2023
Role of ascorbic acid in cardiac allograft vasculopathy
Chang A, Martin K, Colvin M, Bellumkonda L. Role of ascorbic acid in cardiac allograft vasculopathy. Clinical Transplantation 2023, 37: e15153. PMID: 37792313, DOI: 10.1111/ctr.15153.Peer-Reviewed Original ResearchConceptsCardiac allograft vasculopathySmooth muscle cell apoptosisAllograft vasculopathyDisease processMuscle cell apoptosisSignificant long-term morbidityCell apoptosisProgressive fibroproliferative diseasePost-transplant carePost-transplant managementLong-term morbiditySmall clinical trialsChallenging disease processVascular smooth muscle cell apoptosisHeart transplantationCAV progressionEndothelial dysfunctionRapamycin inhibitorsClinical trialsIntimal thickeningPrevents developmentInterferon γRodent modelsIntimal hyperplasiaMTOR inhibitors
2006
The prostacyclin receptor induces human vascular smooth muscle cell differentiation via PKA
Fetalvero K, Shyu M, Nomikos A, Chiu Y, Wagner R, Powell R, Hwa J, Martin K. The prostacyclin receptor induces human vascular smooth muscle cell differentiation via PKA. The FASEB Journal 2006, 20: a665-a666. DOI: 10.1096/fasebj.20.4.a665-d.Peer-Reviewed Original ResearchVascular smooth muscle cellsHuman vascular smooth muscle cellsCardiovascular eventsHuman vascular smooth muscle cell differentiationProstacyclin receptorVSMC phenotypeSelective COX-2 inhibitorsAdverse cardiovascular eventsSuperficial femoral arteryProstacyclin analogue iloprostCOX-2 inhibitorsSmooth muscle cellsCAMP/PKA signalingVascular smooth muscle cell differentiationSmooth muscle differentiation markersSmooth muscle cell differentiationArterial injuryCardioprotective effectsFemoral arteryAnalogue iloprostClinical trialsH-caldesmonOrgan donorsAnimal modelsNM iloprost