2024
Rate of clinically significant red blood cell antibody seroconversion in pregnancy
Ding J, Abels E, Jacobs J, Culhane J, Lundsberg L, Partridge C, Denoble A, Kohari K. Rate of clinically significant red blood cell antibody seroconversion in pregnancy. The Journal Of Maternal-Fetal & Neonatal Medicine 2024, 37: 2419370. PMID: 39462637, DOI: 10.1080/14767058.2024.2419370.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitAdvanced maternal ageAssociated with seroconversionClinically significant antibodiesAntibody screeningNeonatal outcomesIncreasing gravidityAntibody seroconversionInitial hemoglobinMaternal ageSignificant antibodiesAntibody statusNeonatal intensive care unit admissionCohort studyClinically significant RBC antibodiesAnti-CUnexplained fetal lossPositive antibody screenNegative antibody screenCases of stillbirthRetrospective cohort studyIntensive care unitWilcoxon rank-sumMaternal antibody statusPostnatal transfusion
2022
Impact of prenatally diagnosed congenital heart defects on outcomes and management
Wong J, Kohari K, Bahtiyar MO, Copel J. Impact of prenatally diagnosed congenital heart defects on outcomes and management. Journal Of Clinical Ultrasound 2022, 50: 646-654. PMID: 35543387, DOI: 10.1002/jcu.23219.Peer-Reviewed Original ResearchConceptsCongenital heart defectsComplex congenital heart defectEarly fetal echocardiographyImproved survival ratesPrenatal detection rateGood psychosocial supportFetal echocardiogramFetal echocardiographyPatient educationCardiology specialistsHigh riskHeart defectsSurvival rateCongenital heartPsychosocial supportEarly detectionPrenatal identificationPrenatal detectionDelivery planningDetection rateUltrasound technologyImportant contributorEchocardiogramEchocardiographyNeonates
2021
Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis
Ovadia C, Sajous J, Seed PT, Patel K, Williamson NJ, Attilakos G, Azzaroli F, Bacq Y, Batsry L, Broom K, Brun-Furrer R, Bull L, Chambers J, Cui Y, Ding M, Dixon PH, Estiú MC, Gardiner FW, Geenes V, Grymowicz M, Günaydin B, Hague WM, Haslinger C, Hu Y, Indraccolo U, Juusela A, Kane SC, Kebapcilar A, Kebapcilar L, Kohari K, Kondrackienė J, Koster MPH, Lee RH, Liu X, Locatelli A, Macias RIR, Madazli R, Majewska A, Maksym K, Marathe JA, Morton A, Oudijk MA, Öztekin D, Peek MJ, Shennan AH, Tribe RM, Tripodi V, Özterlemez N, Vasavan T, Wong LFA, Yinon Y, Zhang Q, Zloto K, Marschall HU, Thornton J, Chappell LC, Williamson C. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis. The Lancet Gastroenterology & Hepatology 2021, 6: 547-558. PMID: 33915090, PMCID: PMC8192305, DOI: 10.1016/s2468-1253(21)00074-1.Peer-Reviewed Original ResearchConceptsUrsodeoxycholic acid treatmentPrevalence of stillbirthIndividual participant dataIntrahepatic cholestasisBile acid concentrationsUrsodeoxycholic acidComposite outcomeParticipant dataPerinatal outcomesPreterm birthSystematic reviewIndividual participant data analysisLow overall event rateComposite of stillbirthMain secondary outcomesUnpublished cohort studiesAdverse perinatal outcomesMore study participantsOverall event rateTwo-arm studyWeb of ScienceCohort studySecondary outcomesSingleton pregnanciesPrimary outcome
2020
Coronavirus disease 2019 pregnancy outcomes in a racially and ethnically diverse population
Grechukhina O, Greenberg V, Lundsberg LS, Deshmukh U, Cate J, Lipkind HS, Campbell KH, Pettker CM, Kohari KS, Reddy UM. Coronavirus disease 2019 pregnancy outcomes in a racially and ethnically diverse population. American Journal Of Obstetrics & Gynecology MFM 2020, 2: 100246. PMID: 33047100, PMCID: PMC7539936, DOI: 10.1016/j.ajogmf.2020.100246.Peer-Reviewed Original ResearchMeSH KeywordsAdultCommunicable Disease ControlComorbidityCOVID-19COVID-19 TestingEthnicityFemaleHealth Status DisparitiesHospitalizationHumansInfant, NewbornNew YorkObstetrics and Gynecology Department, HospitalPregnancyPregnancy Complications, InfectiousPregnancy OutcomePremature BirthRisk AssessmentRisk FactorsSARS-CoV-2ConceptsCoronavirus disease 2019Severe acute respiratory syndrome coronavirusAcute respiratory syndrome coronavirusSevere diseaseDisease 2019Pregnancy outcomesPositive test resultsClinical coursePostpartum womenRisk factorsHispanic ethnicityHispanic womenSevere acute respiratory syndrome coronavirus 2Coronavirus disease 2019 courseAcute respiratory syndrome coronavirus 2Severe coronavirus disease 2019Respiratory syndrome coronavirus 2Severe acute respiratory syndrome 2Effect of comorbidityWorse clinical courseC-reactive proteinSyndrome coronavirus 2Hypertensive disordersMedical comorbiditiesObese women
2019
Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses
Ovadia C, Seed PT, Sklavounos A, Geenes V, Di Illio C, Chambers J, Kohari K, Bacq Y, Bozkurt N, Brun-Furrer R, Bull L, Estiú MC, Grymowicz M, Gunaydin B, Hague WM, Haslinger C, Hu Y, Kawakita T, Kebapcilar AG, Kebapcilar L, Kondrackienė J, Koster MPH, Kowalska-Kańka A, Kupčinskas L, Lee RH, Locatelli A, Macias RIR, Marschall HU, Oudijk MA, Raz Y, Rimon E, Shan D, Shao Y, Tribe R, Tripodi V, Abide C, Yenidede I, Thornton JG, Chappell LC, Williamson C. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. The Lancet 2019, 393: 899-909. PMID: 30773280, PMCID: PMC6396441, DOI: 10.1016/s0140-6736(18)31877-4.Peer-Reviewed Original ResearchMeSH KeywordsAlanine TransaminaseAspartate AminotransferasesBile Acids and SaltsBilirubinBiomarkersCase-Control StudiesCholestasis, IntrahepaticCohort StudiesFemaleHumansInfant, NewbornPerinatal DeathPregnancyPregnancy ComplicationsPremature BirthRandomized Controlled Trials as TopicRisk FactorsROC CurveStillbirthConceptsSerum bile acid concentrationsBile acid concentrationsIndividual patient dataAdverse perinatal outcomesRisk of stillbirthPerinatal outcomesTotal bile acidsIntrahepatic cholestasisSingleton pregnanciesBile acidsBiochemical markersPregnancy casesHigh riskSerum total bile acidsTotal bile acid concentrationAdverse perinatal effectsPatient dataElevated bile acid concentrationsPopulation-based studyCase-control studyPrevalence of stillbirthUK National InstituteStepwise logistic regressionSpecific biochemical markersFull-text articles
2018
Cesarean Scar Pregnancy, Incidence, and Recurrence
Grechukhina O, Deshmukh U, Fan L, Kohari K, Abdel-Razeq S, Bahtiyar MO, Sfakianaki AK. Cesarean Scar Pregnancy, Incidence, and Recurrence. Obstetrics And Gynecology 2018, 132: 1285-1295. PMID: 30303911, DOI: 10.1097/aog.0000000000002940.Peer-Reviewed Original ResearchMeSH KeywordsAbortifacient Agents, NonsteroidalAdultCesarean SectionCicatrixCombined Modality TherapyCurettageFemaleHumansHysteroscopyMethotrexatePotassium ChloridePregnancyPregnancy RatePregnancy, EctopicRecurrenceTertiary Care CentersUterine Artery EmbolizationUterine Balloon TamponadeWatchful WaitingYoung AdultConceptsCesarean scar pregnancyScar pregnancySubsequent pregnancy outcomeLocal methotrexatePregnancy outcomesTreatment modalitiesRecurrent cesarean scar pregnancyBilateral uterine artery embolizationElectronic medical record reviewYale-New Haven HospitalSubsequent spontaneous conceptionViable intrauterine pregnancyPrior cesarean deliveryMedical record reviewTime of diagnosisUterine artery embolizationPotassium chloride injectionFetal cardiac activityProducts of conceptionIntrauterine pregnancyPregnancy characteristicsSystemic methotrexateExpectant managementMethotrexate therapyArtery embolization
2017
A Randomized Trial of Foley Balloon Induction of Labor Trial in Multiparas (FIAT-M)
Connolly KA, Kohari KS, Factor SH, Rekawek P, Miller MR, Smilen BS, Stone JL, Bianco AT. A Randomized Trial of Foley Balloon Induction of Labor Trial in Multiparas (FIAT-M). American Journal Of Perinatology 2017, 34: 1108-1114. PMID: 28651258, DOI: 10.1055/s-0037-1603994.Peer-Reviewed Original ResearchConceptsInduction of laborComposite neonatal outcomeNeonatal outcomesPostpartum hemorrhageFoley balloonMultiparous womenUnexplained vaginal bleedingLength of laborMode of deliveryHospital stayTreat basisUterine surgeryVaginal bleedingBaseline characteristicsLabor inductionSecondary outcomesBlood lossCesarean deliveryChart reviewLatex allergyPrimary outcomeVaginal deliveryMedian timeRandomized trialsVertex presentation
2016
Outcome after implementation of a modern management strategy for intrahepatic cholestasis of pregnancy
Kohari KS, Carroll R, Capogna S, Ditchik A, Fox NS, Ferrara LA. Outcome after implementation of a modern management strategy for intrahepatic cholestasis of pregnancy. The Journal Of Maternal-Fetal & Neonatal Medicine 2016, 30: 1342-1346. PMID: 27418248, DOI: 10.1080/14767058.2016.1212833.Peer-Reviewed Original ResearchConceptsNeonatal outcomesIntrahepatic cholestasisBile acidsContinuous fetal heart rate monitoringModern management strategiesGreater maternal ageRetrospective cohort studyFetal heart rate monitoringCesarean delivery rateTotal bile acidsNew management protocolNew cohortNICU admissionGestational diabetesSingleton gestationsCohort studyPatient demographicsPregnancy outcomesInpatient admissionsMaternal ageHeart rate monitoringStillbirth rateWeeksCholestasisOutcomesMitochondrial gene expression profiles are associated with intrahepatic cholestasis of pregnancy
Mella MT, Kohari K, Jones R, Peña J, Ferrara L, Stone J, Lambertini L. Mitochondrial gene expression profiles are associated with intrahepatic cholestasis of pregnancy. Placenta 2016, 45: 16-23. PMID: 27577705, DOI: 10.1016/j.placenta.2016.07.002.Peer-Reviewed Original ResearchConceptsOxidative stress statusIntrahepatic cholestasisHepatic bile acid accumulationHigher maternal serum levelsMaternal serum levelsSpontaneous preterm birthNon-pregnant stateBile acid levelsBile acid concentrationsBile acid accumulationStress statusPathophysiology of ICPOxidative stress ratePreterm birthClinical courseFetal demiseSerum levelsFetal effectsPregnant womenHigh oxidative stressReal-time PCRLong-term effectsMitochondrial activityPlacenta samplesBile acidsA randomized trial of Foley balloon induction of labor trial in nulliparas (FIAT-N)
Connolly KA, Kohari KS, Rekawek P, Smilen BS, Miller MR, Moshier E, Factor SH, Stone JL, Bianco AT. A randomized trial of Foley balloon induction of labor trial in nulliparas (FIAT-N). American Journal Of Obstetrics And Gynecology 2016, 215: 392.e1-392.e6. PMID: 27018464, DOI: 10.1016/j.ajog.2016.03.034.Peer-Reviewed Original ResearchConceptsComposite neonatal outcomeFoley balloonNeonatal outcomesNulliparous womenBlood lossVaginal deliveryPostpartum hemorrhageSequential groupUnexplained vaginal bleedingInduction of laborMode of deliveryUterine surgeryTreat basisUnfavorable cervixVaginal bleedingBaseline characteristicsCesarean deliveryChart reviewSecondary outcomesLatex allergyPrimary outcomeVertex presentationGestational ageSingle institutionSingleton fetuses
2015
Higher-order Multiples
Stone J, Kohari KS. Higher-order Multiples. Clinical Obstetrics & Gynecology 2015, 58: 668-675. PMID: 26165180, DOI: 10.1097/grf.0000000000000121.Peer-Reviewed Original Research
2012
Persistence of Placenta Previa in Twin Gestations Based on Gestational Age at Sonographic Detection
Kohari KS, Roman AS, Fox NS, Feinberg J, Saltzman DH, Klauser CK, Rebarber A. Persistence of Placenta Previa in Twin Gestations Based on Gestational Age at Sonographic Detection. Journal Of Ultrasound In Medicine 2012, 31: 985-989. PMID: 22733846, DOI: 10.7863/jum.2012.31.7.985.Peer-Reviewed Original ResearchConceptsPlacenta previaGestational ageTwin pregnanciesSonographic detectionTwin gestationsGestational age advancesSingle ultrasound unitType of previaLikelihood of resolutionComplete previaInternal osRetrospective cohortWeeks' gestationPlacental edgeSecond trimesterEarly gestationPreviaGestationPregnancyStudy outcomesTransvaginal imagingAge advancesAgeUltrasound unitWeeks