsoo L, Ward-O’Brien D, Czarkowski KA, Gueorguieva R, Price LH, Epperson CN. A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression. Psychopharmacology 2013, 231: 939-948. PMID: 24173623, PMCID: PMC3945214, DOI: 10.1007/s00213-013-3316-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsDepression, PostpartumDouble-Blind MethodFemaleHumansPlacebosSelective Serotonin Reuptake InhibitorsSertralineConceptsDSM-IV criteriaDouble-blind placebo-controlled trialSelective serotonin reuptake inhibitor sertralineSerotonin reuptake inhibitor sertralineClinical Global Impression scoresHamilton Depression Rating ScaleRating ScaleStrict DSM-IV criteriaDouble-blind trialPlacebo-controlled studyPlacebo-controlled trialHamilton Anxiety Rating ScaleMonths of deliverySubset of womenPrimary outcome variableWeeks of childbirthDepression Rating ScaleGlobal Impression scoresGreater response rateMajor depressive disorderOnset of depressionAnxiety Rating ScaleSignificant groupSertraline 50Remission rate
2007
The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings
Epperson CN, Amin Z, Naftolin F, Cappiello A, Czarkowski KA, Stiklus S, Anderson GM, Krystal JH. The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings. Journal Of Psychopharmacology 2007, 21: 414-420. PMID: 16891341, DOI: 10.1177/0269881106067330.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffectCognitionDepressive Disorder, MajorDrug Therapy, CombinationEstradiolFemaleFluoxetineHumansMenopauseMiddle AgedPilot ProjectsRecurrenceRisk FactorsSelective Serotonin Reuptake InhibitorsSerotoninTryptophanConceptsMenopausal womenTryptophan depletionSelective serotonin reuptake inhibitor fluoxetineAcute tryptophan depletion paradigmSerotonin reuptake inhibitor fluoxetineTryptophan depletion paradigmPathogenesis of depressionReuptake inhibitor fluoxetineMajor depressive episodeAcute tryptophan depletionRelapse of depressionWorsening of moodWeeks of recoveryActive tryptophan depletionWechsler Memory ScaleAssessment of moodDepressive episodeRisk factorsDepressive relapseMajor depressionSignificant worseningNeuroendocrine functionVerbal memorySerotonergic contributionMemory Scale
2004
Platelet Serotonin in Newborns and Infants: Ontogeny, Heritability, and Effect of In Utero Exposure to Selective Serotonin Reuptake Inhibitors
Anderson GM, Czarkowski K, Ravski N, Epperson CN. Platelet Serotonin in Newborns and Infants: Ontogeny, Heritability, and Effect of In Utero Exposure to Selective Serotonin Reuptake Inhibitors. Pediatric Research 2004, 56: 418-422. PMID: 15240861, DOI: 10.1203/01.pdr.0000136278.23672.a0.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PlateletsFemaleFetal BloodHumansInfantInfant, NewbornMaleMaternal ExposurePregnancySelective Serotonin Reuptake InhibitorsSerotoninStatistics as TopicConceptsSerotonin reuptake inhibitorsReuptake inhibitorsUtero exposureCord bloodPlatelet serotoninSelective serotonin reuptake inhibitorsMean cord bloodMother-infant pairsMother-child pairsPlatelet serotonin levelsImportant physiologic effectsMo of ageGestational exposureLarge adult populationSerotonin levelsPhysiologic effectsLow bloodNewbornsAdult populationInfantsNew bornsAdult levelsOlder childrenSuch exposureBlood
2003
Maternal Fluoxetine Treatment in the Postpartum Period: Effects on Platelet Serotonin and Plasma Drug Levels in Breastfeeding Mother-Infant Pairs
Epperson CN, Jatlow PI, Czarkowski K, Anderson GM. Maternal Fluoxetine Treatment in the Postpartum Period: Effects on Platelet Serotonin and Plasma Drug Levels in Breastfeeding Mother-Infant Pairs. Pediatrics 2003, 112: e425-e425. PMID: 14595087, DOI: 10.1542/peds.112.5.e425.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PlateletsDepressive DisorderFemaleFluoxetineHalf-LifeHumansInfantInfant, NewbornMilk, HumanPuerperal DisordersSelective Serotonin Reuptake InhibitorsSerotoninConceptsSelective serotonin reuptake inhibitorsMother-infant pairsPlasma drug levelsHigh plasma drug levelsMaternal fluoxetine treatmentBreast milkMeasurement of plateletDrug levelsMonths of ageTransporter blockadePostpartum depressionSSRI exposureFluoxetine treatmentFluoxetine levelsSpecific selective serotonin reuptake inhibitorsSerotonin transporterNeuronal serotonin transporterPostpartum major depressionStudy of sertralineMother's breast milkSerotonin reuptake inhibitorsInfant 4 monthsPlatelet serotonin levelsHuman Investigation CommitteeSubsequent development
2001
Maternal Sertraline Treatment and Serotonin Transport in Breast-Feeding Mother-Infant Pairs
Epperson N, Czarkowski KA, Ward-O'Brien D, Weiss E, Gueorguieva R, Jatlow P, Anderson GM. Maternal Sertraline Treatment and Serotonin Transport in Breast-Feeding Mother-Infant Pairs. American Journal Of Psychiatry 2001, 158: 1631-1637. PMID: 11578995, DOI: 10.1176/appi.ajp.158.10.1631.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsPlasma sertralineSertraline treatmentTransporter blockadeBreast-feeding mother-infant pairsMaternal breast milkBreast feeding mothersBreast milk levelsSerotonin reuptake inhibitorsDrug metabolite concentrationsMother-infant pairsSSRI exposureReuptake inhibitorsInfant pairsMaternal treatmentPostpartum onsetBreast milkPharmacological treatmentNursing infantsNursing resultsSerotonin reuptakePlatelet levelsClinical dosesPostpartum depressionMajor depression