HIV-1 Entry and Macrophage Inflammatory Protein-1β-mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5*
Farzan M, Choe H, Martin K, Sun Y, Sidelko M, Mackay C, Gerard N, Sodroski J, Gerard C. HIV-1 Entry and Macrophage Inflammatory Protein-1β-mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5*. Journal Of Biological Chemistry 1997, 272: 6854-6857. PMID: 9054370, DOI: 10.1074/jbc.272.11.6854.Peer-Reviewed Original ResearchConceptsHIV-1 entryInflammatory protein-1betaChemokine receptor CCR5Viral entryReceptor CCR5Macrophage inflammatory protein-1βHuman immunodeficiency virus type 1Immunodeficiency virus type 1Ability of CCR5Only viral entrySpecific chemokine receptorsInflammatory protein-1βMacrophage-tropic strainsVirus type 1Wild-type CCR5CCR5 mutantsMCP-1Asymptomatic stageChemokine receptorsHIV-1CCR5Virus life cycleChemokine signalingType 1Target cells