2023
Serum Response Factor Reduces Gene Expression Noise and Confers Cell State Stability
Zhang J, Wu Q, Hu X, Wang Y, Lu J, Chakraborty R, Martin K, Guo S. Serum Response Factor Reduces Gene Expression Noise and Confers Cell State Stability. Stem Cells 2023, 41: 907-915. PMID: 37386941, PMCID: PMC11009695, DOI: 10.1093/stmcls/sxad051.Peer-Reviewed Original ResearchConceptsMouse pluripotent stem cellsSerum response factorPluripotent stem cellsCell fate stabilityRole of SRFGene expression noiseHeterogeneous gene expressionResponse factorStem cellsNaïve pluripotencyCell state heterogeneityLineage primingExpression noiseActin dynamicsCellular statesPluripotent cellsSRF functionCell statesMechanical signalingGene expressionFunctional modulationCentral mediatorSerum-containing culturesState heterogeneityCells
1997
A Competitive Mechanism of CArG Element Regulation by YY1 and SRF: Implications for Assessment of Phox1/MHox Transcription Factor Interactions at CArG Elements
Martin K, Gualberto A, Kolman M, Lowry J, Walsh K. A Competitive Mechanism of CArG Element Regulation by YY1 and SRF: Implications for Assessment of Phox1/MHox Transcription Factor Interactions at CArG Elements. DNA And Cell Biology 1997, 16: 653-661. PMID: 9174170, DOI: 10.1089/dna.1997.16.653.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCells, CulturedChick EmbryoDNA-Binding ProteinsErythroid-Specific DNA-Binding FactorsGene Expression RegulationHomeodomain ProteinsMuscle, SkeletalNuclear ProteinsPoint MutationPromoter Regions, GeneticSequence Analysis, DNASerum Response FactorTranscription FactorsYY1 Transcription FactorConceptsSerum response factorMuscle-specific expressionCArG elementsTranscription factor serum response factorTranscription factor interactionsDNA regulatory elementsMuscle-specific genesSkeletal alpha-actinImmediate early genesCArG boxSRF bindingTranscriptional activationRegulatory elementsPoint mutantsYY1 repressionSerum inductionYY1Regulatory factorsEarly genesYY1 overexpressionAlpha-actinRepressionPoint mutationsResponse factorMutants