2006
Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study
Epperson CN, Gueorguieva R, Czarkowski KA, Stiklus S, Sellers E, Krystal JH, Rothman DL, Mason GF. Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Psychopharmacology 2006, 186: 425. PMID: 16724188, DOI: 10.1007/s00213-006-0313-7.Peer-Reviewed Original ResearchConceptsPostpartum major depressionCortical GABA concentrationsGABA concentrationPostpartum womenOccipital cortex GABA concentrationsOccipital cortex GABA levelsProton magnetic resonance spectroscopy studyFollicular phase femalesGamma-aminobutyric acid concentrationResumption of menstruationFollicular phase womenMonths of deliveryMid-follicular phaseOvarian hormone levelsSubgroup of womenMagnetic resonance spectroscopy studyAllopregnanolone concentrationsPuerperal womenALLO levelsBlood levelsPostpartum periodHealthy controlsMajor depressionGABA levelsHormone levels
2003
Maternal Fluoxetine Treatment in the Postpartum Period: Effects on Platelet Serotonin and Plasma Drug Levels in Breastfeeding Mother-Infant Pairs
Epperson CN, Jatlow PI, Czarkowski K, Anderson GM. Maternal Fluoxetine Treatment in the Postpartum Period: Effects on Platelet Serotonin and Plasma Drug Levels in Breastfeeding Mother-Infant Pairs. Pediatrics 2003, 112: e425-e425. PMID: 14595087, DOI: 10.1542/peds.112.5.e425.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsMother-infant pairsPlasma drug levelsHigh plasma drug levelsMaternal fluoxetine treatmentBreast milkMeasurement of plateletDrug levelsMonths of ageTransporter blockadePostpartum depressionSSRI exposureFluoxetine treatmentFluoxetine levelsSpecific selective serotonin reuptake inhibitorsSerotonin transporterNeuronal serotonin transporterPostpartum major depressionStudy of sertralineMother's breast milkSerotonin reuptake inhibitorsInfant 4 monthsPlatelet serotonin levelsHuman Investigation CommitteeSubsequent development