1997
Down-Regulation of P2U-Purinergic Nucleotide Receptor Messenger RNA Expression During In Vitro Differentiation of Human Myeloid Leukocytes by Phorbol Esters or Inflammatory Activators
Martin K, Kertesy S, Dubyak G. Down-Regulation of P2U-Purinergic Nucleotide Receptor Messenger RNA Expression During In Vitro Differentiation of Human Myeloid Leukocytes by Phorbol Esters or Inflammatory Activators. Molecular Pharmacology 1997, 51: 97-108. PMID: 9016351, DOI: 10.1124/mol.51.1.97.Peer-Reviewed Original ResearchConceptsTHP-1 monocytesHL-60 cellsMRNA levelsMyeloid leukocytesReceptor messenger RNA expressionMonocyte/macrophage phenotypeMessenger RNA expressionInositol phospholipid hydrolysisNeutrophil phenotypeInflammatory activationHL-60 granulocytesUndifferentiated HL-60 cellsInflammatory activatorsInflammatory macrophagesAcute exposureMacrophage phenotypeNucleotide receptorsHuman epithelial cellsTissue-specific mechanismsEpithelial cellsRNA expressionLeukocytesDown regulationDibutyryl cAMPHuman keratinocytes
1996
Recruitment of purinergically stimulated Cl- channels from granule membrane to plasma membrane
Merlin D, Guo X, Martin K, Laboisse C, Landis D, Dubyak G, Hopfer U. Recruitment of purinergically stimulated Cl- channels from granule membrane to plasma membrane. American Journal Of Physiology 1996, 271: c612-c619. PMID: 8770002, DOI: 10.1152/ajpcell.1996.271.2.c612.Peer-Reviewed Original ResearchConceptsHT29-ClGranule fusionCl- channelsFungal metabolite wortmanninCAMP-activated Cl- channelMucin granulesCell linesRegulated exocytosisWortmannin concentrationsPlasma membraneActin depolymerizationWortmannin inhibitionCell line HT-29Granule membranesExtracellular ATPEpithelial cellsFusion inhibitorsHuman adenocarcinoma cell line HT-29WortmanninSecretion releaseCl- conductancePhalloidinMembraneDifferential inhibitionHT-29