2018
Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition
Ying LD, Breuer GA, Hubbard MO, Nadzam GS, Hwa J, Martin KA. Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition. Obesity Surgery 2018, 29: 593-600. PMID: 30353248, PMCID: PMC6365182, DOI: 10.1007/s11695-018-3555-7.Peer-Reviewed Original ResearchConceptsIleal transpositionSleeve gastrectomySham surgeryMouse modelReproducible mouse modelIntestinal identityQuantitative polymerase chain reactionBackgroundSleeve gastrectomySham procedureC57BL/6J miceObesogenic dietPolymerase chain reactionGastrectomyMurine modelPorcine modelWeight gainWeight lossMiceChain reactionMolecular pathwaysGene expression analysisWeeksFuture studiesLong-term survivabilityTechnical feasibility
2017
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
Fuster JJ, MacLauchlan S, Zuriaga MA, Polackal MN, Ostriker AC, Chakraborty R, Wu CL, Sano S, Muralidharan S, Rius C, Vuong J, Jacob S, Muralidhar V, Robertson AA, Cooper MA, Andrés V, Hirschi KK, Martin KA, Walsh K. Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science 2017, 355: 842-847. PMID: 28104796, PMCID: PMC5542057, DOI: 10.1126/science.aag1381.Peer-Reviewed Original ResearchConceptsTET2-deficient cellsLow-density lipoprotein receptor-deficient miceLipoprotein receptor-deficient miceClonal hematopoiesisBlood cellsAtherosclerotic cardiovascular diseaseAtherosclerotic plaque sizeReceptor-deficient miceBone marrow reconstitutionInterleukin-1β secretionMutant blood cellsAtherosclerosis developmentNLRP3 inhibitorAtheroprotective activityCardiovascular diseaseMarrow reconstitutionChimeric micePlaque sizeClonal expansionMiceMarked increaseCausal roleTET2 deficiencySomatic mutationsHematopoietic cells